In:
Journal of the chemical society of pakistan, Chemical Society of Pakistan, Vol. 41, No. 3 ( 2019), p. 469-469
Abstract:
To deliver maximum amount of paroxetine in shortest duration of time, the orodispersible films (ODF) were formulated and tested for their suitability as a carrier system. ODF were prepared by using hydroxypropyl methylcellulose and polyvinyl alcohol and different superdisintegrants at a specific proportion. The newly developed ODF were subjected to characterization for folding endurance, weight variations, thickness, disintegration time, drug release pattern and drug content. The surface morphology of orodispersible film was examined by means of scanning electron microscope. Moreover physical compatibility between the drug and excipients was guaranteed in the orodispersible film by Fourier transform infrared spectroscopy. It was found that all films prepared were transparent, smooth and elegant in appearance. ODF showed good folding endurance, uniform thickness, weight and drug content. The surface pH of all orodispersible film was found to be neutral and they disintegrate within few seconds. FTIR spectroscopy supported compatible among all excipients and they can be used together in formulation. It was concluded that stable paroxetine orodispersible films can be made by solvent casting technique with ultrafast dissolution rate.
Type of Medium:
Online Resource
ISSN:
0253-5106
Uniform Title:
Orodispersible Films of an Antipsychotic Drug: Development and Physicochemical Characterization
DOI:
10.52568/000750/JCSP/41.03.2019
Language:
Unknown
Publisher:
Chemical Society of Pakistan
Publication Date:
2019
detail.hit.zdb_id:
3024078-5
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