In:
Digestion, S. Karger AG, Vol. 97, No. 4 ( 2018), p. 288-297
Abstract:
〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 The rate of gastric cancer (GC) after 〈 i 〉 Helicobacter pylori 〈 /i 〉 eradication has gradually increased; therefore, we investigate the clinicopathological features of GC following eradication in comparison with those of GC with 〈 i 〉 H. pylori 〈 /i 〉 infection. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This study included 50 subjects with GC after eradication (GCE) and 151 patients with GC with 〈 i 〉 H. pylori 〈 /i 〉 infection (GCI). Clinicopathological factors were assessed. The manifestation of GC was further evaluated using immunohistochemical analysis and in situ hybridization. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Macroscopic analysis revealed a significantly higher ratio of depressed type /elevated type in the GCE compared with the GCI (30/19 vs. 61/77, 〈 i 〉 p 〈 /i 〉 = 0.041). The gastric phenotype was more common in the GCE compared with the GCI, and the proportion of CDX2-positive cases was lower in the GCE (8 out of 18; 44.4%) compared with the GCI (18 out of 19; 94.7%; 〈 i 〉 p 〈 /i 〉 = 0.00082). Ki-67 labeling index was significantly lower in the GCE (32.03 ± 22.15) compared with the GCI (79.20 ± 14.87, 〈 i 〉 p & #x3c; 〈 /i 〉 0.0001). No patient in the GCE showed evidence of Epstein-Barr virus infection. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The clinicopathological characteristics of GC following 〈 i 〉 H. pylori 〈 /i 〉 eradication differ from those of GC in patients with 〈 i 〉 H. pylori 〈 /i 〉 infection in terms of morphology, mucin phenotype, and proliferation rate.
Type of Medium:
Online Resource
ISSN:
0012-2823
,
1421-9867
Language:
English
Publisher:
S. Karger AG
Publication Date:
2018
detail.hit.zdb_id:
1482218-0
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