In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 17, No. 10 ( 2023-10-10), p. e0011615-
Abstract:
Bartonella bacilliformis is a Gram-negative, aerobic bacterium and the known causal agent of Carrion’s disease, still considered a neglected disease. There is limited information about the nucleotide sequences of this bacterium in international databases, and few studies have addressed the genetic diversity of B . bacilliformis . We analyzed a total of 20 isolates of B . bacilliformis from the Peruvian regions of Ancash and Cajamarca. Three genes ( ialB , gltA , and rpoB ) were sequenced in each isolate and nucleotide sequences retrieved from GenBank (16 B . bacilliformis genomes) were also included in the study. All this information was merged in order to obtain clearer evidence of the phylogenetic relationships of B . bacilliformis . In the phylogenetic analysis conducted with the concatenated markers, four isolates (B.b-1, B. b-3, B. b- 7, B.b-8) from the Ancash region were observed to form a subgroup different from B . bacilliformis type strain KC583, showing dissimilarity levels of 5.96% ( ialB ), 3.69% ( gltA ) and 3.04% ( rpoB ). Our results suggest that B . bacilliformis consists of two different subgroups. Future investigations are needed to establish the taxonomic status of these subgroups.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0011615
DOI:
10.1371/journal.pntd.0011615.g001
DOI:
10.1371/journal.pntd.0011615.g002
DOI:
10.1371/journal.pntd.0011615.t001
DOI:
10.1371/journal.pntd.0011615.t002
DOI:
10.1371/journal.pntd.0011615.t003
DOI:
10.1371/journal.pntd.0011615.t004
DOI:
10.1371/journal.pntd.0011615.t005
DOI:
10.1371/journal.pntd.0011615.s001
DOI:
10.1371/journal.pntd.0011615.s002
DOI:
10.1371/journal.pntd.0011615.s003
DOI:
10.1371/journal.pntd.0011615.s004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2429704-5
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