In:
Cardiology, S. Karger AG, Vol. 89, No. 2 ( 1998), p. 94-102
Abstract:
In 753 patients with acute myocardial infarction, use of fish oils (FO, n = 242) before onset of infarction seemed to reduce infarct size as estimated from peak creatine kinase (CK 〈 sub 〉 max 〈 /sub 〉 ) and lactate dehydrogenase (LD 〈 sub 〉 max 〈 /sub 〉 ) activities. The study had an observational exposed/nonexposed design, and both crude and adjusted effects were looked for. 〈 b 〉 Crude Effects: 〈 /b 〉 In the restricted cohort of patients not receiving thrombolytic treatment (n = 411), FO reduced CK 〈 sub 〉 max 〈 /sub 〉 from 879 to 759 U/l (2 p = 0.030) and LD 〈 sub 〉 max 〈 /sub 〉 from 870 to 768 U/l (2 p = 0.011), respectively. More of these patients in the lowest enzyme quartiles used FO, p for linear trend was for CK 〈 sub 〉 max 〈 /sub 〉 0.008 and for LD 〈 sub 〉 max 〈 /sub 〉 0.06, respectively. 〈 b 〉 Adjusted Effects: 〈 /b 〉 In patients not receiving thrombolytic treatment, FO reduced CK 〈 sub 〉 max 〈 /sub 〉 (2 p = 0.007) and LD 〈 sub 〉 max 〈 /sub 〉 (2 p = 0.005), but in patients receiving such treatment, CK 〈 sub 〉 max 〈 /sub 〉 and LD 〈 sub 〉 max 〈 /sub 〉 values increased, 2 p being 0.036 and 0.097, respectively. In patients not receiving thrombolysis, FO increased the incidence of small infarcts (the 25% quartile), odds ratio for CK 〈 sub 〉 max 〈 /sub 〉 was 1.82 (2 p = 0.018) and for LD 〈 sub 〉 max 〈 /sub 〉 1.66 (2 p = 0.048), respectively. The results indicate that FO may reduce infarct size and the incidence of large infarcts. In addition, FO seems to enhance the effect of thrombolysis.
Type of Medium:
Online Resource
ISSN:
0008-6312
,
1421-9751
Language:
English
Publisher:
S. Karger AG
Publication Date:
1998
detail.hit.zdb_id:
1482041-9
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