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  • 1
    Online Resource
    Online Resource
    Dosimetric comparison study of intensity modulated radiotherapy technique (IMRT/VMAT) with three dimensional field-in-field tangents for left breast cancer irradiation
    Universidad Tecnica de Manabi ; 2022
    In:  International journal of health sciences ( 2022-11-02), p. 5739-5753
    Details
    In: International journal of health sciences, Universidad Tecnica de Manabi, ( 2022-11-02), p. 5739-5753
    Abstract: Purpose: To retrospectively compare dosimetrically three dimensional field-in-field tangents (3D F-in-F), Intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) left breast irradiation plans. Materials and Methods: A total of 30 patients were included in this study. All patients diagnosed with early–stage malignant neoplasm of the breast prior to treatment. Patients were contoured with three main PTV-Chest wall (PTVCW), PTV-Axilla (PTVAX), and PTV-IMC (PTVIMC). Monaco treatment planning system was used to create the plans. For each patient, three treatment plans were created; three dimensional conformal radiotherapy (3D-CRT), intensity modulated radiotherapy (IMRT), and volumetric modulated arc therapy (VMAT). The dose coverage of PTVs and the dose constraints of Organ-at-Risks (OARs) were compared and analyzed. Results: The dose objective to cover the PTVs; PTVCW, PTVAX, and PTVIMC were V40.43Gy (95%) ≥ 95%, V38.3Gy (90%) ≥ 95%, and V34.05Gy (80%) ≥ 95% respectively. Comparing the dose coverage of PTVCW between 3D-CRT and VMAT, resulted in a significant difference (P= 0.003) and the VMAT was superior for the coverage of target than 3D-CRT. For PTVAX, the coverage was 45.80±0.55, 45.96±0.73, and 45.58±0.63 for 3D-CRT, IMRT, and VMAT respectively. For PTVIMC, the coverage was 45.80±0.55, 45.96±0.73, and 45.58±0.63 for 3D-CRT, IMRT, and VMAT respectively. 
    Type of Medium: Online Resource
    ISSN: 2550-696X , 2550-6978
    URL: Issue
    URL: Article
    DOI: 10.53730/ijhs.v6nS8.2022
    DOI: 10.53730/ijhs.v6nS8.13584
    Language: Unknown
    Publisher: Universidad Tecnica de Manabi
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    Improving Physicians' Adherence to Guidelines Regarding Antibiotics Use in Acute Upper Respiratory Tract Infections in Adult Patients Attending Ministry of Health Hospitals in Alexandria, Egypt: An Interventional Study
    OMICS Publishing Group ; 2018
    In:  Journal of Microbial & Biochemical Technology Vol. 10, No. 1 ( 2018)
    Details
    In: Journal of Microbial & Biochemical Technology, OMICS Publishing Group, Vol. 10, No. 1 ( 2018)
    Type of Medium: Online Resource
    ISSN: 1948-5948
    URL: Journal
    URL: Article
    DOI: 10.4172/1948-5948
    DOI: 10.4172/1948-5948.1000389
    Language: Unknown
    Publisher: OMICS Publishing Group
    Publication Date: 2018
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  • 3
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    Online Resource
    The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites
    Wiley ; 2015
    In:  MicrobiologyOpen Vol. 4, No. 1 ( 2015-02), p. 66-83
    Details
    In: MicrobiologyOpen, Wiley, Vol. 4, No. 1 ( 2015-02), p. 66-83
    Abstract: N ε ‐lysine acetylation is an abundant posttranslational modification of thousands of proteins involved in diverse cellular processes. In the model bacterium Escherichia coli , the ε ‐amino group of a lysine residue can be acetylated either catalytically by acetyl‐coenzyme A (acCoA) and lysine acetyltransferases, or nonenzymatically by acetyl phosphate (acP). It is well known that catalytic acCoA‐dependent N ε ‐lysine acetylation can be reversed by deacetylases. Here, we provide genetic, mass spectrometric, structural and immunological evidence that CobB, a deacetylase of the sirtuin family of NAD + ‐dependent deacetylases, can reverse acetylation regardless of acetyl donor or acetylation mechanism. We analyzed 69 lysines on 51 proteins that we had previously detected as robustly, reproducibly, and significantly more acetylated in a cobB mutant than in its wild‐type parent. Functional and pathway enrichment analyses supported the hypothesis that CobB regulates protein function in diverse and often essential cellular processes, most notably translation. Combined mass spectrometry, bioinformatics, and protein structural data provided evidence that the accessibility and three‐dimensional microenvironment of the target acetyllysine help determine CobB specificity. Finally, we provide evidence that CobB is the predominate deacetylase in E. coli .
    Type of Medium: Online Resource
    ISSN: 2045-8827 , 2045-8827
    URL: Issue
    URL: Article
    DOI: 10.1002/mbo3.2015.4.issue-1
    DOI: 10.1002/mbo3.223
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2661368-2
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  • 4
    Online Resource
    Online Resource
    The degree of virulence does not necessarily affect MRSA biofilm strength and response to photodynamic therapy
    Elsevier BV ; 2016
    In:  Microbial Pathogenesis Vol. 91 ( 2016-02), p. 54-60
    Details
    In: Microbial Pathogenesis, Elsevier BV, Vol. 91 ( 2016-02), p. 54-60
    Type of Medium: Online Resource
    ISSN: 0882-4010
    URL: Article
    DOI: 10.1016/j.micpath.2015.11.012
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 1471158-8
    SSG: 12
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  • 5
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    Table_3.XLSX
    Frontiers Media SA ; 2022
    In:  Frontiers in Veterinary Science Vol. 9 ( 2022-12-13)
    Details
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 9 ( 2022-12-13)
    Abstract: Staphylococci other than Staphylococcus aureus (SOSA) in animals are becoming more pathogenic and antibiotic resistant and can potentially disseminate to humans. However, there is little synthesized information regarding SOSA from animals in Africa. This systematic review provides a comprehensive overview of the epidemiology and antimicrobial resistance of SOSA in companion animals (pets) and livestock in Africa. Method This systematic review (PROSPERO-CRD42021252303) was conducted according to the PRISMA guidelines, and 75 eligible studies from 13 countries were identified until August 2022. Three electronic databases (Pubmed, Scopus and Web of Science) were employed. Results The frequently isolated SOSA were S. epidermidis, S. intermedius, S. pseudintermedius, S. xylosus, S. chromogenes, S. hyicus, M. sciuri, S. hominis , and S. haemolyticus . Thirty (40%) studies performed antibiotic susceptibility testing (AST). Penicillin (58%) and tetracycline (28%) resistance were most common across all SOSA with high rates of resistance to aminoglycosides, fluoroquinolones, and macrolides in some species. Resistance to last-resort antibiotics such as linezolid and fusidic acid were also reported. Limited data on strain typing and molecular resistance mechanisms precluded analysis of the clonal diversity of SOSA on the continent. Conclusion The findings of this review indicate that research on livestock-associated SOSA in Africa is lacking in some regions such as Central and Western Africa, furthermore, research on companion animals and more advanced methods for identification and strain typing of SOSA need to be encouraged. Systematic review registration https://www.crd.york.ac.uk/prospero/ , identifier: CRD42021252303.
    Type of Medium: Online Resource
    ISSN: 2297-1769
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fvets.2022.1059054
    DOI: 10.3389/fvets.2022.1059054.s001
    DOI: 10.3389/fvets.2022.1059054.s002
    DOI: 10.3389/fvets.2022.1059054.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2834243-4
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  • 6
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    Team science: the power of Us
    Moroccan Association for Research and Ethics ; 2022
    In:  (IJRE) International Journal of Research and Ethics (ISSN 2665-7481) Vol. 5, No. 1 ( 2022-02-01)
    Details
    In: (IJRE) International Journal of Research and Ethics (ISSN 2665-7481), Moroccan Association for Research and Ethics, Vol. 5, No. 1 ( 2022-02-01)
    Abstract: In a world described as a global village where borders matter very little, many researchers seek scientific collaboration for different reasons, such as securing more funding, expertise and/or specialized equipment, new ideas, etc. Scientific collaboration (also known as team science) has many forms and can occur between researchers not necessarily at the same stage in their career. Collaboration can be internal within the same establishment or external, national or international,interdisciplinary or uni-disciplinary, of equal or different shares, each with its own sets of advantages and threats. However, when managed properly, team science increases opportunities and maximizes research impact. Yet, it comes with some challenges, including culture and language barriers, availability of funds to implement the collaboration, researchers’ grasp of the collaboration dynamics, etc. Finding the right collaborators with mutual or complementing interests is key for the success of the collaboration. So are good communication skills, trust and a clear understanding by all parties of the terms of the collaboration to minimize conflict. A successful collaboration is synergistic while being respectful of and building on each member’s potential. It is also a dynamic relationship with positive results that can reach far into the future beyond the actual duration of the collaboration.Keywords: scientific collaboration, Research impact, cultural and language barriers, Funding,Communication, Standards.
    Type of Medium: Online Resource
    ISSN: 2665-7481
    URL: Issue
    URL: Article
    DOI: 10.51766/ijre.v5i1
    DOI: 10.51766/ijre.v5i1.114
    Language: Unknown
    Publisher: Moroccan Association for Research and Ethics
    Publication Date: 2022
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  • 7
    Online Resource
    Online Resource
    Knowledge, Attitude, and Practice of Middle East and North African Populations toward COVID -19
    Moroccan Association for Research and Ethics ; 2022
    In:  (IJRE) International Journal of Research and Ethics (ISSN 2665-7481) Vol. 5, No. 2 ( 2022-02-13)
    Details
    In: (IJRE) International Journal of Research and Ethics (ISSN 2665-7481), Moroccan Association for Research and Ethics, Vol. 5, No. 2 ( 2022-02-13)
    Abstract: Objective: This study aimed to assess the basic knowledge, attitude, and practice among people from nine Middle Eastern and North African countries about COVID-19 symptoms, modes of transmission, acceptance of recovered patients, and practice of some basic preventive measures. Methods: In this cross-sectional study, data was collected from 3515 participants in nine Middle Eastern and North African countries using an online self-administered questionnaire to assess participants' basic knowledge, attitude, and practice of some preventive measures related to COVID-19. Results: In this study, most of the participants were aware of the basic preventive measures against coronavirus. Despite this awareness, the practice of these measures was low, with a significant variation among participating countries and gender. Social media was the major source of their information. More than half of participants (53.2%) would not accept recovered patients in the community without protective measures, and the majority (84%) of them believed that people living in hot and sunny areas are less susceptible and affected by COVID-19. Conclusion: Our findings indicate that participants of Middle Eastern and North African countries have relatively good knowledge and attitudes regarding COVID-19. Still, they have unsatisfactory preventive practices, and more than half of them refuse to accept recovered patients as normal in the community without protective measures.
    Type of Medium: Online Resource
    ISSN: 2665-7481
    URL: Issue
    URL: Article
    DOI: 10.51766/ijre.v5i2
    DOI: 10.51766/ijre.v5i2.86
    Language: Unknown
    Publisher: Moroccan Association for Research and Ethics
    Publication Date: 2022
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  • 8
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    Online Resource
    Role of plasmid carrying blaNDM in mediating antibiotic resistance among Acinetobacter baumannii clinical isolates from Egypt
    Springer Science and Business Media LLC ; 2020
    In:  3 Biotech Vol. 10, No. 4 ( 2020-04)
    Details
    In: 3 Biotech, Springer Science and Business Media LLC, Vol. 10, No. 4 ( 2020-04)
    Type of Medium: Online Resource
    ISSN: 2190-572X , 2190-5738
    URL: Article
    DOI: 10.1007/s13205-020-2157-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2600522-0
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  • 9
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    Table_1.XLSX
    Frontiers Media SA ; 2021
    In:  Frontiers in Microbiology Vol. 12 ( 2021-6-4)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 12 ( 2021-6-4)
    Abstract: Staphylococci can cause a wide array of infections that can be life threatening. These infections become more deadly when the isolates are antibiotic resistant and thus harder to treat. Many resistance determinants are plasmid-mediated; however, staphylococcal plasmids have not yet been fully characterized. In particular, plasmids and their contributions to antibiotic resistance have not been investigated within the Arab states, where antibiotic use is not universally regulated. Here, we characterized the putative plasmid content among 56 Staphylococcus aureus and 10 Staphylococcus haemolyticus clinical isolates from Alexandria, Egypt. Putative plasmid sequences were detected in over half of our collection. In total, we identified 72 putative plasmid sequences in 27 S. aureus and 1 S. haemolyticus isolates. While these isolates typically carried one or two plasmids, we identified one isolate— S. aureus AA53—with 11 putative plasmids. The plasmid sequences most frequently encoded a Rep_1, RepL, or PriCT_1 type replication protein. As expected, antibiotic resistance genes were widespread among the identified plasmid sequences. Related plasmids were identified amongst our clinical isolates; homologous plasmids present in multiple isolates clustered into 11 groups based upon sequence similarity. Plasmids from the same cluster often shared antibiotic resistance genes, including blaZ , which is associated with β-lactam resistance. Our analyses suggest that plasmids are a key factor in the pathology and epidemiology of S. aureus in Egypt. A better characterization of plasmids and the role they contribute to the success of Staphylococci as pathogens will guide the design of effective control strategies to limit their spread.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    URL: Article
    DOI: 10.3389/fmicb.2021.659116
    DOI: 10.3389/fmicb.2021.659116.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587354-4
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  • 10
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    Online Resource
    Whole-Genome Sequencing of Staphylococcus aureus and Staphylococcus haemolyticus Clinical Isolates from Egypt
    American Society for Microbiology ; 2022
    In:  Microbiology Spectrum Vol. 10, No. 4 ( 2022-08-31)
    Details
    In: Microbiology Spectrum, American Society for Microbiology, Vol. 10, No. 4 ( 2022-08-31)
    Abstract: Infections caused by antibiotic-resistant Staphylococcus are a global concern. This is true in the Middle East, where increasingly resistant Staphylococcus aureus and Staphylococcus haemolyticus strains have been detected. While extensive surveys have revealed the prevalence of infections caused by antibiotic-resistant staphylococci in Europe, Asia, and North America, the population structure of antibiotic-resistant staphylococci recovered from patients and clinical settings in Egypt remains uncharacterized. We performed whole-genome sequencing of 56 S. aureus and 10 S. haemolyticus isolates from Alexandria Main University Hospital; 46 of the S. aureus genomes and all 10 of the S. haemolyticus genomes carry mecA , which confers methicillin resistance. Supplemented with additional publicly available genomes from the other parts of the Middle East (34 S. aureus and 6 S. haemolyticus ), we present the largest genomic study to date of staphylococcal isolates from the Middle East. These genomes include 20 S. aureus multilocus sequence types (MLST), including 3 new ones. They also include 9 S. haemolyticus MLSTs, including 1 new one. Phylogenomic analyses of each species’ core genome largely mirrored those of the MLSTs, irrespective of geographical origin. The hospital-acquired spa t037/ST239-SCC mec III/MLST CC8 clone represented the largest clade, comprising 22% of the S. aureus isolates. Like S. aureus genome surveys of other regions, these isolates from the Middle East have an open pangenome, a strong indicator of gene exchange of virulence factors and antibiotic resistance genes with other reservoirs. Our genome analyses will inform antibiotic stewardship and infection control plans in the Middle East. IMPORTANCE Staphylococci are understudied despite their prevalence within the Middle East. Methicillin-resistant Staphylococcus aureus (MRSA) is endemic to hospitals in Egypt, as are other antibiotic-resistant strains of S. aureus and S. haemolyticus . To provide insight into the strains circulating in Egypt, we performed whole-genome sequencing of 56 S. aureus and 10 S. haemolyticus isolates from Alexandria Main University Hospital. Through analysis of these genomes, as well as all available S. aureus and S. haemolyticus genomes from the Middle East ( n  = 40), we were able to produce a picture of the diversity in this region more complete than those afforded by traditional molecular typing strategies. For example, we identified 4 new MLSTs. Most strains harbored genes associated with multidrug resistance, toxin production, biofilm formation, and immune evasion. These data provide invaluable insight for future antibiotic stewardship and infection control within the Middle East.
    Type of Medium: Online Resource
    ISSN: 2165-0497
    URL: Article
    DOI: 10.1128/spectrum.02413-21
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2022
    detail.hit.zdb_id: 2807133-5
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