In:
Arthritis & Rheumatism, Wiley, Vol. 34, No. 2 ( 1991-02), p. 224-227
Abstract:
We studied allotypes of the fourth component of complement (C4) and factor B in 76 patients with Sjögren's syndrome (SS) and in 63 normal subjects. C4A‐null (C4AQO) was found in 10 of 28 patients who had primary SS, compared with 1 of 63 control subjects ( P ⩽ 0.005). In contrast, no significant difference in the frequency of any C4 allotype was observed between patients with secondary SS and control subjects. An association of HLA–DRw53 with primary SS in Japanese patients has been reported. Since there is no linkage disequilibrium between DRw53 and C4AQO, it is possible that at least 2 genes in the major histocompatibility complex may determine susceptibility to the development of primary SS in the Japanese population.
Type of Medium:
Online Resource
ISSN:
0004-3591
,
1529-0131
DOI:
10.1002/art.1780340216
Language:
English
Publisher:
Wiley
Publication Date:
1991
detail.hit.zdb_id:
2014367-9
detail.hit.zdb_id:
127294-9
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