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  • 1
    In: JAMA Network Open, American Medical Association (AMA), Vol. 5, No. 9 ( 2022-09-26), p. e2233342-
    Abstract: Gaps in readiness for indirect supervision have been identified for essential responsibilities encountered early in residency, presenting risks to patient safety. Core Entrustable Professional Activities (EPAs) for entering residency have been proposed as a framework to address these gaps and strengthen the transition from medical school to residency. Objective To assess progress in developing an entrustment process in the Core EPAs framework. Design, Setting, and Participants In this quality improvement study in the Core EPAs for Entering Residency Pilot, trained faculty made theoretical entrustment determinations and recorded the number of workplace-based assessments (WBAs) available for each determination in 2019 and 2020. Four participating schools attempted entrustment decision-making for all graduating students or a randomly selected subset of students. Deidentified, individual-level data were merged into a multischool database. Interventions Schools implemented EPA-related curriculum, WBAs, and faculty development; developed systems to compile and display data; and convened groups to make theoretical summative entrustment determinations. Main Outcomes and Measures On an EPA-specific basis, the percentage of students for whom an entrustment determination could be made, the percentage of students ready for indirect supervision, and the volume of WBAs available were recorded. Results Four participating schools made 4525 EPA-specific readiness determinations (2296 determinations in 2019 and 2229 determinations in 2020) for 732 graduating students (349 students in 2019 and 383 students in 2020). Across all EPAs, the proportion of determinations of “ready for indirect supervision” increased from 2019 to 2020 (997 determinations [43.4%] vs 1340 determinations [60.1%] ; 16.7 percentage point increase; 95% CI, 13.8-19.6 percentage points; P   & amp;lt; .001), as did the proportion of determinations for which there were 4 or more WBAs (456 of 2295 determinations with WBA data [19.9%] vs 938 [42.1%] ; 22.2 percentage point increase; 95% CI, 19.6-24.8 percentage points; P   & amp;lt; .001). The proportion of EPA-specific data sets considered for which an entrustment determination could be made increased from 1731 determinations (75.4%) in 2019 to 2010 determinations (90.2%) in 2020 (14.8 percentage point increase; 95% CI, 12.6-16.9 percentage points; P   & amp;lt; .001). On an EPA-specific basis, there were 5 EPAs (EPA 4 [orders], EPA 8 [handovers] , EPA 10 [urgent care], EPA 11 [informed consent] , and EPA 13 [patient safety]) for which few students were deemed ready for indirect supervision and for which there were few WBAs available per student in either year. For example, for EPA 13, 0 of 125 students were deemed ready in 2019 and 0 of 127 students were deemed ready in 2020, while 0 determinations in either year included 4 or more WBAs. Conclusions and Relevance These findings suggest that there was progress in WBA data collected, the extent to which entrustment determinations could be made, and proportions of entrustment determinations reported as ready for indirect supervision. However, important gaps remained, particularly for a subset of Core EPAs.
    Type of Medium: Online Resource
    ISSN: 2574-3805
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2022
    detail.hit.zdb_id: 2931249-8
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2004
    In:  The American Journal of Sports Medicine Vol. 32, No. 6 ( 2004-09), p. 1440-1450
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 32, No. 6 ( 2004-09), p. 1440-1450
    Abstract: Osteochondral transfer procedures are increasingly used to resurface full-thickness articular cartilage defects. There has not been long-term assessment/description of autogenous donor and recipient sites. Hypothesis The healing process occurs at the donor/host cartilage and bone interfaces. Study Design Histologic, biochemical, and biomechanical changes were assessed 6 months after an osteochondral transfer in a goat model. Methods Eight adult goats were studied. In the 6 osteochondral transfer goats, 2 autogenous plugs were transferred from the femoral trochlea to defects in the weightbearing portion of the medial femoral condyle. The goats were allowed free range for 6 months. Randomly assigned plugs were assessed. Results Knees of the sacrificed animals had preservation of the joint space with mild chondromalacic changes in both transfer and contralateral control groups. Histologically, no evidence of cartilage (host/donor) healing was seen. Subchondral bone of the plug was contiguous with the surrounding recipient bone. Cellular viability in the autogenous osteochondral plug was seen, and 35SO4 uptake of the articular cartilage was not statistically different from the contralateral control condyle. The indentation stiffness of the transfer plug (mosaicplasty) and the contralateral donor site were similar—much stiffer than normal cartilage including surrounding condylar cartilage. Large structural stiffness of transferred cores and donor sites appeared to be related to their thinner cartilage layer. Conclusions At 6-month follow-up, a cleft between host and transferred articular regions remained, with no integration between the two. Clinical Relevance Autogenous transplantation of osteochondral plugs is possible with integration of subchondral bone and preservation of chondral viability.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 1997
    In:  The American Journal of Sports Medicine Vol. 25, No. 4 ( 1997-07), p. 560-569
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 25, No. 4 ( 1997-07), p. 560-569
    Abstract: The goal of this study was to evaluate, histologically and biochemically, repair of the articular cartilage in a rabbit joint after the use of the holmium:yttrium-alumi num-garnet laser in a cartilage chondroplasty model. In 30 New Zealand White rabbits, chondroplasty was per formed with the laser at an intensity of 0.8 J at a rate of 10 Hz. The animals were sacrificed 12 weeks after surgery. Histologically, the safranin O staining index of proteoglycan correlated well with the biochemical re sults, illustrating a decrease of proteoglycan in the repaired articular cartilage after laser articular cartilage chondroplasty. The damaged articular cartilage sur face after the laser application was extensive. The damaged area observed was gradually distributed along the radius from the central point of the laser beam application. Biochemically, the amount of glycos aminoglycan in the repaired tissue (8 ± 2 mg of hex osamine per gram of dry cartilage) was statistically less when compared with that in the sham-treated tissue (40 ± 5 mg). The amount of sulfate incorporated into proteoglycans was 8 to 10 times less in the chondro plasty model compared with the control, suggesting that cell viability was greatly reduced in the treated tissues or expression of proteoglycans was greatly reduced. In the subchondral area, histologic evaluation showed the lack of osteocytes in lacunae of the bone tissue after use of laser energy. The architecture of the subchondral bone in the chondroplasty area was dam aged, with damage also seen in the membranes of the blood vessels.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1997
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 4
    Online Resource
    Online Resource
    Elsevier BV ; 2000
    In:  Journal of Orthopaedic Science Vol. 5, No. 2 ( 2000-03), p. 157-164
    In: Journal of Orthopaedic Science, Elsevier BV, Vol. 5, No. 2 ( 2000-03), p. 157-164
    Type of Medium: Online Resource
    ISSN: 0949-2658
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2000
    detail.hit.zdb_id: 1481657-X
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  • 5
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 28, No. 1 ( 2000-01), p. 90-97
    Abstract: To assess the effect of hyaluronan on meniscus injury and repair, we had 35 mature New Zealand White rabbits undergo bilateral meniscus injury and repair (19 in the peripheral region, and 16 in the inner region). A longitudinal tear was created in the medial meniscus and repaired with horizontally placed nylon sutures. The left knee joint received intraarticular injections of hyaluronan 1 week after surgery and once a week for 5 weeks. The right knees were injected with phosphate-buffered saline (the carrier vehicle of the hyaluronan). Twelve weeks after repair, tears in the peripheral region showed gross and histologic evidence of healing, with no difference between the vehicle- and hyaluronan-treated menisci. Biochemically, the ratio of reducible collagen cross-links in the hyaluronan-treated menisci was significantly higher than in the vehicle-treated menisci, indicating greater level of collagen remodeling. Biomechanically the vehicle- and hyaluronan-treated menisci demonstrated similarly high tearing load and fracture toughness. In the inner region, poor healing response was observed grossly and histologically in both treatment groups. Water content in the hyaluronan-treated menisci was significantly lower than in the vehicle-treated menisci, indicating a lower level of swelling. Hyaluronan treatment stimulated collagen remodeling in the peripheral region and inhibited swelling of the meniscus repaired in the inner region.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 6
    Online Resource
    Online Resource
    Universidad Nacional Mayor de San Marcos, Vicerectorado de Investigacion ; 1999
    In:  Ciencia e Investigación Vol. 2, No. 2 ( 1999-12-31), p. 67-79
    In: Ciencia e Investigación, Universidad Nacional Mayor de San Marcos, Vicerectorado de Investigacion, Vol. 2, No. 2 ( 1999-12-31), p. 67-79
    Abstract: El objetivo del presente trabajo fue aislar e identificar los alcaloides de las hojas de Ruta Graveolens L., y relacionar sus estructuras químicas con la actividad mutagénica de las hojas, demostrada en un trabajo anterior. Se aislaron 4 alcaloides, denominados "A", "1", "2" y "3", que fueron elucidados estructuralmente mediante espectroscopfa UV e IR, además de sus constantes fisicas y reacciones químicas. El alcaloide "A" fue identificado como alcaloide acridónico, los alcaloides 1 y 2 fueron identificados como alcaloides furoquínolínícos y el alcaloide "3" fue considerado como alcaloide quinolónico. Debido a su alto rendimiento y estructura química, se considera al alcaloide "A" como el principal responsable de la actividad mutagénica de las hojas de Ruta Graveolens L., mientras que los alcaloides "1" y "2" debido al bajo rendimiento, posiblemente no participen en la mutagenicidad del extracto por ausencia de pruebas sobre su estructura.
    Type of Medium: Online Resource
    ISSN: 1609-9044 , 1561-0861
    Language: Unknown
    Publisher: Universidad Nacional Mayor de San Marcos, Vicerectorado de Investigacion
    Publication Date: 1999
    detail.hit.zdb_id: 2122378-6
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2001
    In:  The American Journal of Sports Medicine Vol. 29, No. 6 ( 2001-11), p. 704-708
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 29, No. 6 ( 2001-11), p. 704-708
    Abstract: A long-term in vivo study was performed to assess biochemical changes after laser repair of articular cartilage. Forty New Zealand White rabbits were sacrificed 26 weeks after undergoing an articular cartilage chondroplasty with use of a holmium:yttrium-aluminum-garnet laser at 0.8 joules per pulse and a rate of 10 Hz. Glycosaminoglycan content in the repaired tissue decreased significantly with both perpendicular (19.59 ± 5.6 μg hexosamin/mg of dry tissue) and tangential delivery (14.78 ± 4.5 μg/mg) compared with the sham-treated tissue (39.6 ± 5.0 μg/mg). Cellular viability was also significantly decreased. Sulfate incorporation was decreased to 203 ± 142 cpm/mg of dry cartilage in the tangential mode and 461 ± 209 cpm/mg in the tangential mode, compared with the sham at 1845 cpm/mg. Uptake of [3H]thymidine decreased to 463 ± 473 cpm/mg of dry tissue and 455 ± 170 cpm/mg in the tangential and perpendicular modes, respectively, compared with 2465 cpm/mg in the sham tissue. There were no significant differences between the tangential and perpendicular delivery modes in any assessments performed. The short-term chondrocyte destruction previously noted in a 12-week study after laser treatment was not reversed during a longer-term 26-week study, and cellular viability was not recovered, suggesting that the loss of chondrocyte function may be permanent.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 8
    Online Resource
    Online Resource
    Elsevier BV ; 1997
    In:  Journal of Orthopaedic Science Vol. 2, No. 3 ( 1997-05), p. 171-179
    In: Journal of Orthopaedic Science, Elsevier BV, Vol. 2, No. 3 ( 1997-05), p. 171-179
    Type of Medium: Online Resource
    ISSN: 0949-2658
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1997
    detail.hit.zdb_id: 1481657-X
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  • 9
    In: Arthroscopy: The Journal of Arthroscopic & Related Surgery, Elsevier BV, Vol. 17, No. 8 ( 2001-10), p. 856-863
    Type of Medium: Online Resource
    ISSN: 0749-8063
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2001
    detail.hit.zdb_id: 1491233-8
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  • 10
    In: Arthroscopy: The Journal of Arthroscopic and Related Surgery, Elsevier BV, Vol. 17, No. 8 ( 2001-10), p. 856-863
    Type of Medium: Online Resource
    ISSN: 0749-8063
    Language: Unknown
    Publisher: Elsevier BV
    Publication Date: 2001
    detail.hit.zdb_id: 1491233-8
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