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  • 1
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    Online Resource
    Serum paraoxonase‐1 activities and oxidative status in patients with plaque‐type psoriasis with/without metabolic syndrome
    Wiley ; 2011
    In:  Journal of Clinical Laboratory Analysis Vol. 25, No. 4 ( 2011-01), p. 289-295
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 25, No. 4 ( 2011-01), p. 289-295
    Abstract: Objective : Psoriasis is a chronic immune‐mediated inflammatory skin disease associated with metabolic syndrome, which is made up of a cluster of disorders, including obesity, diabetes mellitus, dyslipidemia, and cardiovascular disease. The aim of this study was to investigate serum paraoxonase‐1 activities and oxidative status parameters in patients with plaque‐type psoriasis with or without metabolic syndrome. Methods : In this study, patients with plaque‐type psoriasis with ( n =25) or without ( n =27) metabolic syndrome, according to the criteria of the International Diabetes Federation (IDF), were matched for age and sex to an equally sized control group ( n =25). Results : In patients without metabolic syndrome, serum paraoxonase and arylesterase activities showed mean decreases of 29 and 6%, respectively, whereas in patients with metabolic syndrome, the mean decreases in the enzymes' activities were 35 and 11%, respectively, compared with those in the control group. Serum total antioxidant capacity and total oxidant status were not statistically significant in any of the three groups. Multiple linear regression analysis revealed that HDL cholesterol and log‐transformed triglyceride were independent variables for serum arylesterase activity and that fasting glucose and diastolic blood pressure were independent variables for serum paraoxonase activity. Conclusions : These results suggest that according to the criteria of the IDF, the significant decrease observed in serum paraoxonase activity was independent of the metabolic syndrome in patients with mild‐to‐moderate plaque‐type psoriasis, whereas the significant decrease in serum arylesterase activity was associated with the metabolic syndrome. J. Clin. Lab. Anal. 25:289–295, 2011. © 2011 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v25.4
    DOI: 10.1002/jcla.20471
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2001635-9
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  • 2
    Online Resource
    Online Resource
    Insulin resistance in non-diabetic obese patients
    Elsevier BV ; 2009
    In:  Clinical Biochemistry Vol. 42, No. 4-5 ( 2009-3), p. 344-345
    Details
    In: Clinical Biochemistry, Elsevier BV, Vol. 42, No. 4-5 ( 2009-3), p. 344-345
    Type of Medium: Online Resource
    ISSN: 0009-9120
    URL: Article
    DOI: 10.1016/j.clinbiochem.2008.09.079
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2009
    detail.hit.zdb_id: 1496880-0
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  • 3
    Online Resource
    Online Resource
    Assessment of average of normals for vitamin B12
    Elsevier BV ; 2009
    In:  Clinical Biochemistry Vol. 42, No. 4-5 ( 2009-3), p. 336-
    Details
    In: Clinical Biochemistry, Elsevier BV, Vol. 42, No. 4-5 ( 2009-3), p. 336-
    Type of Medium: Online Resource
    ISSN: 0009-9120
    URL: Article
    DOI: 10.1016/j.clinbiochem.2008.09.068
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2009
    detail.hit.zdb_id: 1496880-0
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  • 4
    Online Resource
    Online Resource
    SARS-CoV-2 Pneumonia Affects Male Reproductive Hormone Levels: A Prospective, Cohort Study
    Oxford University Press (OUP) ; 2021
    In:  The Journal of Sexual Medicine Vol. 18, No. 2 ( 2021-02), p. 256-264
    Details
    In: The Journal of Sexual Medicine, Oxford University Press (OUP), Vol. 18, No. 2 ( 2021-02), p. 256-264
    Type of Medium: Online Resource
    ISSN: 1743-6095
    URL: Article
    DOI: 10.1016/j.jsxm.2020.11.007
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
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  • 5
    Online Resource
    Online Resource
    Activated Protein C Resistance and Lipoprotein (a) in Young Adults With Branch Retinal Vein Occlusion
    Springer Science and Business Media LLC ; 2005
    In:  Annals Of Ophthalmology Vol. 37, No. 4 ( 2005), p. 267-272
    Details
    In: Annals Of Ophthalmology, Springer Science and Business Media LLC, Vol. 37, No. 4 ( 2005), p. 267-272
    Type of Medium: Online Resource
    ISSN: 1530-4086
    URL: Issue
    URL: Article
    DOI: 10.1385/AO:37:4
    DOI: 10.1385/AO:37:4:267
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2005
    detail.hit.zdb_id: 2187236-3
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  • 6
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    Online Resource
    Serum fetuin-A and RANKL levels in patients with early stage breast cancer
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2023
    In:  Journal of Medical Biochemistry Vol. 42, No. 2 ( 2023), p. 249-257
    Details
    In: Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 42, No. 2 ( 2023), p. 249-257
    Abstract: Background: Breast cancer (BC) is the primary cause of mortality due to cancer in females around the world. Fetuin-A is known to increase metastases over signals and peroxisomes related with growing. Receptor activator of nuclear factor-kB ligand (RANKL) takes part in cell adhesion, and RANKL inhibition is used in the management of cancer. We aimed to examine the relationship between serum fetuin-A, RANKL levels, other laboratory parameters and clinical findings in women diagnosed with early stage BC, in our population. Methods: Women having early stage BC (n=117) met our study inclusion criteria as they had no any anti-cancer therapy before. Thirty-seven healthy women controls were also confirmed with breast examination and ultrasonography and/or mammography according to their ages. Serum samples were stored at -80 °C and analysed via ELISA. Results: Median age of the patients was 53 (range: 57-86) while it was 47 (range: 23-74) in the healthy group. Patients had lower high-density lipoprotein levels (p=0.002) and higher neutrophil counts (p=0.014). Fetuin-A and RANKL levels did not differ between the groups (p=0.116 and p=0.439, respectively) but RANKL leves were found to be lower in the favorable histological subtypes (p=0.04). Conclusions: In this study, we found no correlation between serum fetuin-A levels and clinical findings in patients diagnosed with early stage BC. However, RANKL levels are found to be lower in subgroups with favorable histopathologic subtypes such as tubular, papillary and mucinous BC and there was statistically significant difference.
    Type of Medium: Online Resource
    ISSN: 1452-8258 , 1452-8266
    Uniform Title: Serum fetuin-A i nivoi RANKLa kod pacijenata sa ranim stadijom raka dojke
    URL: Article
    DOI: 10.5937/jomb0-37386
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2023
    detail.hit.zdb_id: 2405112-3
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  • 7
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    Online Resource
    Anti-CCP Antibodies Are Not Associated with Familial Mediterranean Fever in Childhood
    Hindawi Limited ; 2013
    In:  International Journal of Rheumatology Vol. 2013 ( 2013), p. 1-4
    Details
    In: International Journal of Rheumatology, Hindawi Limited, Vol. 2013 ( 2013), p. 1-4
    Abstract: Objective . Anticyclic citrullinated peptide antibodies (anti-CCP) testing is useful in the diagnosis of rheumatoid arthritis (RA) with high specificity. Arthritis is a very common clinical manifestation in children with familial Mediterranean fever (FMF). The aim of the study was to show the presence of anti-CCP antibodies in child individuals diagnosed with FMF. Material and Methods . The study groups comprised one hundred and twenty-six patients (126) diagnosed with FMF (female/male ( n ): 66/60) and 50 healthy controls (female/male ( n ): 25/25). Clinical and laboratory assessments of the FMF patients were performed during attack-free periods. Erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), fibrinogen, and anti-CCP antibody levels were measured. Results . Anti-CCP was negative in healthy controls and also in all FMF patients. There was not a significant difference in anti-CCP between the patient and the control groups. Our study has shown that anti-CCP was correlated moderately with age ( rs = 0.271 ; P = 0.0020 ), duration of illness ( rs = 0.331 ; P 〈 0.0001 ), and colchicine therapy ( rs = 0.259 ; P = 0.004 ). Conclusion . Our data show that anti-CCP antibodies are not associated with FMF. Anti-CCP does not have a priority for identifying FMF arthritis from the other inflammatory arthritis.
    Type of Medium: Online Resource
    ISSN: 1687-9260 , 1687-9279
    URL: Article
    DOI: 10.1155/2013/498581
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2503284-7
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  • 8
    Online Resource
    Online Resource
    Evaluation of oxidant/antioxidant status and ECP levels in asthma
    The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS ; 2010
    In:  Turkish Journal of Medical Sciences
    Details
    In: Turkish Journal of Medical Sciences, The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS
    Type of Medium: Online Resource
    ISSN: 1303-6165
    URL: Article
    DOI: 10.3906/sag-0906-6
    Language: English
    Publisher: The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS
    Publication Date: 2010
    detail.hit.zdb_id: 2046475-7
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  • 9
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    Association of serum fetuin-A levels with heart valve calcification and other biomarkers of inflammation among persons with acute coronary syndrome
    University of Toronto Libraries - UOTL ; 2012
    In:  Clinical & Investigative Medicine Vol. 35, No. 4 ( 2012-08-04), p. 206-
    Details
    In: Clinical & Investigative Medicine, University of Toronto Libraries - UOTL, Vol. 35, No. 4 ( 2012-08-04), p. 206-
    Abstract: Purpose: Fetuin-A is a multifunctional hepatic secretory protein that inhibits dystrophic vascular and valvular calcification. Our aim was to evaluate the relationship among fetuin-A levels, heart valve calcification and other biomarkers of inflammation in patients with acute coronary syndrome (ACS). Methods: The associations among serum fetuin-A concentrations, mitral annular (MAC) and aortic valve calcification and other biomarkers of inflammation (hs-CRP, ferritin, fibrinogen, white blood cell count (WBC), erythrocyte sedimentation rate (ESR), albumin levels) were evaluated in ACS patients and healthy controls. The study included 95 patients (mean age 61 .8±12.10 years) and 81 healthy controls (mean age 48.33±9.19 years). Results: Fetuin-A levels were significantly lower in patients with ACS than in healthy controls (0.76 ± 0.23 and 1.10 ± 0.45 g/L, respectively; p 〈 0.001). Fetuin-A was lower in patients with mitral annular calcification (p=0.007) and aortic (p=0.001) valve calcification. In patients with ACS, there was a negative correlation among serum urea (r=-0.377; p 〈 0.001) and creatinine (r=-0.232; p=0.024) levels and fetuin-A, and a negative correlation among WBC (r=-0.156; p=0,132), ESR (r=-0.214; p=0.037), hs-CRP (r=-0.220; p=0.032) levels and fetuin-A. A positive correlation was seen between albumin and fetuin-A (r=0.362; p 〈 0.001). Multivariate logistic regression analysis revealed that fetuin-A was the variable that had a significant effect on ACS (p = 0.020 OR = .015; (95% CI)(0.000–0.520). Conclusion: Fetuin-A levels decrease in patients with acute coronary syndromes, independent of heart valve calcification. Fetuin-A may therefore act as a negative acute phase protein after myocardial infarction.
    Type of Medium: Online Resource
    ISSN: 1488-2353
    URL: Article
    DOI: 10.25011/cim.v35i4.17149
    Language: Unknown
    Publisher: University of Toronto Libraries - UOTL
    Publication Date: 2012
    detail.hit.zdb_id: 2067562-8
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  • 10
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    Online Resource
    Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus
    University of Toronto Libraries - UOTL ; 2011
    In:  Clinical & Investigative Medicine Vol. 34, No. 3 ( 2011-06-01), p. 163-
    Details
    In: Clinical & Investigative Medicine, University of Toronto Libraries - UOTL, Vol. 34, No. 3 ( 2011-06-01), p. 163-
    Abstract: Purpose: The purpose of this study was to determine the effects of diabetic complications on oxidation of proteins, lipids, and DNA and to investigate the relationship between oxidative damage markers and clinical parameters. Methods: The study group consisted of 69 type 2 diabetic patients (20 patients without complication, 49 patients with complication) who attended internal medicine outpatient clinics of Istanbul Education and Research Hospital and 19 healthy control subjects. In serum samples of both diabetic patients and healthy subjects, 8-hydroxy-2’deoxyguanosine (8-OHdG), as a marker of oxidative DNA damage, Nε-(hexanoyl)lysine (HEL) and 15-F2t-iso-prostaglandin (15-F2t-IsoP). as products of lipooxidative damage, advanced oxidation protein products (AOPP), as markers of protein damage, and paraoxonase1 (PON1) as antioxidant were studied. Results: 15-F2t-IsoP (p 〈 0.005) and AOPP (p 〈 0.001) levels were significantly higher in diabetic group than control group while there were no significant differences in levels of 8-OHdG and HEL between the two groups. AOPP (p 〈 0.001) and 8-OHdG (p 〈 0.001) were significantly higher in diabetic group with complications compared to diabetic group without complications. Conclusions: Increased formation of free radicals and oxidative stress, under conditions of hyperglycaemia, is one of the probable causes for evolution of complications in diabetes mellitus. Our study supports the hypothesis that oxidant/antioxidant balance is disturbed in diabetic patients.
    Type of Medium: Online Resource
    ISSN: 1488-2353
    URL: Article
    DOI: 10.25011/cim.v34i3.15189
    Language: Unknown
    Publisher: University of Toronto Libraries - UOTL
    Publication Date: 2011
    detail.hit.zdb_id: 2067562-8
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