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  • 1
    Online Resource
    Online Resource
    American Veterinary Medical Association (AVMA) ; 2016
    In:  Journal of the American Veterinary Medical Association Vol. 248, No. 11 ( 2016-06-01), p. 1235-1237
    In: Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), Vol. 248, No. 11 ( 2016-06-01), p. 1235-1237
    Type of Medium: Online Resource
    ISSN: 0003-1488
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2016
    detail.hit.zdb_id: 2904887-4
    SSG: 22
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  • 2
    Online Resource
    Online Resource
    American Veterinary Medical Association (AVMA) ; 2018
    In:  Journal of the American Veterinary Medical Association Vol. 253, No. 10 ( 2018-11-15), p. 1247-1249
    In: Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), Vol. 253, No. 10 ( 2018-11-15), p. 1247-1249
    Type of Medium: Online Resource
    ISSN: 0003-1488
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2018
    detail.hit.zdb_id: 2904887-4
    SSG: 22
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  • 3
    In: Veterinary Radiology & Ultrasound, Wiley, Vol. 58, No. 1 ( 2017-01), p. 23-28
    Abstract: Computed tomography (CT) continues to become more widely available for assessment of tumors in dogs, yet there are no studies describing the CT appearance of canine liposarcomas. In this retrospective, multicenter study, CT images of dogs with histologically confirmed liposarcomas were reviewed for size, location, attenuation, contrast enhancement, border definition, internal homogeneity, local infiltration, and mineralization. A total of 24 dogs with 26 liposarcomas were sampled. Mean attenuation was +15.2 (SD = 22.3) Hounsfield units (HU) with a range of –36 to +47.5 HU based on representative regions of interest. Twenty tumors (77%) contained focal areas of fat attenuation. All masses enhanced with contrast medium administration, which is distinct from what has been reported previously in infiltrative lipomas. Other CT features associated with canine liposarcomas included heterogeneous internal attenuation (81%) and lack of a clearly defined capsule (38%) suggesting infiltration of local structures. Six tumors (23%) had foci of mineralization. Findings from the current study indicated that liposarcoma should be considered as a differential diagnosis for mixed‐attenuation, contrast‐enhancing masses in dogs that contain at least one focus of fat attenuation on precontrast images; however, presence of foci of fat attenuation was not a necessary finding for the diagnosis of canine liposarcoma.
    Type of Medium: Online Resource
    ISSN: 1058-8183 , 1740-8261
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2142058-0
    SSG: 22
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  • 4
    Online Resource
    Online Resource
    American Veterinary Medical Association (AVMA) ; 2019
    In:  American Journal of Veterinary Research Vol. 80, No. 7 ( 2019-07), p. 657-662
    In: American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 80, No. 7 ( 2019-07), p. 657-662
    Abstract: To use duplex Doppler ultrasonography to compare gastrointestinal activity in healthy sedated versus nonsedated rabbits and to evaluate agreement between B-mode and pulsed-wave Doppler (PWD) ultrasonographic measurements. ANIMALS 10 healthy client-owned rabbits brought for routine physical examination and 11 brought for routine ovariohysterectomy or castration. PROCEDURES Duplex Doppler ultrasonography of the gastrointestinal tract was performed once for the 10 rabbits that underwent physical examination and twice (before and after presurgical sedation) for the 11 rabbits that underwent routine ovariohysterectomy or castration. Mean number of peristaltic contractions during a 30-second period was determined for the stomach, duodenum, jejunum, cecum, and colon from B-mode and PWD ultrasonographic images that had been video recorded. Findings for the duodenum and jejunum were compared between B-mode and PWD ultrasonography and between sedated and nonsedated rabbits. RESULTS Duodenal and jejunal segments had measurable peristaltic waves; however, the stomach, cecum, and colon had no consistent measurable activity. B-mode and PWD ultrasonographic measurements for the duodenum and jejunum had high agreement. No significant difference was identified between nonsedated and sedated rabbits in mean number of peristaltic contractions of the duodenum or jejunum. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that both B-mode and PWD ultrasonography of the duodenum and jejunum may be suitable for noninvasive evaluation of small intestinal motility in rabbits and that the sedation protocol used in this study had no impact on measured peristaltic values.
    Type of Medium: Online Resource
    ISSN: 0002-9645
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2019
    detail.hit.zdb_id: 2056942-7
    SSG: 22
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  • 5
    Online Resource
    Online Resource
    Elsevier BV ; 2018
    In:  Veterinary Clinics of North America: Equine Practice Vol. 34, No. 2 ( 2018-08), p. 215-234
    In: Veterinary Clinics of North America: Equine Practice, Elsevier BV, Vol. 34, No. 2 ( 2018-08), p. 215-234
    Type of Medium: Online Resource
    ISSN: 0749-0739
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    SSG: 21,22
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  • 6
    In: Stem Cell Research & Therapy, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2022-05-16)
    Abstract: Mesenchymal stem cells (MSCs) have shown promising results in stimulating cartilage repair and in the treatment of osteoarthritis (OA). However, the fate of the MSCs after intra-articular injection and their role in cartilage regeneration is not clear. To address these questions, this study investigated (1) homing of labeled human adipose tissue derived integrin α10β1-selected MSCs (integrin α10-MSCs) to a cartilage defect in a rabbit model and (2) the ability of the integrin α10-MSCs to differentiate to chondrocytes and to produce cartilage matrix molecules in vivo. Design Integrin α10-MSCs were labeled with superparamagnetic iron oxide nanoparticles (SPIONs) co-conjugated with Rhodamine B to allow visualization by both MRI and fluorescence microscopy. A cartilage defect was created in the articular cartilage of the intertrochlear groove of the femur of rabbits. Seven days post-surgery, labeled integrin α10-MSCs or vehicle were injected into the joint. Migration and distribution of the SPION-labeled integrin α10-MSCs was evaluated by high-field 9.4 T MRI up to 10 days after injection. Tissue sections from the repair tissue in the defects were examined by fluorescence microscopy. Results In vitro characterization of the labeled integrin α10-MSCs demonstrated maintained viability, proliferation rate and trilineage differentiation capacity compared to unlabeled MSCs. In vivo MRI analysis detected the labeled integrin α10-MSCs in the cartilage defects at all time points from 12 h after injection until day 10 with a peak concentration between day 1 and 4 after injection. The labeled MSCs were also detected lining the synovial membrane at the early time points. Fluorescence analysis confirmed the presence of the labeled integrin α10-MSCs in all layers of the cartilage repair tissue and showed co-localization between the labeled cells and the specific cartilage molecules aggrecan and collagen type II indicating in vivo differentiation of the MSCs to chondrocyte-like cells. No adverse effects of the α10-MSC treatment were detected during the study period. Conclusion Our results demonstrated migration and homing of human integrin α10β1-selected MSCs to cartilage defects in the rabbit knee after intra-articular administration as well as chondrogenic differentiation of the MSCs in the regenerated cartilage tissue.
    Type of Medium: Online Resource
    ISSN: 1757-6512
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2548671-8
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  • 7
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2018
    In:  Veterinary and Comparative Orthopaedics and Traumatology Vol. 31, No. S 02 ( 2018-07), p. A1-A25
    In: Veterinary and Comparative Orthopaedics and Traumatology, Georg Thieme Verlag KG, Vol. 31, No. S 02 ( 2018-07), p. A1-A25
    Type of Medium: Online Resource
    ISSN: 0932-0814 , 2567-6911
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2018
    SSG: 22
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  • 8
    In: Veterinary Radiology & Ultrasound, Wiley, Vol. 56, No. 3 ( 2015-05), p. 272-277
    Abstract: Primary pulmonary neoplasia is relatively uncommon in cats and generally has a poor prognosis. In this multicenter, retrospective study of 57 cats with pulmonary neoplasia, the most frequent presenting signs were anorexia/inappetence (39%) and cough (37%). The pulmonary tumors were considered to be incidental findings in 9% cats. In computed tomographic (CT) images, primary pulmonary tumors appeared as a pulmonary mass in 55 (96%) cats and as a disseminated pulmonary lesion without a defined mass in two (4%) cats. Most pulmonary tumors were in the caudal lobes, with 28 (49%) in the right caudal lobe and 17 (30%) in the left caudal lobe. CT features associated with pulmonary tumors included mass in contact with visceral pleura (96%), irregular margins (83%), well‐defined borders (79%), bronchial compression (74%), gas‐containing cavities (63%), foci of mineral attenuation (56%), and bronchial invasion (19%). The mean (range) maximal dimension of the pulmonary masses was 3.5 cm (1.1–11.5 cm). Additional foci of pulmonary disease compatible with metastasis were observed in 53% cats. Pleural fluid was evident in 30% cats and pulmonary thrombosis in 12% cats. The histologic diagnoses were 47 (82%) adenocarcinomas, six (11%) tumors of bronchial origin, three (5%) adenosquamous cell carcinomas, and one (2%) squamous cell carcinoma. In this series, adenocarcinoma was the predominant tumor type, but shared many features with less common tumor types. No associations were identified between tumor type and CT features. Prevalence of suspected intrapulmonary metastasis was higher than in previous radiographic studies of cats with lung tumors.
    Type of Medium: Online Resource
    ISSN: 1058-8183 , 1740-8261
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2142058-0
    SSG: 22
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  • 9
    In: Animals, MDPI AG, Vol. 10, No. 3 ( 2020-03-18), p. 506-
    Abstract: Joint pain and osteoarthritis (OA) are some of the most common causes of lameness in horses, and most of the available treatments focus on symptomatic relief without a disease-modifying effect. TRPV1 is a potential target for treating joint diseases, including OA, and the present study aims to investigate if the TRPV1 receptor is present in equine articular tissue and determine whether the number of receptors is upregulated in joint inflammation. Metacarpo/metatarsophalangeal (MCP/MTP) joints from 15 horses euthanised for reasons unrelated to this study were included. Based on synovial fluid analysis, macroscopic evaluation, and magnetic resonance imaging (MRI), joints were divided into two groups: healthy joints and joints with pathology. ELISA analysis was performed on synovial tissue harvested from all joints. TPRV1 was found in all joints. The mean concentration of TRPV1 compared to total protein in healthy joints (8.4 × 10−7 ng/mL) and joints with pathology (12.9 × 10−7 ng/mL) differed significantly (p = 0.01, t-test with Welch correction). Quantitative real-time reverse transcriptase PCR analysis was performed on RNA isolates from synovial tissue from all joints. TRPV1 mRNA expression ratio normalized to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in healthy joints (0.16 (SD: 0.19)) and joints with pathology (0.24 (SD: 0.14)) did not differ significantly (p = 0.43, t-test with Welch correction). mRNA expression of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) was very low for both groups. In conclusion, TRPV1 was detected both on mRNA and the protein level, with a higher expression of TRPV1 in samples from joints with pathology. Future studies will determine the clinical potential of equine TRPV1 as a target in the management of joint pain and inflammation.
    Type of Medium: Online Resource
    ISSN: 2076-2615
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2606558-7
    SSG: 23
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