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  • 1
    Online Resource
    Online Resource
    Circadian Typology and Personality Dimensions of Croatian Students of Health-Related University Majors
    MDPI AG ; 2020
    In:  International Journal of Environmental Research and Public Health Vol. 17, No. 13 ( 2020-07-03), p. 4794-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 17, No. 13 ( 2020-07-03), p. 4794-
    Abstract: The aim of this study was to determine the relationship between circadian preferences and personality dimensions among 712 students of three different majors from the Faculty of Medicine, Osijek: medical students (MD), nursing students (RN) and medical laboratory diagnostics students (MLD). For the measurement of personality dimensions, the IPIP50 Big-Five questionnaire was used. The circadian preference of students was assessed using the reduced morningness-eveningness questionnaire (rMEQ). Several significant results were observed and there was a significant difference in circadian preference among the three tested groups, with RN students scoring highest on the morningness scale and MLD students scoring the lowest. RN students scored significantly higher on agreeableness and conscientiousness than the other two groups. On the other hand, MD students scored higher on intellect than the MLD students. MLD students scored the lowest on emotional stability scales. Morning type students had higher conscientiousness and emotional stability scores. These results imply that circadian preference and personality traits are crucial elements of medical professionals’ wellbeing. With this paper, we would like to raise awareness about common personality traits and adherence to certain circadian orientations in medical professionals as a motivation to introduce a more flexible view towards strict time and task divisions in everyday practice.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph17134794
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2175195-X
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  • 2
    Online Resource
    Online Resource
    Genetic variations in circadian rhythm genes and susceptibility for myocardial infarction
    FapUNIFESP (SciELO) ; 2018
    In:  Genetics and Molecular Biology Vol. 41, No. 2 ( 2018-05-14), p. 403-409
    Details
    In: Genetics and Molecular Biology, FapUNIFESP (SciELO), Vol. 41, No. 2 ( 2018-05-14), p. 403-409
    Type of Medium: Online Resource
    ISSN: 1678-4685 , 1415-4757
    URL: Article
    DOI: 10.1590/1678-4685-gmb-2017-0147
    Language: Unknown
    Publisher: FapUNIFESP (SciELO)
    Publication Date: 2018
    detail.hit.zdb_id: 2126947-6
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    The Association between Circadian Clock Gene Polymorphisms and Metabolic Syndrome: A Systematic Review and Meta-Analysis
    MDPI AG ; 2021
    In:  Biology Vol. 11, No. 1 ( 2021-12-24), p. 20-
    Details
    In: Biology, MDPI AG, Vol. 11, No. 1 ( 2021-12-24), p. 20-
    Abstract: Metabolic syndrome (MetS) is a combination of cardiovascular risk factors associated with type 2 diabetes, obesity, and cardiovascular diseases. The circadian clock gene polymorphisms are very likely to participate in metabolic syndrome genesis and development. However, research findings of the association between circadian rhythm gene polymorphisms and MetS and its comorbidities are not consistent. In this study, a review of the association of circadian clock gene polymorphisms with overall MetS risk was performed. In addition, a meta-analysis was performed to clarify the association between circadian clock gene polymorphisms and MetS susceptibility based on available data. The PubMed and Scopus databases were searched for studies reporting the association between circadian rhythm gene polymorphisms (ARNTL, BMAL1, CLOCK, CRY, PER, NPAS2, REV-ERBα, REV-ERBβ, and RORα) and MetS, and its comorbidities diabetes, obesity, and hypertension. Thirteen independent studies were analyzed with 17,381 subjects in total. The results revealed that the BMAL1 rs7950226 polymorphism was associated with an increased risk of MetS in the overall population. In contrast, the CLOCK rs1801260 and rs6850524 polymorphisms were not associated with MetS. This study suggests that some circadian rhythm gene polymorphisms might be associated with MetS in different populations and potentially used as predictive biomarkers for MetS.
    Type of Medium: Online Resource
    ISSN: 2079-7737
    URL: Article
    DOI: 10.3390/biology11010020
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2661517-4
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  • 4
    Online Resource
    Online Resource
    Legionella pneumophila—Virulence Factors and the Possibility of Infection in Dental Practice
    MDPI AG ; 2022
    In:  Microorganisms Vol. 10, No. 2 ( 2022-01-24), p. 255-
    Details
    In: Microorganisms, MDPI AG, Vol. 10, No. 2 ( 2022-01-24), p. 255-
    Abstract: Legionella pneumophila is defined as a bacterium that can cause severe pneumonia. It is found in the natural environment and in water, and is often found in water tanks. It can be an integral part of biofilms in nature, and the protozoa in which it can live provide it with food and protect it from harmful influences; therefore, it has the ability to move into a sustainable but uncultured state (VBNC). L. pneumophila has been shown to cause infections in dental practices. The most common transmission route is aerosol generated in dental office water systems, which can negatively affect patients and healthcare professionals. The most common way of becoming infected with L. pneumophila in a dental office is through water from dental instruments, and the dental unit. In addition to these bacteria, patients and the dental team may be exposed to other harmful bacteria and viruses. Therefore, it is vital that the dental team regularly maintains and decontaminates the dental unit, and sterilizes all accessories that come with it. In addition, regular water control in dental offices is necessary.
    Type of Medium: Online Resource
    ISSN: 2076-2607
    URL: Article
    DOI: 10.3390/microorganisms10020255
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2720891-6
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  • 5
    Online Resource
    Online Resource
    Homeostasis and Dysbiosis of the Intestinal Microbiota: Comparing Hallmarks of a Healthy State with Changes in Inflammatory Bowel Disease
    MDPI AG ; 2022
    In:  Microorganisms Vol. 10, No. 12 ( 2022-12-05), p. 2405-
    Details
    In: Microorganisms, MDPI AG, Vol. 10, No. 12 ( 2022-12-05), p. 2405-
    Abstract: The gut microbiota, which represent a community of different microorganisms in the human intestinal tract, are crucial to preserving human health by participating in various physiological functions and acting as a metabolic organ. In physiological conditions, microbiota–host partnership exerts homeostatic stability; however, changes in intestinal microbiota composition (dysbiosis) are an important factor in the pathogenesis of inflammatory bowel disease and its two main disease entities: ulcerative colitis and Crohn’s disease. The incidence and prevalence of these inflammatory conditions have increased rapidly in the last decade, becoming a significant problem for the healthcare system and a true challenge in finding novel therapeutic solutions. The issue is that, despite numerous studies, the etiopathogenesis of inflammatory bowel disease is not completely clear. Based on current knowledge, chronic intestinal inflammation occurs due to altered intestinal microbiota and environmental factors, as well as a complex interplay between the genetic predisposition of the host and an inappropriate innate and acquired immune response. It is important to note that the development of biological and immunomodulatory therapy has led to significant progress in treating inflammatory bowel disease. Certain lifestyle changes and novel approaches—including fecal microbiota transplantation and nutritional supplementation with probiotics, prebiotics, and synbiotics—have offered solutions for dysbiosis management and paved the way towards restoring a healthy microbiome, with only minimal long-term unfavorable effects.
    Type of Medium: Online Resource
    ISSN: 2076-2607
    URL: Article
    DOI: 10.3390/microorganisms10122405
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2720891-6
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  • 6
    Online Resource
    Online Resource
    The Association of ABO and RhD Blood Groups with COVID-19 Mortality of Patients Hospitalized in the COVID Ward at General Hospital Karlovac
    University of Rijeka, Faculty of Medicine ; 2023
    In:  Medicina Fluminensis Vol. 59, No. 2 ( 2023-06-01), p. 161-169
    Details
    In: Medicina Fluminensis, University of Rijeka, Faculty of Medicine, Vol. 59, No. 2 ( 2023-06-01), p. 161-169
    Abstract: Aim: This study aimed to examine the association of ABO and RhD blood groups with COVID-19 mortality of patients hospitalized in the COVID ward at General Hospital Karlovac. Participants and methods: The study included data about 778 patients with COVID-19 hospitalized in the COVID ward at General Hospital Karlovac from March 2020 to the end of December 2021. Data about the hospitalized patients’ age, sex, blood groups, RhD status, comorbidities, oxygen, respirator use, vaccination, and disease course and outcome were obtained from the Hospital Management System. Furthermore, the association of ABO and RhD blood groups with the number of days in the hospital and the mortality rate was examined. Results: The prevalent blood group was O, with 283 patients (36.4%), while the A blood group was the second most common (35.8%). The least common blood group was AB (7.6%). At the time of hospitalization, a small number of patients had been vaccinated, only 8.1%. The overall COVID-19-associated mortality of 25.9% was observed. The mortality rate was 39.7% in blood group A, 24.2% in group B, 23.7% in group AB and 23.7% in group O (P = 0.588). The mortality rate from the COVID-19 disease was higher in RhD-positive (26.4%) compared to RhD-negative individuals (23.7%). The largest number of patients on a respirator (16.5%) were A blood group. Conclusion: The study did not find a significant association between the ABO and RhD blood group and the COVID-19 severity and mortality among patients hospitalized in the COVID ward at General Hospital Karlovac.
    Type of Medium: Online Resource
    ISSN: 1848-820X , 1847-6864
    URL: Journal
    URL: Article
    DOI: 10.21860/1848-820X
    DOI: 10.21860/medflum2023_300574
    Language: Unknown
    Publisher: University of Rijeka, Faculty of Medicine
    Publication Date: 2023
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  • 7
    Online Resource
    Online Resource
    A CROSS-SECTIONAL STUDY OF PSYCHIATRIC COMORBIDITY IN CROATIAN HOMELAND WAR VETERANS WHO WERE HELD AS PRISONERS OF WAR AND ARE AFFEC
    Medicinska Naklada d.o.o. ; 2022
    In:  PSYCHIATRIA DANUBINA Vol. 34, No. 3 ( 2022-10-17), p. 464-474
    Details
    In: PSYCHIATRIA DANUBINA, Medicinska Naklada d.o.o., Vol. 34, No. 3 ( 2022-10-17), p. 464-474
    Type of Medium: Online Resource
    ISSN: 0353-5053
    Uniform Title: A CROSS-SECTIONAL STUDY OF PSYCHIATRIC COMORBIDITY IN CROATIAN HOMELAND WAR VETERANS WHO WERE HELD AS PRISONERS OF WAR AND ARE AFFEC
    URL: Journal
    URL: Article
    DOI: 10.24869/psyd.
    DOI: 10.24869/psyd.2022.464
    RVK:
    XA 10000
    Language: Unknown
    Publisher: Medicinska Naklada d.o.o.
    Publication Date: 2022
    detail.hit.zdb_id: 2502383-4
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  • 8
    Online Resource
    Online Resource
    Circadian clock genes and myocardial infarction in patients with type 2 diabetes mellitus
    Elsevier BV ; 2019
    In:  Gene Vol. 701 ( 2019-06), p. 98-103
    Details
    In: Gene, Elsevier BV, Vol. 701 ( 2019-06), p. 98-103
    Type of Medium: Online Resource
    ISSN: 0378-1119
    URL: Article
    DOI: 10.1016/j.gene.2019.03.038
    RVK:
    WA 15000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 1491012-3
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    The Relationship between Sleep, Chronotype, and Dental Caries—A Narrative Review
    MDPI AG ; 2023
    In:  Clocks & Sleep Vol. 5, No. 2 ( 2023-05-15), p. 295-312
    Details
    In: Clocks & Sleep, MDPI AG, Vol. 5, No. 2 ( 2023-05-15), p. 295-312
    Abstract: This article provides an overview of how sleep and circadian rhythm disturbances mutually influence the occurrence of dental caries and how it is possible to reduce the risk of circadian rhythm disturbances, sleep, and associated adverse effects. Dental caries is a global problem worldwide that contributes to sociological limitations. Numerous factors influence the occurrence of dental caries, from socioeconomic factors to cariogenic bacteria, dietary habits, and oral hygiene. However, sleep disorders and circadian rhythm disturbances represent a new approach in the fight against the increasing prevalence of dental caries worldwide. Bacteria in the oral cavity and the oral microbiome are mainly responsible for the development of caries, and saliva plays an important role in their regulation. The circadian rhythm regulates numerous physiological functions, including sleep and saliva production. Disturbances in sleep and circadian rhythms affect saliva production, which impacts the development of dental caries, as saliva is necessary for regulating and maintaining oral health, especially for controlling oral infections. A person’s preference for a particular time of day depends on the circadian rhythm called chronotype. Individuals with an evening chronotype have a less healthy lifestyle that can lead to a higher caries risk than individuals with a morning chronotype. Because circadian rhythms are critical to maintaining sleep homeostasis and oral health, sleep disturbances can disrupt circadian rhythms and lead to a vicious cycle.
    Type of Medium: Online Resource
    ISSN: 2624-5175
    URL: Article
    DOI: 10.3390/clockssleep5020023
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2966788-4
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  • 10
    Online Resource
    Online Resource
    Hereditary hemochromatosis gene mutations in patients with myocardial infarction
    Croatian Society of Biologists in Health Care ; 2019
    In:  Molecular and experimental biology in medicine Vol. 2, No. 1 ( 2019-04-04), p. 24-28
    Details
    In: Molecular and experimental biology in medicine, Croatian Society of Biologists in Health Care, Vol. 2, No. 1 ( 2019-04-04), p. 24-28
    Abstract: Hereditary hemochromatosis (HH) is a disorder of iron accumulation in tissues, which is related to coronary heart diseases. Free radicals and reactive oxygen species, created because of iron deposition, promote oxidation of LDL cholesterol and could lead to the development of atherosclerosis. Studies have shown that HFE gene mutation carriers might be at higher risk of developing cardiovascular diseases compared with non-carriers. This study aimed to determine the frequency of HFE gene mutations in patients with myocardial infarction compared to a healthy group in eastern Slavonia. A retrospective case-control study was carried out on a population of 400 participants. In the first group there were 200 patients (114 males and 86 females) with myocardial infarction. The second group consisted of 200 controls (103 males and 97 females) without a history of cardiovascular diseases. All patients were genotyped for the three most common mutations of the HH in the HFE gene: C282Y, H63D, and S65C, by real-time PCR. The difference in the frequency of carriers of these mutations between the patients and the controls was not significant (C282Y: 4.5 vs. 8.1%; H63D: 19 vs. 24.5%; S65C: 3.5 versus 4%), and neither was the frequency and distribution of possible HFE gene genotypes and compound heterozygotes. There were no statistically significant associations of cardiovascular risk factors and HFE gene mutations in patients with myocardial infarction. In this study, no association was found between the HFE gene mutation for HH and myocardial infarction in the population of eastern Slavonia.
    Type of Medium: Online Resource
    ISSN: 2584-671X
    URL: Journal
    URL: Article
    DOI: 10.33602/mebm
    DOI: 10.33602/mebm.2.1.4
    Language: Unknown
    Publisher: Croatian Society of Biologists in Health Care
    Publication Date: 2019
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