In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 1 ( 2022-1-27), p. e0263139-
Abstract:
The main purpose of this study was to investigate the pooled prevalence of prediabetes and type-2 diabetes in the general population of Malaysia. Method We systematically searched Medline (PubMed), Embase, Web of Science, Google Scholar and Malaysian Journals Online to identify relevant studies published between January 1, 1995, and November 30, 2021, on the prevalence of type-2 diabetes in Malaysia. Random-effects meta-analyses were used to obtain the pooled prevalence of diabetes and prediabetes. Subgroup analyses also used to analyze to the potential sources of heterogeneity. Meta- regression was carried to assess associations between study characteristics and diabetes prevalence. Three independent authors selected studies and conducted the quality assessment. The quality of the final evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Results Of 2689 potentially relevant studies, 786 titles and abstract were screened. Fifteen studies with 103063 individuals were eligible to be included in the meta-analyses. The pooled prevalence of diabetes was 14.39% (95% CI, 12.51%–16.38%; I 2 = 98.4%, 103063 participants from 15 studies). The pooled prevalence of prediabetes was 11.62% (95% CI, 7.17%–16.97%; I 2 = 99.8, 88702 participants from 9 studies). The subgroup analysis showed statistically significant differences in diabetes prevalence by the ethical sub-populations with highest in Indians (25.10%; 95% CI, 20.19%–30.35%), followed by Malays (15.25%; 95% CI, 11.59%–19.29%), Chinese (12.87%; 95% CI, 9.73%–16.37%), Bumiputeras (8.62%; 95% CI, 5.41%–12.47%) and others (6.91%; 95% CI, 5.71%–8.19%). There was no evidence of publication bias, although heterogeneity was high (I 2 ranged from 0.00% to 99·8%). The quality of evidence based on GRADE was low. Conclusions Results of this study suggest that a high prevalence of prediabetes and diabetes in Malaysia. The diabetes prevalence is associated with time period and increasing age. The Malaysian government should develop a comprehensive approach and strategy to enhance diabetes awareness, control, prevention, and treatment. Trial registration Trial registration no. PROSPERO CRD42021255894; https://clinicaltrials.gov/ .
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0263139
DOI:
10.1371/journal.pone.0263139.g001
DOI:
10.1371/journal.pone.0263139.g002
DOI:
10.1371/journal.pone.0263139.g003
DOI:
10.1371/journal.pone.0263139.g004
DOI:
10.1371/journal.pone.0263139.g005
DOI:
10.1371/journal.pone.0263139.t001
DOI:
10.1371/journal.pone.0263139.t002
DOI:
10.1371/journal.pone.0263139.t003
DOI:
10.1371/journal.pone.0263139.t004
DOI:
10.1371/journal.pone.0263139.s001
DOI:
10.1371/journal.pone.0263139.s002
DOI:
10.1371/journal.pone.0263139.s003
DOI:
10.1371/journal.pone.0263139.s004
DOI:
10.1371/journal.pone.0263139.r001
DOI:
10.1371/journal.pone.0263139.r002
DOI:
10.1371/journal.pone.0263139.r003
DOI:
10.1371/journal.pone.0263139.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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