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  • 1
    In: Bangladesh Journal of Neuroscience, Bangladesh Academy of Sciences, Vol. 29, No. 1 ( 2013-01-31), p. 43-53
    Abstract: Background: Epidemiologic studies have reported that microalbuminuria is a risk factor for stroke in men and a limited case control study found that the highest quintile of microalbuminuria values was associated with 13 fold increased risk for stroke. The goal of this study was designed to determine its relationship to risk factors for ischemic stroke. Materials and Methods: It was a prospective observational study conducted in the Department of Neurology, Sir Salimullah Medical College & Mitford Hospital, Dhaka, Bangladesh. Fifty consecutive patients with ischemic stroke were enrolled in this study, with at least two risk factors that fulfilled the inclusion criteria and were confirmed by CT or MRI of brain. Equal number of controls of same age group without stroke who had at least two risk factors was compared with the case group. The patients were assessed clinically with structured questionnaire including blood pressure, height and weight, and monitoring blood glucose and microalbuminuria. Results: Microalbuminuria was found 58.0% in patients with ischemic stroke. Patients who had diabetes mellitus will have 13.86 times the risk for developing of microalbuminuria (p 〈 0.05). Patients who had hypertension will have 4.19 times the risk of developing microalbuminuria (p 〈 0.05) and BMI (e”23 kg/m2) will have 4.24 times the risk of developing microalbuminuria (p 〈 0.05). Whereas TIA, IHD, dyslipidemia, smoking and positive family history were not significantly (P 〉 0.05) associated with microalbuminuria in patients with ischemic stroke. Conclusion: The findings of this study show that diabetes is the factor most closely associated with microalbuminuria followed by HTN and BMI 〉 23 kg/ m2 with statistically significance in patients with ischemic stroke. Bangladesh Journal of Neuroscience 2013; Vol. 29 (1) : 43-53
    Type of Medium: Online Resource
    ISSN: 2408-8382 , 1023-4853
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2013
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  • 2
    In: Chattagram Maa-O-Shishu Hospital Medical College Journal, Bangladesh Academy of Sciences, Vol. 12, No. 3 ( 2013-10-28), p. 27-33
    Abstract: Background: Several epidemiological studies have identified the association of abnormal ABPI with ischemic stroke. So the goal of this study was to determine the actual relationship of ABPI with ischemic stroke in the context of our country. Methods: This case control study was carried out in the Department of Neurology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh. ABPI was measured by Doppler ultrasound machine of 100 patients who were admitted to the Mitford Hospital during the study period. Among them 50 patients with Ischemic stroke, confirmed by CT/MRI scan of brain were considered as case and 50 age-sex matched individuals with one or more vascular risk factors (VRF) but without stroke were considered as control. Then the results of ABPI were compared between the two groups. Results: Among the 50 patients with ischemic stroke (case group), 74% had normal ABPI and 26% had ABPI 〈 0.9; on the other hand among 50 age and sex matched individuals (control group) 90% had normal ABPI and 10% had ABPI 〈 0.9. The difference was statistically significant between two groups. (p= 〈 0.05).This association remained significant even after adjustment for potential confounders (age, gender, high BMI, hypertension, diabetes mellitus, hyperlipidemia, smoking, ischemic heart disease and family history) in a multiple logistic regression model. Conclusion: The incidence of low ABPI is significantly higher in ischemic stroke patients than the age- sex matched control. Chattagram Maa-O-Shishu Hospital Medical College Journal Volume 12, Issue 3, September 2013: 27-33
    Type of Medium: Online Resource
    ISSN: 2306-4919 , 2305-7890
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2013
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  • 3
    In: Bangladesh Journal of Neuroscience, Bangladesh Academy of Sciences, Vol. 29, No. 2 ( 2013-07-31), p. 79-87
    Abstract: Background: In the developing countries where TB is endemic; an ideal test for tuberculous meningitis should be economic, minimally invasive, of high accuracy and quick to perform.In many countries, also in India, several studies were conducted to establish the ADA activity as a sensitive and specific test of tuberculous meningitis.So it is very much needed to evaluate the diagnostic role of CSF ADA in tuberculous meningitis in Bangladesh. Aim: This study aimed to find out CSF ADA as a sensitive and specific test for early diagnosis of tuberculous meningitis. Methods: This case control study was carried out in the Department of Neurology, SSMC and Mitford Hospital, Dhaka from June 2011 to July 2012, to evaluate ADA activity in CSF for diagnosis of tuberculous meninigitis. Results: In the present study, sixty meningitis patients were enrolled. Of which, 30(50%) were tuberculous meningitis (TBM) taken as cases and rest 30(50%) were non-tuberculous meningitis (NTBM) taken as control.The CSF ADA activity from TBM patients was compared with CSF ADA from non-TBM infectious meningitis patients. The mean CSF ADA activity was found to be significantly higher in CSF of TBM patients, 14.01 ± 12.4 (1.0–65.2), mean ± SD with range, than in the CSF from non-TBM infectious meningitis, 7.2 ± 8.2 (1.8–49.1) P = 0.01.A cut-off value of 〉 7.6 U/L for the TBM patients was calculated from the mean ±SD of the non-TBM patients.The ADA sensitivity is 81.82%,specificity 65.31%,accuracy 68.33%, PPV 34.62%,NPV 94.12%, positive likelyhood ratio 2.3 and lastly negative likelyhood ratio 0.2 for infectious TBM when this cut-off value was used.ROC curve shows area under curve of .736 suggests a moderate accuracy of the test in detection of tuberculous meningitis. Conclusion: This study demonstrated that ADA activity in the CSF of TBM patients, using a cut off value 7.6 U/L, can be useful for the early differential diagnosis of TBM. This test can be performed in any pathology laboratory where more sophisticated methods are not available. Bangladesh Journal of Neuroscience 2013; Vol. 29 (2) : 79-87
    Type of Medium: Online Resource
    ISSN: 2408-8382 , 1023-4853
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2013
    detail.hit.zdb_id: 2573887-2
    Location Call Number Limitation Availability
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  • 4
    In: Bangladesh Journal of Neuroscience, Bangladesh Academy of Sciences, Vol. 29, No. 1 ( 2013-01-31), p. 31-42
    Abstract: Background: Several epidemiological studies have identified the association of abnormal ABPI with ischemic stroke. So the goal of this study was to determine the actual relationship of ABPI with ischemic stroke in the context of our country. Materials and Methods: This case control study was carried out in the Department of Neurology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh. ABPI was measured by Doppler ultrasound machine of 100 patients who were admitted to the Mitford Hospital during the study period. Among them 50 patients with Ischemic stroke, confirmed by CT/MRI scan of brain were considered as ‘case’ and 50 age- sex matched individuals with one or more vascular risk factors (VRF) but without stroke were considered as ‘control’. Then the results of ABPI were compared between the two groups. Results: Among the 50 patients with ischemic stroke (case group) , 74% had normal ABPI and 26% had ABPI 〈 0.9; on the other hand among 50 age and sex matched individuals (control group) 90% had normal ABPI and 10% had ABPI 〈 0.9. The difference was statistically significant between two groups (p= 〈 0.05).This association remained significant even after adjustment for potential confounders (age, gender, high BMI, hypertension, diabetes mellitus, hyperlipidemia, smoking, ischemic heart disease and family history) in a multiple logistic regression model. Conclusion: The incidence of low ABPI is significantly higher in ischemic stroke patients than the age- sex matched control. Bangladesh Journal of Neuroscience 2013; Vol. 29 (1) : 31-42
    Type of Medium: Online Resource
    ISSN: 2408-8382 , 1023-4853
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2013
    detail.hit.zdb_id: 2573887-2
    Location Call Number Limitation Availability
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  • 5
    Online Resource
    Online Resource
    Bangladesh Academy of Sciences ; 2013
    In:  Chattagram Maa-O-Shishu Hospital Medical College Journal Vol. 12, No. 3 ( 2013-10-28), p. 37-43
    In: Chattagram Maa-O-Shishu Hospital Medical College Journal, Bangladesh Academy of Sciences, Vol. 12, No. 3 ( 2013-10-28), p. 37-43
    Abstract: Background: Epidemiologic studies have reported that microalbuminuria is a risk factor for stroke in men and a limited case control study found that the highest quintile of microalbuminuria values was associated with 13 fold increased risk for stroke. The goal of this study is designed to determine its relationship to risk factors for ischemic stroke. Materials and Methods: It was a prospective observational study conducted in the Department of Neurology, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh. Fifty consecutive patients with ischemic stroke with at least two risk factors who fulfilled the inclusion criteria of case were confirmed by CT or MRI. Equal number of controls same ages without stroke who had at least two risk factors were compared with the case group. The patients were assessed clinically with structured questionnaire including blood pressure, height and weight, and monitoring blood glucose and microalbuminuria. Results: Microalbuminuria was found 58.0% in patients with ischemic stroke. Patients who had diabetes mellitus will have 13.86 times the risk for developing microalbuminuria (p 〈 0.05). Patients who had HTN will have 4.19 times the risk for developing microalbuminuria (p 〈 0.05) and BMI (?23 kg/m2) will have 4.24 times the risk for developing microalbuminuria with (p 〈 0.05). Whereas TIA, IHD, dyslipidemia, smoking and positive family history were not significantly (P 〉 0.05) associated with microalbuminuria in patients with ischemic stroke. Conclusion: The findings of this study show that diabetes is the factor most closely associated with microalbuminuria followed by HTN and BMI?23 kg/m2 with statistically significance in patients with ischemic stroke. Chattagram Maa-O-Shishu Hospital Medical College Journal Volume 12, Issue 3, September 2013: 37-43
    Type of Medium: Online Resource
    ISSN: 2306-4919 , 2305-7890
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2013
    Location Call Number Limitation Availability
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  • 6
    Online Resource
    Online Resource
    Bangladesh Academy of Sciences ; 2015
    In:  Bangladesh Journal of Neuroscience Vol. 31, No. 1 ( 2015-01-31), p. 9-14
    In: Bangladesh Journal of Neuroscience, Bangladesh Academy of Sciences, Vol. 31, No. 1 ( 2015-01-31), p. 9-14
    Abstract: Aim: Recent studies have provided evidence that uric acid (UA) is supposed to play a neuro-protective role in Parkinson’s disease (PD). Uric acid is a natural antioxidant that may reduce oxidative stress, a mechanism thought to play a role in the pathogenesis of PD. This study aimed to evaluate whether the serum UA level was associated with PD in a relatively small population of Bangladeshi patients. Materials and methods: An observational prospective case control Study was conducted in Neurology department of Sir Salimullah Medical College & Mitford Hospital including both the male and female wards during July 2012 to December 2013. Serum uric acid were determined from 40 PD patients and compared with 70 age and sex matched control; following the uric acid colorimetric method, the serum creatinine (Scr) levels were also measured to reduce the bias caused by possible differences in renal excretion function. Data were analyzed with software SPSS 16 and statistical descriptive methods (mean percentage, SD) and t-test. Result: In this study, 22 men (55%) and 18 women (45%) with PD were evaluated. The mean serum uric acid in patients was 3.7±0.97 and in the control group was 5.32 ±0.44. This difference was statistically significant.(p=0.001) Also, the mean serum uric acid in both men (3.48±0.98) and women (4.1±1.17) patients group was statistically lower than both men (5.39±0.46) and women (5.17±0.35) in control group.(p=0.001). Conclusion: This present study showed a positive association between low serum UA and PD . Bangladesh Journal of Neuroscience 2015; Vol. 31 (1): 9-14
    Type of Medium: Online Resource
    ISSN: 2408-8382 , 1023-4853
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2015
    detail.hit.zdb_id: 2573887-2
    Location Call Number Limitation Availability
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  • 7
    Online Resource
    Online Resource
    Bangladesh Academy of Sciences ; 2016
    In:  Bangladesh Journal of Neuroscience Vol. 32, No. 2 ( 2016-07-31), p. 68-73
    In: Bangladesh Journal of Neuroscience, Bangladesh Academy of Sciences, Vol. 32, No. 2 ( 2016-07-31), p. 68-73
    Abstract: Background: Recent studies have provided evidence that uric acid (UA) is suspected to play a neuro-protective role in Parkinson’s disease (PD). Uric acid is a natural antioxidant that may reduce oxidative stress, a mechanism thought to play a role in the pathogenesis of PD. This study aimed to evaluate whether the serum UA level was associated with PD in a relatively small population of Bangladeshi patients. Materials and methods: An observational prospective case control Study was conducted in Neurology of Sir Salimullah Medical College & Mitford Hospital including both the male and female wards during July 2012 to December 2013. Serum uric acid were determined from 40 PD patients and compared with 70 age and sex matched control; following the uric acid colorimetric method, the serum creatinine (Scr) levels were also measured to reduce the bias caused by possible differences in renal excretion function. Data were analyzed with software SPSS 16 and statistical descriptive methods (mean percentage, SD) and t-test. Result: In this study, 22 men (55%) and 18 women (45%) with PD were evaluated. The mean serum uric acid in patients was 3.7±0.97 and in the control group was 5.32±0.44. This difference was statistically significant (p=0.001). Also, the mean serum uric acid in both men (3.48±0.98) and women (4.1±1.17) in patients group was statistically lower than both men (5.39±0.46) and women (5.17±0.35) in control group.(p=0.001). Conclusion: This present study showed a positive association between low serum UA and PD Bangladesh Journal of Neuroscience 2016; Vol. 32 (2): 68-73
    Type of Medium: Online Resource
    ISSN: 2408-8382 , 1023-4853
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2016
    detail.hit.zdb_id: 2573887-2
    Location Call Number Limitation Availability
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