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  • 1
    Online Resource
    Online Resource
    Informa UK Limited ; 2011
    In:  Construction Management and Economics Vol. 29, No. 7 ( 2011-07), p. 659-670
    In: Construction Management and Economics, Informa UK Limited, Vol. 29, No. 7 ( 2011-07), p. 659-670
    Type of Medium: Online Resource
    ISSN: 0144-6193 , 1466-433X
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2011
    detail.hit.zdb_id: 1502289-4
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  • 2
    In: Pediatric Research, Springer Science and Business Media LLC, Vol. 93, No. 5 ( 2023-04), p. 1383-1390
    Abstract: Given the sparse data on vitamin D status in pediatric COVID-19, we investigated whether vitamin D deficiency could be a risk factor for susceptibility to COVID-19 in Egyptian children and adolescents. We also investigated whether vitamin D receptor (VDR) FokI polymorphism could be a genetic marker for COVID-19 susceptibility. Methods One hundred and eighty patients diagnosed to have COVID‐19 and 200 matched control children and adolescents were recruited. Patients were laboratory confirmed as SARS-CoV-2 positive by real-time RT-PCR. All participants were genotyped for VDR Fok1 polymorphism by RT-PCR. Vitamin D status was defined as sufficient for serum 25(OH) D at least 30 ng/mL, insufficient at 21–29 ng/mL, deficient at 〈 20 ng/mL. Results Ninety-four patients (52%) had low vitamin D levels with 74 (41%) being deficient and 20 (11%) had vitamin D insufficiency. Vitamin D deficiency was associated with 2.6-fold increased risk for COVID-19 (OR = 2.6; [95% CI 1.96–4.9]; P  = 0.002. The FokI FF genotype was significantly more represented in patients compared to control group (OR = 4.05; [95% CI: 1.95–8.55]; P   〈  0.001). Conclusions Vitamin D deficiency and VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents. Impact Vitamin D deficiency could be a modifiable risk factor for COVID-19 in children and adolescents because of its immune-modulatory action. To our knowledge, ours is the first such study to investigate the VDR Fok I polymorphism in Caucasian children and adolescents with COVID-19. Vitamin D deficiency and the VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents. Clinical trials should be urgently conducted to test for causality and to evaluate the efficacy of vitamin D supplementation for prophylaxis and treatment of COVID-19 taking into account the VDR polymorphisms.
    Type of Medium: Online Resource
    ISSN: 0031-3998 , 1530-0447
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2031217-9
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Trans Tech Publications, Ltd. ; 2011
    In:  Advanced Materials Research Vol. 214 ( 2011-2), p. 637-640
    In: Advanced Materials Research, Trans Tech Publications, Ltd., Vol. 214 ( 2011-2), p. 637-640
    Abstract: Research over the last decade has shown that composite floor structures can have a significantly greater fire resistance than is suggested by conventional tests on isolated elements, this is largely due to the interaction between the beams and floor slabs and beams-column connections in the fire compartment and the restraint afforded by the surrounding structure. This research was carried out to investigate the effect of fire on the behavior of reinforced concrete frames especially the connection between beam and column, where a special model for a fire furnace was designed in HBRC in order to investigate the aim of the current research. An experimental program consisted of thirteen statically independent two hinged reinforced concrete frames is designed to study the deformational behavior of RC frames subjected to fire under short term loading in terms of deflection and strain distribution, temperatures distribution along the critical cross sections at different limit states with the following variables: fire durations (1,2 and 3 hours), and fire temperatures (300,600 and 800°C) with concrete strength (250 and 600 kg/cm2). Modes of failure, ultimate capacity, deflection and strain of steel reinforcement and concrete at critical sections were examined experimentally and theoretically. The non-linear finite element analysis for reinforced concrete structure is largely dependant on the stress-strain relationships, failure criteria used, simulation of steel reinforcement and interaction between steel and concrete [1]. A model for predicting the behavior of reinforced concrete frames failure was developed based on experimental results obtained from the experimental program carried out by the authors. This model has been incorporated into a new reinforced concrete element for the non-linear analysis program, using ANSYS Ver.10 program. In this paper, a general description of the finite element method, theoretical modeling of concrete and reinforcement are presented. In order to verify the analytical model used in this research using test results of the experimental data of the experimental branch, the finite element analysis were performed then to be able to proposed a guide charts which can be used to predict the moment capacity of joint in beam-column connection in RC frames subjected to fire taking into consideration the different fire durations, fire temperature, and concrete strength.
    Type of Medium: Online Resource
    ISSN: 1662-8985
    URL: Issue
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2011
    detail.hit.zdb_id: 2265002-7
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