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  • 1
    Online Resource
    Online Resource
    A new calibration method for charm jet identification validated with proton-proton collision events at √s = 13 TeV
    IOP Publishing ; 2022
    In:  Journal of Instrumentation Vol. 17, No. 03 ( 2022-03-01), p. P03014-
    Details
    In: Journal of Instrumentation, IOP Publishing, Vol. 17, No. 03 ( 2022-03-01), p. P03014-
    Abstract: Many measurements at the LHC require efficient identification of heavy-flavour jets, i.e. jets originating from bottom (b) or charm (c) quarks. An overview of the algorithms used to identify c jets is described and a novel method to calibrate them is presented. This new method adjusts the entire distributions of the outputs obtained when the algorithms are applied to jets of different flavours. It is based on an iterative approach exploiting three distinct control regions that are enriched with either b jets, c jets, or light-flavour and gluon jets. Results are presented in the form of correction factors evaluated using proton-proton collision data with an integrated luminosity of 41.5 fb -1 at  √s = 13 TeV, collected by the CMS experiment in 2017. The closure of the method is tested by applying the measured correction factors on simulated data sets and checking the agreement between the adjusted simulation and collision data. Furthermore, a validation is performed by testing the method on pseudodata, which emulate various mismodelling conditions. The calibrated results enable the use of the full distributions of heavy-flavour identification algorithm outputs, e.g. as inputs to machine-learning models. Thus, they are expected to increase the sensitivity of future physics analyses.
    Type of Medium: Online Resource
    ISSN: 1748-0221
    URL: Article
    DOI: 10.1088/1748-0221/17/03/P03014
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 2235672-1
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  • 2
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    Online Resource
    Alpha-1-Antitrypsin Deficiency – Molecular Basis, Clinical Presentation, Therapeutic Options and an Integrative Approach in Diagnostics / DEFICIJENCIJA ALFA-1-ANTITRIPSINA – MOLEKULSKE OSNOVE, KLINIČKE MANIFESTACIJE, TERAPIJSKE MOGUĆNOSTI I INTEGRATIVNI PRISTUP U DIJAGNOSTICI
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2014
    In:  Journal of Medical Biochemistry Vol. 33, No. 1 ( 2014-01-1), p. 88-96
    Details
    In: Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 33, No. 1 ( 2014-01-1), p. 88-96
    Abstract: The primary role of alpha-1-antitrypsin (AAT), encoded by the highly polymorphic SERPINA1 gene, is to protect the lung parenchyma from proteolysis by neutrophil elastase. AAT deficiency (AATD) is an autosomal recessive disease, considered as the most important genetic cause of liver disease in children and emphysema in adults. According to frequency, deficient alleles can be classified as »common« (Z and S) and »rare« (Mmalton, Mheerlen, Mprocida etc). Type, intensity and onset of clinical disease associated with AATD occur as a result of interaction between AATD and additional genetic and acquired factors (tobacco smoking, air pollution exposure etc). The most frequent clinical manifestations include premature emphysema, chronic hepatitis, cirrhosis and hepatocellular carcinoma. Epidemiological studies highlight the need for improvement in diagnostic efficiency for AATD. It is recommended for a diagnostic approach to integrate precise, internationally recognized clinical criteria and a standardized laboratory protocol, based on a combination of biochemical and molecular methods. The predilection site of cli nical manifestations guides the therapeutic approach. Augmen tation therapy is possible in lung disease, while currently the only specific measure in patients with severe liver failure due to AATD is transplantation. In all patients, preventive measures, ammeliorating the deleterious effects of habits and environmental factors are recommended. Introduction of gene therapy is expected to additionally improve health outcomes in affected persons. Current results with an integrative AATD diagnostic strategy in the Serbian population are highly encouraging, prompting towards its further implementation in common medical practice with the ultimate goal to establish a national register of affected individuals.
    Type of Medium: Online Resource
    ISSN: 1452-8266 , 1452-8258
    URL: Article
    DOI: 10.2478/jomb-2013-0038
    Language: Unknown
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2014
    detail.hit.zdb_id: 2405112-3
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  • 3
    Online Resource
    Online Resource
    Questionable Reliability Of Homocysteine As The Metabolic Marker For Folate And Vitamin B12 Deficiency In Patients With Chronic Obstructive Pulmonary Disease
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2015
    In:  Journal of Medical Biochemistry Vol. 34, No. 4 ( 2015-10-1), p. 467-472
    Details
    In: Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 34, No. 4 ( 2015-10-1), p. 467-472
    Abstract: Background: An increased homocysteine (Hcy) concentration may represent a metabolic marker of folate and vitamin B 12 deficiency, both significant public health problems. For different reasons, patients with chronic obstructive pulmonary disease (COPD) are prone to these deficiencies. The study evaluates the reliability of Hcy concentration in predicting folate or vitamin B 12 deficiency in these patients. Methods: A group of 50 COPD patients (28 males/22 females, age $({\rm{\bar x}} \pm {\rm{SD}} = 49.0 \pm 14.5)$ years was enrolled. A chemiluminescent microparticle immunoassay was applied for homocysteine, folate and vitamin B 12 concentration. Kolmogorov-Smirnov, Mann-Whitney U and χ 2 tests, Spearman’s correlation and ROC analysis were included in the statistical analysis, with the level of significance set at 0.05. Results: Average (SD) concentrations of folate and vitamin B 12 were 4.13 (2.16) μg/L and 463.6 (271.0) ng/L, whereas only vitamin B 12 correlated with the Hcy level (P=−0.310 (R=0.029)). Gender related differences were not significant and only a borderline significant correlation between age and folate was confirmed (R=0.279 (P=0.047)). The incidence of folate and vitamin B12 deficiency differed significantly (P=0.000 and P 〈 0.000 for folate and vitamin B 12 respectively), depending on the cut-off used for classification (4.4, 6.6 and 8.0 μg/L – folate; 203 and 473 ng/L – vitamin B 12 ). ROC analyses failed to show any significance of hyperhomocysteinemia as a predictor of folate or vitamin B 12 deficiency. Conclusion: Reliability of the Hcy concentration as a biomarker of folate or vitamin B 12 depletion in COPD patients is not satisfactory, so their deficiency cannot be predicted by the occurrence of HHcy.
    Type of Medium: Online Resource
    ISSN: 1452-8266
    URL: Article
    DOI: 10.2478/jomb-2014-0046
    Language: Unknown
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2015
    detail.hit.zdb_id: 2405112-3
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  • 4
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    Incidence of Hyperhomocysteinemia and Mthfr C677T Polymorphism Among Young Patients with Acute Myocardial Infarction
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2009
    In:  Journal of Medical Biochemistry Vol. 28, No. 1 ( 2009-01-1), p. 41-45
    Details
    In: Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 28, No. 1 ( 2009-01-1), p. 41-45
    Abstract: Hyperhomocysteinemia is considered an independent risk factor for premature cardiovascular disease. Mutation MTHFR C677T reduces the activity of methylenetetra-hydrofolatereductase and may cause hyperhomocysteinemia. Incidence of hyperhomocysteinemia (homocysteine above 12 μmol/L), homocysteine level, and distribution of MTHFR C677T genotypes (C/C, C/T and T/T) are compared between young patients with acute myocardial infarction and healthy persons, matched by age. Study involved 86 patients younger than 45 years (77 men and 9 women) and 35 controls. Homocysteine was measured by an HPLC method and the MTHFR C677T genotype determined using PCR amplification and digestion with Hinf I. Statistical analyses included chisquare and Mann-Whitney U tests. Hyperhomocysteinemia was present in 32.6% patients and 14.3% controls, revealing a significant difference (P= 0.038). Median homocysteine levels in patients (10.4 μmol/L) and controls (9.6 μmol/L) were significantly different (P=0.035). Among patients, 50.0% had C/C, 41.9% C/T and 8.1% T/T genotype, and the genotype had no influence on hyperhomocysteinemia incidence and homocysteine level. Genotype distribution in patients was not significantly different from that observed in controls. The conclusion is that young patients with acute myocardial infarction have higher incidence of hyperhomocysteinemia and higher homocysteine levels than healthy young adults, while there is no significant difference in the distribution of MTHFR C677T genotypes.
    Type of Medium: Online Resource
    ISSN: 1452-8266 , 1452-8258
    URL: Article
    DOI: 10.2478/v10011-008-0029-9
    Language: Unknown
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2009
    detail.hit.zdb_id: 2405112-3
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  • 5
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    Interactions of the eNOS and ACE genes and cigarette smoking in chronic obstructive pulmonary disease
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2023
    In:  Journal of Medical Biochemistry Vol. 42, No. 1 ( 2023), p. 94-104
    Details
    In: Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 42, No. 1 ( 2023), p. 94-104
    Abstract: Background: Chronic obstructive pulmonary disease (COPD) is a complex disorder with unexplained heritability. Interactions of genetic and environmental factors are thought to be crucial in COPD. So, we aim to examine interactions of the endothelial nitric oxide synthase (eNOS) and angiotensin converting enzyme (ACE) genes and cigarette smoking in COPD. Methods: The eNOS G 894T and ACE ID variants were analyzed in 122 COPD patients and 200 controls from Serbia. The effect of the variants on COPD was assessed by logistic regression. Interactions between eNOS, ACE and cigarette smoking in COPD were evaluated using a case-control model. Interaction between the genes was analyzed in silico. Results: No effect of the eNOS G 894T and ACE ID variants on COPD was found in our study. Gene-gene interaction between the eN OS T T and A CE D was identified (p=0.033) in COPD. The interaction is realized within the complex network of biochemical pathways. Gene-environment interactions between the eNOS T and cigarette smoking (p=0.013), and the ACE II and cigarette smoking (p=0.009) were detected in COPD in our study. Conclusions: This is the first research to reveal interactions of the eNOS and ACE genes and cigarette smoking in COPD progressing our understanding of COPD heritability and contributing to the development of appropriate treatments
    Type of Medium: Online Resource
    ISSN: 1452-8258 , 1452-8266
    Uniform Title: Interakcije eNOS i ACE gena i duvanskog dima u hroničnoj opstruktivnoj bolesti pluća
    URL: Article
    DOI: 10.5937/jomb0-34017
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2023
    detail.hit.zdb_id: 2405112-3
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  • 6
    Online Resource
    Online Resource
    Processing of data collected by unmanned aerial photogrammetry systems
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2022
    In:  Tehnika Vol. 77, No. 6 ( 2022), p. 683-689
    Details
    In: Tehnika, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 77, No. 6 ( 2022), p. 683-689
    Abstract: The paper describes the method of application of the platform for processing and managing spatial data collected by drones, as unmanned aerial photogrammetry systems. Software support for data processing and management, as well as model generation for photogrammetry purposes, is provided using the Agisoft Metashape software as an example. The data used for processing is related to the recording of the primary military standard for large lengths and angles, which is located in Kovin. The filming was carried out by a WingtraOne drone. The results of the work confirm the quality of the collected-recorded and processed-output data. The research confirmed the fact that the WingtraOne unmanned aerial photogrammetry system can be a good solution for collecting spatial data and creating some geotopographical materials for the needs of the Military Geographical Institute -"General Stevan Bošković".
    Type of Medium: Online Resource
    ISSN: 0040-2176 , 2560-3086
    Uniform Title: Obrada podataka prikupljenih bespilotnim aerofotogrametrijskim sistemima
    URL: Article
    DOI: 10.5937/tehnika2206683S
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2022
    detail.hit.zdb_id: 2922896-7
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  • 7
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    Direct representation in Roman law with reference to modern law
    University of Belgrade Faculty of Law (Publications) ; 2020
    In:  Anali Pravnog fakulteta u Beogradu Vol. 68, No. 2 ( 2020), p. 123-142
    Details
    In: Anali Pravnog fakulteta u Beogradu, University of Belgrade Faculty of Law (Publications), Vol. 68, No. 2 ( 2020), p. 123-142
    Type of Medium: Online Resource
    ISSN: 0003-2565 , 2406-2693
    Uniform Title: Neposredno zastupanje u rimskom pravu s osvrtom na moderno pravo
    URL: Article
    DOI: 10.5937/AnaliPFB2002124C
    Language: English
    Publisher: University of Belgrade Faculty of Law (Publications)
    Publication Date: 2020
    detail.hit.zdb_id: 2654972-4
    SSG: 2
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  • 8
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    Online Resource
    Influence of different factors on the RAID 0 paired magnetic disk arrays
    National and University Library of the Republic of Srpska ; 2020
    In:  IJEEC - INTERNATIONAL JOURNAL OF ELECTRICAL ENGINEERING AND COMPUTING Vol. 3, No. 2 ( 2020-02-07)
    Details
    In: IJEEC - INTERNATIONAL JOURNAL OF ELECTRICAL ENGINEERING AND COMPUTING, National and University Library of the Republic of Srpska, Vol. 3, No. 2 ( 2020-02-07)
    Abstract: The rapid technological progress has led to a growing need for more data storage space. The appearance of big data requires larger storage space, faster access and exchange of data as well as data security. RAID (Redundant Array of Independent Disks) technology is one of the most cost-effective ways to satisfy needs for larger storage space, data access and protection. However, the connection of multiple secondary memory devices in RAID 0 aims to improve the secondary memory system in a way to provide greater storage capacity, increase both read data speed and write data speed but it is not fault-tolerant or error-free. This paper provides an analysis of the system for storing the data on the paired arrays of magnetic disks in a RAID 0 formation, with different number of queue entries for overlapped I/O, where queue depth parameter has the value of 1 and 4. The paper presents a range of test results and analysis for RAID 0 series for defined workload characteristics. The tests were carried on in Microsoft Windows Server 2008 R2 Standard operating system, using 2, 3, 4 and 6 paired magnetic disks and controlled by Dell PERC 6/i hardware RAID controller. For the needs of obtaining the measurement results, ATTO Disk Benchmark has been used. The obtained results have been analyzed and compared to the expected behavior.
    Type of Medium: Online Resource
    ISSN: 2566-3682
    URL: Article
    DOI: 10.7251/IJEEC1902070D
    Language: Unknown
    Publisher: National and University Library of the Republic of Srpska
    Publication Date: 2020
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  • 9
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    O ZASTUPANJU U PRIVATNOM PRAVU
    Institute of Comparative Law ; 2022
    In:  Strani pravni život Vol. 66, No. 3 ( 2022-11-01), p. 475-488
    Details
    In: Strani pravni život, Institute of Comparative Law, Vol. 66, No. 3 ( 2022-11-01), p. 475-488
    Abstract: Ugovor o nalogu (mandatum) nastao je u rimskom pravu. Na temelju tog ugovora uređeno je posredno zastupanje. Prve moderne građanske kodifikacije priznaju neposredno zastupanje na osnovu punomoćja, ali ga vezuju za ugovor o nalogu. Samostalna ustanova punomoćja nastaje u nemačkom pravu u drugoj polovini XIX veka pri čemu je najveću zaslugu u osamostaljivanju punomoćja od mandata imalo učenje Paula Labanda. U slučaju neposrednog zastupanja pravna dejstva preduzetih pravnih radnji neposredno nastupaju za zastupanog. S obzirom na to da prilikom preduzimanja pravne radnje zastupnik izjavljuje volju, postavlja se pitanje da li izjavljenu volju treba shvatiti kao volju zastupnika ili volju zastupanog. Savremena literatura je u neposrednom zastupanju pre sklona da vidi zamenu volje zastupanog voljom zastupnika. Takvo shvatanje prirode zastupanja u privatnom pravu ima zanimljivo poreklo koje seže u XIII vek.
    Type of Medium: Online Resource
    ISSN: 2620-1127 , 0039-2138
    URL: Article
    DOI: 10.56461/SPZ_22308KJ
    Language: Unknown
    Publisher: Institute of Comparative Law
    Publication Date: 2022
    detail.hit.zdb_id: 2816018-6
    SSG: 2
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  • 10
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    Performance modeling of file system pairs in hypervisor-based virtual environment applied on KVM hypervisor case study
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2022
    In:  Journal of Computer and Forensic Sciences Vol. 1, No. 1 ( 2022), p. 55-75
    Details
    In: Journal of Computer and Forensic Sciences, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 1, No. 1 ( 2022), p. 55-75
    Abstract: This paper proposed an approach to mathematical modeling of the file system performance in a hypervisor-based virtual environment, with special focus on the file system pair interactions. The main goal of this research is to conduct an in-depth analysis of the filesystem pair behavior with respect to the performance costs originating from the employed technologies, such as H-Trees, B-Trees and Copy-on-Write/Overwrite update method, and different application workload types. The modeling provides a collection of hypotheses about the expected behavior. The modeling and the hypotheses are validated based on the results obtained for a specific case study. Our study reports on a file system performance comparison in the context of KVM hypervisor-based full hardware virtualization, application-level benchmarking, and 64-bit Linux filesystems Ext4, XFS, and Btrfs. The Filebench benchmark tool is applied for comprehensive testing of the filesystem performance under fair-play conditions. According to the obtained results, we provide a set of recommendations (i.e., a Knowledge Data Base) for optimal filesystem pair selection for the KVM hypervisor. Finally, it is important to note that the proposed modeling is also applicable to other hypervisor-based virtualizations.
    Type of Medium: Online Resource
    ISSN: 2956-0799 , 2956-0799
    URL: Article
    DOI: 10.5937/1-42712
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2022
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