In:
FEBS Letters, Wiley, Vol. 582, No. 6 ( 2008-03-19), p. 925-930
Abstract:
We have investigated the radioprotective efficacy of eckol, a component of brown seaweed Ecklonia cava , against the gamma ray‐induced damage in vivo. Our results showed that eckol significantly decreased the mortality of lethally irradiated mice. The mechanisms of eckol's protection were found to include: an improvement in hematopoietic recovery, the repair of damaged DNA in immune cells and an enhancement of their proliferation, which had been severely suppressed by ionizing radiation. Thus, we propose eckol as a candidate for adjuvant therapy to alleviate radiation‐induced injuries to cancer patients.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/j.febslet.2008.02.031
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
1460391-3
SSG:
12
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