In:
Gastroenterology Research and Practice, Hindawi Limited, Vol. 2012 ( 2012), p. 1-6
Abstract:
Background/Aim . To identify the etiological role of Helicobacter pylori ( Hp ) and nonsteroidal anti-inflammatory drugs (NSAIDs) in endoscopically diagnosed duodenal ulcers (DUs). Methods . Patients undergoing esophagogastroduodenoscopy in two major hospitals in Antalya and Adiyaman were included in this study and assigned as duodenal ulcer ( n = 152 ; median age: 41.0 (16–71) years; 58.6% males) or control group ( n = 70 ; median age: 41.0 (18–68) years; 57.1% males). Patient demographics, risk factors, and NSAID/acetylsalicylic acid (ASA) use were recorded. Results . HP was more commonly located in the corpus (75.0 versus 50.0%; odds ratio [OR] = 3.00; 95% confidence interval [CI] : 1.66–5.44; P 〈 0.001 ), incisura (75.7 versus 60.0%; OR = 2.07 ; 95% CI: 1.13–3.79; P = 0.017 ), and antrum (80.3 versus 60.0%; OR = 2.71 ; 95% CI: 1.45–5.05; P = 0.001 ) among DU patients than controls. Hp positivity was 84.9% while Hp was negative in 15.1% of patients including those accompanied with NSAID and/or ASA use (9.2%), and those were negative for all three etiological factors (5.9%). Conclusion . Our findings indicate the substantial role of Hp in the pathogenesis of DU disease as identified in 84.9% of DU patients compatible with the background prevalence of 61.4% among age-matched control subjects. Hp was the single causative factor in 44.1% of our patients, while NSAID/ASA exposure was in 9.2%.
Type of Medium:
Online Resource
ISSN:
1687-6121
,
1687-630X
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2012
detail.hit.zdb_id:
2435460-0
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