In:
Acta Veterinaria Brno, University of Veterinary Sciences Brno, Vol. 86, No. 4 ( 2017), p. 399-404
Abstract:
The objective of this study was to investigate the effect of the probiotic strain Lactobacillus plantarum LS/07 and prebiotic inulin on the activity of β-glucuronidase, transcription nuclear factor kappa B (NFκB), myeloperoxidase (MPO), cytokine levels (IL-6, IL-8, IL-13), and counts of coliforms and lactobacilli in rats with dextran sulphate sodium (DSS) induced acute colitis. Sprague-Dawley rats were divided into groups: control (C), acute colitis (AC), prebiotic (Pre), and probiotic (Pro). Dextran sulphate sodium induced inflammatory process in the colonic tissue, increased the activity of β-glucuronidase ( P 〈 0.05), increased counts of coliforms, decreased lactobacilli counts ( P 〈 0.05), and activated production of the measured indicators NFκB, MPO, IL-6, IL-8, except of IL-13. Diet supplemented with L. plantarum and inulin alleviated DSS induced inflammatory process by inhibiting production of IL-6, IL-8, activities of NFκB and MPO, and by stimulation of IL-13. These results indicate that the dietary intake of Lactobacillus plantarum LS/07 and inulin suppressed the expression of markers playing an important role in the inflammatory process, which predisposes their use in prevention or treatment of acute colitis.
Type of Medium:
Online Resource
ISSN:
0001-7213
,
1801-7576
DOI:
10.2754/avb201786040399
Language:
English
Publisher:
University of Veterinary Sciences Brno
Publication Date:
2017
detail.hit.zdb_id:
2106644-9
detail.hit.zdb_id:
40121-3
SSG:
22
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