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  • 1
    Online Resource
    Online Resource
    Monocytes and Macrophages Serve as Potent Prostaglandin D2 Sources during Acute, Non-Allergic Pulmonary Inflammation
    MDPI AG ; 2021
    In:  International Journal of Molecular Sciences Vol. 22, No. 21 ( 2021-10-28), p. 11697-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 22, No. 21 ( 2021-10-28), p. 11697-
    Abstract: Acute respiratory inflammation, most commonly resulting from bacterial or viral infection, is one of the leading causes of death and disability worldwide. The inflammatory lipid mediator prostaglandin D2 (PGD2) and its rate-limiting enzyme, hematopoietic PGD synthase (hPGDS), are well-known drivers of allergic pulmonary inflammation. Here, we sought to investigate the source and role of hPGDS-derived PGD2 in acute pulmonary inflammation. Murine bronchoalveolar monocytes/macrophages from LPS- but not OVA-induced lung inflammation released significant amounts of PGD2. Accordingly, human monocyte-derived macrophages expressed high basal levels of hPGDS and released significant levels of PGD2 after LPS/IFN-γ, but not IL-4 stimulation. Human peripheral blood monocytes secreted significantly more PGD2 than monocyte-derived macrophages. Using human precision-cut lung slices (PCLS), we observed that LPS/IFN-γ but not IL-4/IL-13 drive PGD2 production in the lung. HPGDS inhibition prevented LPS-induced PGD2 release by human monocyte-derived macrophages and PCLS. As a result of hPGDS inhibition, less TNF-α, IL-6 and IL-10 could be determined in PCLS-conditioned medium. Collectively, this dataset reflects the time-dependent release of PGD2 by human phagocytes, highlights the importance of monocytes and macrophages as PGD2 sources and suggests that hPGDS inhibition might be a potential therapeutic option for acute, non-allergic lung inflammation.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms222111697
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Encapsulation of Bilberry Extract with Maltodextrin and Gum Arabic by Freeze-Drying: Formulation, Characterisation, and Storage Stability
    MDPI AG ; 2022
    In:  Processes Vol. 10, No. 10 ( 2022-10-02), p. 1991-
    Details
    In: Processes, MDPI AG, Vol. 10, No. 10 ( 2022-10-02), p. 1991-
    Abstract: Anthocyanins are polyphenolic plant pigments associated with antioxidant and health-promoting properties. However, their application in the food industry is limited due to their poor stability. The purpose of this study was to encapsulate anthocyanin-rich bilberry (Vaccinium myrtillus L.) extract by freeze-drying and to investigate the effects of different wall materials and extract contents on the physicochemical and bioactive properties of the obtained encapsulates. Ethanolic bilberry extract was encapsulated with the use of maltodextrin (16.5–19.5 DE) (MD), gum Arabic (GA), and their combination in a 1:1 w/w ratio (MIX). Bilberry solids to wall material ratios were examined at 20:80, 30:70, and 40:60. All encapsulates showed an attractive red colour and low water activity values (aw ≤ 0.3) that indicated a low risk of microbial spoilage. In general, the biggest losses of total phenolic compounds and anthocyanins during three-week storage in the dark and at room temperature (20 ± 2 °C) were detected in the case of encapsulates with a higher content of bilberry extract (MIX30 and MIX40, and GA30 and GA40, respectively). The use of maltodextrin provided the best protection to bilberry anthocyanins during forced storage. Overall, the obtained encapsulates show suitable potential for the development of food products with added nutritional benefits.
    Type of Medium: Online Resource
    ISSN: 2227-9717
    URL: Article
    DOI: 10.3390/pr10101991
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2720994-5
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  • 3
    Online Resource
    Online Resource
    Basic Methods for Preparation of Liposomes and Studying Their Interactions with Different Compounds, with the Emphasis on Polyphenols
    MDPI AG ; 2021
    In:  International Journal of Molecular Sciences Vol. 22, No. 12 ( 2021-06-18), p. 6547-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 22, No. 12 ( 2021-06-18), p. 6547-
    Abstract: Studying the interactions between lipid membranes and various bioactive molecules (e.g., polyphenols) is important for determining the effects they can have on the functionality of lipid bilayers. This knowledge allows us to use the chosen compounds as potential inhibitors of bacterial and cancer cells, for elimination of viruses, or simply for keeping our healthy cells in good condition. As studying those effect can be exceedingly difficult on living cells, model lipid membranes, such as liposomes, can be used instead. Liposomal bilayer systems represent the most basic platform for studying those interactions, as they are simple, quite easy to prepare and relatively stable. They are especially useful for investigating the effects of bioactive compounds on the structure and kinetics of simple lipid membranes. In this review, we have described the most basic methods available for preparation of liposomes, as well as the essential techniques for studying the effects of bioactive compounds on those liposomes. Additionally, we have provided details for an easy laboratory implementation of some of the described methods, which should prove useful especially to those relatively new on this research field.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms22126547
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2019364-6
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  • 4
    Online Resource
    Online Resource
    Evolutionary Rates in the Haptophyta: Exploring Molecular and Phenotypic Diversity
    MDPI AG ; 2022
    In:  Journal of Marine Science and Engineering Vol. 10, No. 6 ( 2022-06-09), p. 798-
    Details
    In: Journal of Marine Science and Engineering, MDPI AG, Vol. 10, No. 6 ( 2022-06-09), p. 798-
    Abstract: Haptophytes are photosynthetic protists found in both freshwater and marine environments with an origin possibly dating back to the Neoproterozoic era. The most recent molecular phylogeny reveals several haptophyte “mystery clades” that await morphological verification, but it is otherwise highly consistent with morphology-based phylogenies, including that of the coccolithophores (calcifying haptophytes). The fossil coccolith record offers unique insights into extinct lineages, including the adaptive radiations that produced extant descendant species. By combining molecular data of extant coccolithophores and phenotype-based studies of their ancestral lineages, it has become possible to probe the modes and rates of speciation in more detail, although this approach is still limited to only few taxa because of the lack of whole-genome datasets. The evolution of calcification likely involved several steps, but its origin can be traced back to an early association with organic scales typical for all haptophytes. Other key haptophyte traits, including the haplo-diplontic life cycle, are herein mapped upon the coccolithophorid phylogeny to help navigate a discussion of their ecological benefits and trade-offs in a rapidly changing ocean.
    Type of Medium: Online Resource
    ISSN: 2077-1312
    URL: Article
    DOI: 10.3390/jmse10060798
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2738390-8
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  • 5
    Online Resource
    Online Resource
    Contribution to the knowledge of the butterfly fauna (Lepidoptera: Papilionoidea) of Central Slovenia
    University of Ljubljana ; 2023
    In:  Natura Sloveniae Vol. 25, No. 1 ( 2023-08-11), p. 5-25
    Details
    In: Natura Sloveniae, University of Ljubljana, Vol. 25, No. 1 ( 2023-08-11), p. 5-25
    Abstract: The southwestern Posavsko hills and northern Suha krajina are among the least studied areas regarding the butterfly fauna in Slovenia. To fill this knowledge gap, we selected all unpublished records of butterflies since 2014, in addition to the focused field surveys performed in the 2019–2022 period. We recorded a total of 105 butterfly species, presenting almost 60% of all species found in Slovenia. Among the species found, there are several habitat specialists of high conservation importance, e.g., Leptidea morsei, Euphydryas aurinia, Parnassius mnemosyne, Phengaris arion, Carcharodus floccifera, Lycaena dispar. Locations harbouring these species and those with the highest species richness are of great importance for preserving the diverse butterfly fauna of the region.
    Type of Medium: Online Resource
    ISSN: 1854-3081 , 1580-0814
    URL: Issue
    URL: Article
    DOI: 10.14720/ns.25.1
    DOI: 10.14720/ns.25.1.5-25
    Language: Unknown
    Publisher: University of Ljubljana
    Publication Date: 2023
    detail.hit.zdb_id: 2451116-X
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Interactions of (−)-epigallocatechin-3-gallate with model lipid membranes
    Elsevier BV ; 2022
    In:  Biochimica et Biophysica Acta (BBA) - Biomembranes Vol. 1864, No. 10 ( 2022-10), p. 183999-
    Details
    In: Biochimica et Biophysica Acta (BBA) - Biomembranes, Elsevier BV, Vol. 1864, No. 10 ( 2022-10), p. 183999-
    Type of Medium: Online Resource
    ISSN: 0005-2736
    URL: Article
    DOI: 10.1016/j.bbamem.2022.183999
    RVK:
    WA 15000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2209384-9
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Advances in the Propolis Chemical Composition between 2013 and 2018: A Review
    Wiley ; 2020
    In:  eFood Vol. 1, No. 1 ( 2020-02), p. 24-37
    Details
    In: eFood, Wiley, Vol. 1, No. 1 ( 2020-02), p. 24-37
    Abstract: Propolis is a lipophilic sticky substance collected by bees that has been used by humans for centuries. Owing to its healing, antioxidant, and other medicinal properties, its chemical composition has been widely studied. Most pharmacological properties of propolis have been attributed to its phenols and terpenes, mainly flavonoids, phenolic acids, and their derivatives. More than 500 components of propolis were known from different parts of the world until 2012. In this article, 305 new constituents of propolis described between 2013 and 2018 are being reviewed, with 19 additional compounds that were discovered between 2011 and 2012, and were excluded from a similar previous review article. Altogether more than 850 compounds were isolated from propolis until 2018.
    Type of Medium: Online Resource
    ISSN: 2666-3066 , 2666-3066
    URL: Article
    DOI: 10.2991/efood.k.191029.001
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 3052331-X
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  • 8
    Online Resource
    Online Resource
    Effects of Hydrophobic Gold Nanoparticles on Structure and Fluidity of SOPC Lipid Membranes
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 12 ( 2023-06-16), p. 10226-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 12 ( 2023-06-16), p. 10226-
    Abstract: Gold nanoparticles (AuNPs) are promising candidates in various biomedical applications such as sensors, imaging, and cancer therapy. Understanding the influence of AuNPs on lipid membranes is important to assure their safety in the biological environment and to improve their scope in nanomedicine. In this regard, the present study aimed to analyze the effects of different concentrations (0.5, 1, and 2 wt.%) of dodecanethiol functionalized hydrophobic AuNPs on the structure and fluidity of zwitterionic 1-stearoyl-2-oleoyl-sn-glycerol-3-phosphocholine (SOPC) lipid bilayer membranes using Fourier-transform infrared (FTIR) spectroscopy and fluorescent spectroscopy. The size of AuNPs was found to be 2.2 ± 1.1 nm using transmission electron microscopy. FTIR results have shown that the AuNPs induced a slight shift in methylene stretching bands, while the band positions of carbonyl and phosphate group stretching were unaffected. Temperature-dependent fluorescent anisotropy measurements showed that the incorporation of AuNPs up to 2 wt.% did not affect the lipid order in membranes. Overall, these results indicate that the hydrophobic AuNPs in the studied concentration did not cause any significant alterations in the structure and membrane fluidity, which suggests the suitability of these particles to form liposome–AuNP hybrids for diverse biomedical applications including drug delivery and therapy.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms241210226
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Stabilisation of Ce-Cu-Fe amorphous alloys by addition of Al
    Informa UK Limited ; 2016
    In:  Philosophical Magazine Vol. 96, No. 30 ( 2016-10-22), p. 3143-3158
    Details
    In: Philosophical Magazine, Informa UK Limited, Vol. 96, No. 30 ( 2016-10-22), p. 3143-3158
    Type of Medium: Online Resource
    ISSN: 1478-6435 , 1478-6443
    URL: Article
    DOI: 10.1080/14786435.2016.1229062
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2016
    detail.hit.zdb_id: 3058388-3
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  • 10
    Online Resource
    Online Resource
    Butterflies (Lepidoptera: Papilionoidea) of northwestern and western Crete (Greece) in early July, with the finding of new larval host plant for Lampides boeticus : Surveying the distribution of diurnal butterflies of western Crete
    National Documentation Centre (EKT) ; 2022
    In:  ENTOMOLOGIA HELLENICA Vol. 31, No. 2 ( 2022-11-02), p. 50-60
    Details
    In: ENTOMOLOGIA HELLENICA, National Documentation Centre (EKT), Vol. 31, No. 2 ( 2022-11-02), p. 50-60
    Abstract: During the summer of 2021 northwestern and western areas of the Greek island of Crete were surveyed, in order to confirm certain observations of the diurnal butterfly fauna of the island. Research was focused especially on the unsurveyed north-western parts of the island, as well as surveying the species that are extending their areal (Cacyreus marshalli (Butler), Lampides boeticus (L.)). From 47 species reported from the island, 23 were observed. The surveys were all carried out during an especially hot and dry weather period (30-37 °C), between 30th of June and 6th of July. Additionally, a new larval host plant for L. boeticus was confirmed, as oviposition of females on Campsis radicans (Seem.) was observed on several occasions.
    Type of Medium: Online Resource
    ISSN: 2459-3885 , 0254-5381
    URL: Article
    DOI: 10.12681/eh.29961
    Language: Unknown
    Publisher: National Documentation Centre (EKT)
    Publication Date: 2022
    detail.hit.zdb_id: 2644216-4
    SSG: 12
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