In:
Mini-Reviews in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 21, No. 18 ( 2021-11), p. 2630-2656
Abstract:
Aging is an unavoidable process, leading to cell senescence due to physiochemical changes
in an organism. Anti-aging remedies have always been of great interest since ancient times. The purpose of anti-aging activities is to increase the life span and the quality of life. Anti-aging activities are
primarily involved in the therapies of age-related disorders such as Parkinson's Disease (PD), Alzheimer's Disease (AD), cardiovascular diseases, cancer, and chronic obstructive pulmonary diseases. These
diseases are triggered by multiple factors that are involved in numerous molecular pathways including telomere shortening, NF- & #954;B pathway, adiponectin receptor pathway, insulin, and IGF signaling
pathway, AMPK, mTOR, and mitochondria dysfunction. Natural products are known as effective molecules to delay the aging process through influencing metabolic pathways and thus ensure an extended
lifespan. These natural compounds are being utilized in drug design and development through computational and high throughput techniques for effective pro-longevity drugs. A comprehensive study on
natural compounds demonstrating their anti-aging activities along with databases of natural products for drug designing was executed and summarized in this review article.
Type of Medium:
Online Resource
ISSN:
1389-5575
DOI:
10.2174/1389557521666210405162006
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
SSG:
15,3
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