In:
Cancer, Wiley, Vol. 126, No. 5 ( 2020-03), p. 1016-1030
Abstract:
PLEKHA5 , a gene involved in brain development, has previously been found to be aberrantly expressed in melanomas with a high propensity for brain metastasis. Here PLEKHA5 is shown to stimulate proliferation and tumor growth, possibly through the regulation of a cell cycle inhibitor, PDCD4, via crosstalk with PI3K/AKT/mTOR signaling pathways, a novel regulatory mechanism that could be exploited to develop new therapeutic strategies for this disease.
Type of Medium:
Online Resource
ISSN:
0008-543X
,
1097-0142
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1479932-7
detail.hit.zdb_id:
2599218-1
detail.hit.zdb_id:
2594979-2
detail.hit.zdb_id:
1429-1
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