In:
Learning & Memory, Cold Spring Harbor Laboratory, Vol. 19, No. 5 ( 2012-05), p. 190-193
Kurzfassung:
Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive responses to environmental changes. Serotonin transporter knockout (5-HTT −/− ) rodents show improved reversal learning in addition to orbitofrontal cortex changes. Another form of behavioral flexibility, extradimensional strategy set-shifting (EDSS), heavily depends on the medial prefrontal cortex. This region shows functional changes in 5-HTT −/− rodents as well. Here we subjected 5-HTT −/− rats and their wild-type counterparts to an EDSS paradigm and a supplementary latent inhibition task. Results indicate that 5-HTT −/− rats also show improved EDSS, and indicate that reduced latent inhibition may contribute as an underlying mechanism.
Materialart:
Online-Ressource
ISSN:
1549-5485
DOI:
10.1101/lm.025908.112
Sprache:
Englisch
Verlag:
Cold Spring Harbor Laboratory
Publikationsdatum:
2012
ZDB Id:
2022057-1
SSG:
12
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