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  • 1
    Online Resource
    Online Resource
    Newly synthesized palladium( ii ) complexes with aminothiazole derivatives: in vitro study of antimicrobial activity and antitumor activity on the human prostate cancer cell line
    Royal Society of Chemistry (RSC) ; 2022
    In:  Dalton Transactions Vol. 51, No. 3 ( 2022), p. 1191-1205
    Details
    In: Dalton Transactions, Royal Society of Chemistry (RSC), Vol. 51, No. 3 ( 2022), p. 1191-1205
    Abstract: Five new complexes of the palladium( ii ) ion (C1–C5) having the general formula [(PdL 2 )]Cl 2 with some 2-aminothiazoles (L1–L5), where L1 = 2-amino-4-(3,4-difluorophenyl)thiazole, L2 = 2-amino-5-methyl-4-phenylthiazole, L3 = 2-amino-4-phenylthiazole, L4 = 2-amino-4-(4-chlorophenyl)thiazole, and L5 = 2-amino-4-(2,4-difluorophenyl)thiazole, have been synthesized and characterized by elemental microanalysis and infrared, 1 H NMR and 13 C NMR spectroscopy. The in vitro antimicrobial activity of the five ligands and the corresponding Pd( ii ) complexes is investigated. Testing is performed by the microdilution method and the minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) have been determined. Testing is conducted against 11 microorganisms (nine strains of pathogenic bacteria and two yeast species). The tested ligands and palladium( ii ) complexes show selective, high and moderate activity. There is a difference in antimicrobial activity between the ligands and the corresponding palladium( ii ) complexes. The complexes have significant anti-staphylococcal activity and activity on Pseudomonas aeruginosa which is better than the positive control. The interactions of newly synthesized palladium( ii ) complexes with calf thymus DNA (CT-DNA) were investigated using UV-Vis absorption and fluorescence spectroscopy. Analysis of UV-absorption and fluorescence spectra indicates the formation of a complex between the palladium( ii ) complexes and DNA. The high values of intrinsic binding constants, K b , of the order 10 4 M −1 and Stern–Volmer quenching constants, K SV , of the order 10 5 M −1 indicated very good binding of all complexes to CT-DNA. Also, the new Pd( ii ) complexes show high cytotoxic activity towards the human prostate cancer cell line and insignificant activity towards non-cancerous human fibroblasts. Future research could additionally explore the biological activity of Pd( ii ) complexes presented in this paper and investigate the possibility of their implementation in clinical practice.
    Type of Medium: Online Resource
    ISSN: 1477-9226 , 1477-9234
    URL: Article
    DOI: 10.1039/D1DT03364F
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2022
    detail.hit.zdb_id: 1472887-4
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  • 2
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    Antimicrobial Treatment of Serratia marcescens Invasive Infections: Systematic Review
    MDPI AG ; 2023
    In:  Antibiotics Vol. 12, No. 2 ( 2023-02-09), p. 367-
    Details
    In: Antibiotics, MDPI AG, Vol. 12, No. 2 ( 2023-02-09), p. 367-
    Abstract: Background: Serratia marcescens (SM) is a Gram-negative pathogen discovered by Italian pharmacist, Bizio, in 1819. According to the literature, S. marcescens is resistant to a wide range of antibiotics, including penicillin, cephalosporin, tetracycline, macrolide, nitrofurantoin, and colistin. We conducted a systematic review of published reports, determined what invasive infections could cause SM, and established the most appropriate antibiotic therapy. Methods: We registered this systematic review on the PROSPERO registry of systematic reviews–meta-analyses before we started our research (registration number CRD42022323159). The online searches of published studies were implemented via MEDLINE, the Cochrane Central Register of Controlled Trials, EBSCO, Scopus, Google Scholar, SCIndex, and the registry of clinical studies of human participants (ClinicalTrials.gov). Results: Our study included 32 published articles (9 case series and 23 case reports). There were 57 individual cases, respectively. The oldest patient was 97 years and the youngest patient was a newborn. S. marcescens was, in most cases, isolated from blood followed by urine and cerebrospinal fluid. In most cases, sensitivity was tested to cotrimoxazole (from 27 isolates, 10 showed resistance) followed by gentamicin (from 26 isolates, 3 showed resistance) as well as amikacin (from 21 isolates, none showed resistance). Patients died from an infection in 21 cases (31%). Conclusions: Treatment of SM infections should include carbapenems or aminoglycosides in combination with third-generation (and eventually fourth-generation) cephalosporin. Cotrimoxazole should be considered in cases of uncomplicated urinary infections.
    Type of Medium: Online Resource
    ISSN: 2079-6382
    URL: Article
    DOI: 10.3390/antibiotics12020367
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2681345-2
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  • 3
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    Antimicrobial treatment of Morganella morganii invasive infections: Systematic review
    Elsevier BV ; 2021
    In:  Indian Journal of Medical Microbiology Vol. 39, No. 4 ( 2021-10), p. 404-412
    Details
    In: Indian Journal of Medical Microbiology, Elsevier BV, Vol. 39, No. 4 ( 2021-10), p. 404-412
    Type of Medium: Online Resource
    ISSN: 0255-0857
    URL: Article
    DOI: 10.1016/j.ijmmb.2021.06.005
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2129136-6
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  • 4
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    Synthesis, Characterization, and Investigation of Anti-Inflammatory and Cytotoxic Activities of Novel Thiourea Derivatives of Naproxen
    MDPI AG ; 2023
    In:  Pharmaceutics Vol. 16, No. 1 ( 2023-12-19), p. 1-
    Details
    In: Pharmaceutics, MDPI AG, Vol. 16, No. 1 ( 2023-12-19), p. 1-
    Abstract: The objective of this study was to synthesize seven novel thiourea derivatives of naproxen (8–14), examine the anti-inflammatory activity of the newly synthesized compounds, investigate the cytotoxic potential of both sets of synthesized compounds (1–7 and 8–14), and select the most promising anti-inflammatory and antitumor drug candidates. The results of the in vivo anti-inflammatory study clearly showed that compounds 8 and 9 were capable of decreasing paw edema, as evident from a high percentage of inhibition (44.83% and 49.29%, respectively). In addition, the results of in vitro enzyme inhibition assays demonstrated that neither of the newly synthesized compounds reached 50% inhibition of 5-LOX at concentrations lower than 100 µM. In terms of antitumor potential, derivatives 3 and 8 exhibited strong cytotoxic effects on the HeLa cell line, suggesting the involvement of the extrinsic pathway of apoptosis. According to the overall results obtained for both sets of synthesized molecules, derivatives 4 and 8 can be underlined as molecules with the strongest anti-inflammatory activity, while derivatives 3 and 8 are the most promising cytotoxic agents.
    Type of Medium: Online Resource
    ISSN: 1999-4923
    URL: Article
    DOI: 10.3390/pharmaceutics16010001
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2527217-2
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  • 5
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    Teucrium polium induces apoptosis in peripheral blood lymphocytes isolated from human chronic lymphocytic leukemia
    National Library of Serbia ; 2020
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 77, No. 12 ( 2020), p. 1252-1259
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 77, No. 12 ( 2020), p. 1252-1259
    Abstract: Background/Aim. Chronic lymhocytic leukemia (CLL) is considered more as a disease of cells accumulation due to the defect in apoptosis rather than deregulated cell?s proliferation. The activation of apoptosis is one of the main molecular mechanisms responsible for anti-cancer activities of most of the currently studied potential anti-cancer agents, including natural compounds. Teucrium polium (TP) extracts exhibited strong cytotoxic effects in murine leukemia cell line, RAW 264.7 and human melanoma cell line, C32, but their cytotoxic effects against human leukemia cells were unknown. Methods. The viability of human leukemia cell lines (MOLT 4 and JVM 13), lymphocytes isolated from 28 patients with CLL (CLL cells), and peripheral blood mononuclear cells (PBMCs) isolated from 16 healthy subjects treated with TP leaves methanolic extract, was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis of TP treated CLL cells was measured by flow cytometry applying Annexin V/7AAD staining. The expressions of active proapoptotic protein Bax, antiapoptotic protein Bcl-2, cytochrome c and the percentage of cells containing cleaved caspase-3 in treated CLL cells was determined by flow cytometry and immunocytochemistry. Results. The TP meth-anolic extract decreased the viability of all tested human leukemia cells but it had no effect on the viability of PBMCs isolated from healthy subjects. The cytotoxic effect of TP was caused by its induction of CLL cells? apoptosis. TP disarranged the ratio of the expressions of proapoptotic Bax and antiapoptotic Bcl-2 protein in favor of Bax, consequently inducing apoptosis by cytochrome c mitochondrial release and activation of caspase-3 in treated CLL cells. Conclusion. The TP leaves methanolic induced selective apoptosis in CLL cells and it affected the expressions of key proteins involved in the regulation of programmed cell death.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP181010005Z
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2020
    detail.hit.zdb_id: 2169819-3
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  • 6
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    New gold pincer-type complexes induce caspase-dependent apoptosis in human cancer cells in vitro
    National Library of Serbia ; 2021
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 78, No. 8 ( 2021), p. 865-873
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 78, No. 8 ( 2021), p. 865-873
    Abstract: Background/Aim. The use of cisplatin as a chemotherapeutic opened the door to the new metal-based drug research. New complexes containing metals such as platinum, palladium, ruthenium and gold have recently been analyzed as potential antitumor agents. The aim of the study was to investigate the cytotoxicity of Au(III) complexes with pincer-type ligands against cervical carcinoma cells (HeLa), breast cancer cells (MDA-MB-231 and 4T1) and colon carcinoma cells (HCT116 and CT26), as well as to examine the type and mechanism of cell death that these complexes induced in cancer cells. Methods. The cytotoxicity of Au(III) complexes was investigated by MTT assay. The apoptosis of the treated cancer cells was measured by flow cytometry and applying Annexin V/7AAD staining. The expressions of active proapoptotic protein Bax, antiapoptotic protein Bcl-2 and the percentage of cells containing cleaved caspase-3 in the treated cancer cells were determined by flow cytometry. Results. Complex 1 showed the most potent antitumor effect on HeLa cells, both compared to other two examined gold complexes and compared to cisplatin. The IC50 values on HeLa cells after 72 hours were 1.3 ? 0.4 ?M, 3.4 ? 1.3 ?M, 5.7 ? 0.6 ?M, 26.7 ? 6.5 ?M for complexes 1, 2, 3 and cisplatin, respectively. Complex 1 also exhibited the highest cytotoxicity against MDA-MB-231 and HCT116 cells compared to other tested compounds. The results of Annexin V/7AAD staining showed that all three gold complexes induced apoptosis in the treated cells. Our Au(III) complexes induced apoptosis by caspase-dependent mechanism, but we did not observe that the activation of an internal pathway of apoptosis occurred in the treated cancer cells. Conclusion. According to the results of our in vitro study, all three gold compounds, and especially complex 1, are promising candidates for a new generation of anticancer drugs.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP190507002Z
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2021
    detail.hit.zdb_id: 2169819-3
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  • 7
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    MANAGEMENT OF CLINICALLY CURED TONSILLOPHARYNGITIS IN PATIENTS WITH GROUP A STREPTOCOCCUS ISOLATED FROM A PHARYNGEAL SWAB
    Medical Faculty, University in Nis ; 2015
    In:  Acta Medica Medianae Vol. 54, No. 4 ( 2015-12-15), p. 46-51
    Details
    In: Acta Medica Medianae, Medical Faculty, University in Nis, Vol. 54, No. 4 ( 2015-12-15), p. 46-51
    Type of Medium: Online Resource
    ISSN: 0365-4478 , 1821-2794
    URL: Article
    DOI: 10.5633/amm.2015.0407
    Language: Unknown
    Publisher: Medical Faculty, University in Nis
    Publication Date: 2015
    detail.hit.zdb_id: 2583724-2
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  • 8
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    Validation of the fear of COVID-19 scale in a central Balkan country - Serbia
    Frontiers Media SA ; 2022
    In:  Frontiers in Public Health Vol. 10 ( 2022-8-23)
    Details
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 10 ( 2022-8-23)
    Abstract: High levels of fear of COVID-19 may be associated with increased levels of stress, anxiety, and depression, as well as decreased resilience and life expectancy. Objective This study aimed to translate and confirm the Serbian version of the Fear of COVID-19 scale as well as to investigate its psychometric properties. Methods The translation and intercultural adaptation of the Fear of COVID-19 scale was performed by the leading standard of the International Society for Pharmacoeconomics and Outcome Research. When the distribution was normal, the Kolmogorov-Smirnov test was used. The reliability of the Serbian version of FCV-19S was tested by measuring the internal consistency through the value of Cronbach's alpha. Results The original version of the Fear of COVID-19 scale was tested on a sample of 256 subjects with a mean age of 25.38 ± 12.47. The Cronbach's alpha value was 0.864. We divided the scale by the split-half method (Spearman-Brown), and the value of the coefficient for the questionnaire as a whole was 0.882. Divergent criterion validity was tested through the non-parametric correlation between the scores of the Fear of COVID-19 scale and the Fear of Hospitalization scale. A score of the Fear of COVID-19 scale was calculated as the sum of each question for each of the respondents. Convergent criterion validity was tested through the non-parametric correlation between the scores of the Fear of COVID-19 scale and the Emotional Regulation Questionnaire. Conclusion The validated version of the scale in Serbia complements versions available in other cultures and other languages and facilitates global studies related to mental health during the COVID-19 pandemic.
    Type of Medium: Online Resource
    ISSN: 2296-2565
    URL: Article
    DOI: 10.3389/fpubh.2022.972668
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2711781-9
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  • 9
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    Ligustrum vulgare leaves and fruit extracts induce apoptosis of human leukemia cells
    Hrvatski Prirodoslovno Drustvo (Croatian Society for Natural Sciences) ; 2022
    In:  Periodicum Biologorum Vol. 123, No. 3-4 ( 2022-07-01), p. 71-77
    Details
    In: Periodicum Biologorum, Hrvatski Prirodoslovno Drustvo (Croatian Society for Natural Sciences), Vol. 123, No. 3-4 ( 2022-07-01), p. 71-77
    Abstract: Background and purpose: Cytotoxic effects of Ligustrum vulgare leaves on HeLa cervical tumor cells suggested that Ligustrum vulgare extracts should be investigated as potential anticancer agents. Therefore, we examined a potential antileukemic activity of methanolic extracts of Ligustrum vulgare leaves and fruit extracts on two types of leukemia cells, MOLT-4 and JVM-13, lymphocytes isolated from the blood of 33 chronic lymphocytic leukemia (CLL) patients and on mononuclear leukocytes isolated from the blood of 18 healthy individuals.Material and methods: The cytotoxicity of examined extracts was measured by MTT assay and LDH activity test. The antiapoptotic potential of tested extracts was measured by Annexin V/7AAD flowcytometric assay.Results: The results showed that both extracts exhibited a moderate cytotoxic effect on all three types of leukemia cells. The Ligustrum vulgare leaf extract was the most effective on MOLT-4 cells, the fruit extract on JVM-13 cells and both extracts were equally effective on CLL cells. In addition, none of the tested extracts was toxic to healthy mononuclear cells. Both extracts acted by inducing apoptosis of leukemic cells.Conclusion: Ligustrum vulgare extracts exhibit significant antileukemic potential and should be further investigated.
    Type of Medium: Online Resource
    ISSN: 1849-0964 , 0031-5362
    URL: Article
    DOI: 10.18054/pb.v123i3-4.19206
    Language: Unknown
    Publisher: Hrvatski Prirodoslovno Drustvo (Croatian Society for Natural Sciences)
    Publication Date: 2022
    detail.hit.zdb_id: 2493383-1
    SSG: 12
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  • 10
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    Psychometric Properties of the Quality of Life Questionnaire - Cervical Cancer 24 (QLQ CX 24) Translation to Serbian
    Walter de Gruyter GmbH ; 2021
    In:  Serbian Journal of Experimental and Clinical Research Vol. 0, No. 0 ( 2021-03-13)
    Details
    In: Serbian Journal of Experimental and Clinical Research, Walter de Gruyter GmbH, Vol. 0, No. 0 ( 2021-03-13)
    Abstract: Introduction: Cancer of the cervix has a progressive character and is one of the most significant public health problems in many countries. Our research aimed to translate EORTC QLQ CX 24 (European Organization for Research and Treatment of Cancer; Quality of life questionnaire-cervical cancer 24) from English to Serbian, to create essential cultural adaptations and to analyze psychometric properties of the translation in a model of female inpatients with cancer of the cervix. Method: The QLQ CX 24 was translated and adapted according to internationally established guidelines, and then tested on a sample of 100 Serbian females with cancer of the cervix. The testing was repeated three times on the same patients. We calculated the internal consistency (Cronbach’s alpha), criterion validity, convergent validity, and discriminative validity of the QLQ CX 24. We used factor analysis to discover the original construct. Results: The Serbian translation of QLQ CX 24 showed good internal consistency, showed satisfactory reliability, and temporal stability. In the first, when was rated by the investigators Cronbach’s alpha was 0.607, and one month later when the questionnaire also was rated by investigators Cronbach’s alpha was 0.696. When the scale was rated by females themselves Cronbach’s alpha was 0.802. Divergent as well as convergent validity tests had good results. The factorial analysis exposed six domains.Conclusion: The Serbian translation of QLQ CX 24 is a trustworthy and appropriate specific instrument for measuring the quality of life in females with cervical cancer.
    Type of Medium: Online Resource
    ISSN: 2335-075X , 1820-8665
    URL: Article
    DOI: 10.2478/sjecr-2020-0047
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2021
    detail.hit.zdb_id: 2710266-X
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