In:
Kidney and Blood Pressure Research, S. Karger AG, Vol. 41, No. 6 ( 2016), p. 781-793
Kurzfassung:
〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 Delayed graft function (DGF) is associated with adverse outcomes after renal transplantation. Bone morphogenetic protein-2 (BMP-2) is involved in both endothelial function and immunological events. We compared expression of BMP-2 in epigastric artery of renal transplant recipients with immediate graft function (IGF) and DGF. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 79 patients were included in this prospective study. Patients were divided in IGF group (64 patients) and DGF group (15 patients). BMP-2 expression in intima media (BMP2m) and endothelium (BMP2e) of epigastric artery was assessed by immunohistochemistry. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Lower intensity of BMP2e staining was recorded in DGF compared to IGF. In DGF patients, 93% had no expression of BMP2e and 7% had 1 〈 sup 〉 st 〈 /sup 〉 grade expression, compared to 45% and 41% in IGF group, respectively (P=0.001) (P 〈 0.001 for no expression and P = 0.015 for 1 〈 sup 〉 st 〈 /sup 〉 grade expression). Patients who had BMP2e staining positive had lower odds for DGF (OR 0.059 [0.007, 0.477]) and this remained significant even after adjustment for donor and recipient variables, cold ischemia time, and immunological matching (OR 0.038 [0.003, 0.492] ). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our results demonstrate that BMP-2 expression in endothelial cells of epigastric arteries may predict development of DGF.
Materialart:
Online-Ressource
ISSN:
1420-4096
,
1423-0143
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2016
ZDB Id:
1482922-8
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