GLORIA

GEOMAR Library Ocean Research Information Access

X

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
Materialart
Verlag/Herausgeber
Person/Organisation
Sprache
Erscheinungszeitraum
FID
Fachgebiete(RVK)
  • 1
    Online-Ressource
    Online-Ressource
    Role of Toll‐like receptor 4 signaling in cutaneous chronic graft‐versus‐host disease
    Wiley ; 2015
    In:  Clinical Transplantation Vol. 29, No. 6 ( 2015-06), p. 547-554
    Details
    In: Clinical Transplantation, Wiley, Vol. 29, No. 6 ( 2015-06), p. 547-554
    Kurzfassung: Cutaneous damage is one of the characterized manifestations in chronic graft‐versus‐host disease ( cGVHD ). When local effective immunity in the skin is altered to a dysimmune reaction, cutaneous injuries occur. Toll‐like receptor 4 signaling is regarded as a central mediator of inflammation and organ injury. In this study, we found that TLR 4 m RNA in peripheral blood from patients with cutaneous c GVHD was markedly increased compared with that from non‐ GVHD patients and healthy controls. In addition, NF ‐κ B expression, TLR 4 downstream signaling, and TLR 4‐mediated cytokines, including IL ‐6 and ICAM ‐1, were upregulated. Moreover, ICAM ‐1 was widely distributed in skin biopsies from patients with cutaneous c GVHD . We also found that LPS induced TLR 4‐mediated NF ‐κB activation and IL ‐6 and ICAM ‐1 secretion in human fibroblasts in vitro . Thus, TLR 4, NF ‐κB, IL ‐6, and ICAM ‐1 contribute to the inflammatory response that occurs in cutaneous c GVHD , indicating the TLR 4 pathway may be a novel target for cutaneous c GVHD therapy.
    Materialart: Online-Ressource
    ISSN: 0902-0063 , 1399-0012
    URL: Issue
    URL: Article
    DOI: 10.1111/ctr.2015.29.issue-6
    DOI: 10.1111/ctr.12551
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2015
    ZDB Id: 2739458-X
    ZDB Id: 2004801-4
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    A New Multi-Objective Optimization Design Method for Directional Well Trajectory Based on Multi-Factor Constraints
    MDPI AG ; 2022
    In:  Applied Sciences Vol. 12, No. 21 ( 2022-10-23), p. 10722-
    Details
    In: Applied Sciences, MDPI AG, Vol. 12, No. 21 ( 2022-10-23), p. 10722-
    Kurzfassung: The design of the wellbore trajectory directly affects the construction quality and efficiency of drilling. A good wellbore trajectory is conducive to guiding on-site construction, which can effectively reduce costs and increase productivity. Therefore, further optimization of the wellbore trajectory is inevitable and necessary. Based on this, aiming at the three-segment, five-segment, double-increase-profile extended reach wells, this paper considered the constraints of formation wellbore stability; formation strength; and the determination of the deviation angle, deviation point position, and target range by the work of deflecting tools. In addition, the optimization objective function of the shortest total length of the wellbore, minimum error of the second target, lowest cost, minimum friction of the lifting and lowering string, and minimum torque of rotary drilling were proposed and established. The objective function of the longest extension limit of the horizontal section of the extended reach well is established. Taking the 14-8 block of the Lufeng Oilfield in the eastern South China Sea as an example, the actual data of the field were modeled, and the independence of the objective function was verified by comparing the number of non-inferior solutions of the two objective functions. By normalizing simplified to double-, three-, and four-objective functions, using a genetic algorithm and particle swarm optimization results, it can be found that the new method of optimization design established in this paper has an obvious optimization effect compared with the original design.
    Materialart: Online-Ressource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app122110722
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2704225-X
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    Mesenchymal stromal cells plus basiliximab, calcineurin inhibitor as treatment of steroid-resistant acute graft-versus-host disease: a multicenter, randomized, phase 3, open-label trial
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Hematology & Oncology Vol. 15, No. 1 ( 2022-03-07)
    Details
    In: Journal of Hematology & Oncology, Springer Science and Business Media LLC, Vol. 15, No. 1 ( 2022-03-07)
    Kurzfassung: Steroid-resistant (SR) acute graft-versus-host disease (aGVHD) lacks standard second-line treatment. Mesenchymal stromal cells (MSCs) have potential efficacy in SR aGVHD. We aimed to assess the efficacy and safety of MSCs combined with basiliximab and calcineurin inhibitor as second-line therapy for SR aGVHD. Methods A randomized phase 3 trial involved 203 SR aGVHD patients at nine centers in China (September 2014–March 2019). Participants were randomized at a 1:1 ratio to receive second-line therapy with ( n  = 101) or without ( n  = 102) MSCs. The primary endpoint was the overall response (OR) at day 28. Secondary and safety endpoints included durable OR at day 56, failure-free survival, overall survival (OS), chronic GVHD (cGVHD), infection, hematological toxicity and relapse. Results Of 203 patients, 198 (97.5%; mean age, 30.1 years; 40.4% women) completed the study. The OR at day 28 was higher in the MSC group than the control group (82.8% [82 patients] vs. 70.7% [70] ; odds ratio, 2.00; 95% confidence interval [CI], 1.01–3.94; P  = 0.043). The durable OR at day 56 was also higher in the MSC group (78.8% [78 patients] vs. 64.6% [64] ; odds ratio, 2.02; 95% CI, 1.08–3.83; P  = 0.027). The median failure-free survival was longer in the MSC group compared with control (11.3 months vs. 6.0 months; hazard ratio (HR) 0.68; 95% CI, 0.48–0.95, P  = 0.024). The 2-year cumulative incidence of cGVHD was 39.5% (95% CI, 29.3–49.4%) and 62.7% (51.4–72.1%) in the MSC and control groups (HR 0.55, 95% CI, 0.36–0.84; P  = 0.005). Within 180 days after study treatments, the most common grade 3 and 4 adverse events were infections (65 [65.7%] in the MSC group vs. 78 [78.8%] in the control group) and hematological toxicity (37 [37.4%] vs. 53 [53.5%] ). The 3-year cumulative incidence of tumor relapse was 10.1% (95% CI, 5.2–17.1) and 13.5% (7.5–21.2%) in the MSC and control groups, respectively (HR 0.75, 95% CI, 0.34–1.67, P  = 0.610). Conclusions MSCs plus second-line treatments increase the efficacy of SR aGVHD, decrease drug toxicity of second-line drugs and cGVHD without increasing relapse, and are well-tolerated. MSCs could be recommended as a second-line treatment option for aGVHD patients. Trial registration clinicaltrials.gov identifier: NCT02241018. Registration date: September 16, 2014, https://clinicaltrials.gov/ct2/show/NCT02241018 .
    Materialart: Online-Ressource
    ISSN: 1756-8722
    URL: Article
    DOI: 10.1186/s13045-022-01240-4
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2022
    ZDB Id: 2429631-4
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    Antioxidant Profile of 1‐Monocaffeoyl Glycerol in Lipophobic/Lipophilic Media
    Wiley ; 2019
    In:  Journal of Food Science Vol. 84, No. 8 ( 2019-08), p. 2091-2100
    Details
    In: Journal of Food Science, Wiley, Vol. 84, No. 8 ( 2019-08), p. 2091-2100
    Kurzfassung: Oxidative stress has been generally considered as one trigger of organism imbalance, resulting in lipid peroxidation, DNA damage and protein oxidation, which could be relieved by antioxidant supplement or endogenous antioxidant system. In present study, 1‐monocaffeoyl glycerol (1‐MCG), an amphipathic caffeic acid natural derivative, was enzymatically synthesized by Lipozyme 435, and its antioxidant profile in both lipophilic and lipophobic media was evaluated. The 1‐MCG was identified by HPLC‐UV, HPLC‐ESI‐MS, and 1 H/ 13 C‐NMR. Subsequently, antioxidant assays in lipophilic (DPPH assay) and lipophobic (ABTS, ORAC, erythrocyte hemolysis, ROS, MDA, and GPx assays) systems were explored. The better and lasting DPPH· and ABTS +· inhibitions of 1‐MCG than caffeic acid (CA) were related to its better solubilities in ethanol/water media and electron transfer ability. ORAC results suggested the radical scavenging activities of 1‐MCG (5 to 40 µM) were higher than Trolox. Furthermore, the effectiveness of 1‐MCG against AAPH‐induced erythrocytes oxidation indicated that 1‐MCG can effectively inhibit hemolysis. ESEM was also applied to verify the hemolysis inhibition and morphology preservation abilities of 1‐MCG. Besides, results showed 1‐MCG was able to prevent ROS from invasion, reduce production of MDA, up‐regulated GPx activity, terminate lipid peroxidation, and maintain the integrity of the structure and function of erythrocytes. Practical Application As an amphiphilic caffeic acid derivative, 1‐monocaffeoyl glycerol was synthesized, purified, and identified. 1‐Monocaffeoyl glycerol could significantly eliminate radicals including DPPH·, ABTS +· , and AAPH in ethanol, water, and PBS system, respectively. 1‐Monocaffeoyl glycerol could protect erythrocyte from AAPH induced hemolysis.
    Materialart: Online-Ressource
    ISSN: 0022-1147 , 1750-3841
    URL: Issue
    URL: Article
    DOI: 10.1111/jfds.v84.8
    DOI: 10.1111/1750-3841.14732
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2019
    ZDB Id: 2006705-7
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 5
    Online-Ressource
    Online-Ressource
    Mesenchymal stem cells reversibly de-differentiate myofibroblasts to fibroblast-like cells by inhibiting the TGF-β-SMAD2/3 pathway
    Springer Science and Business Media LLC ; 2023
    In:  Molecular Medicine Vol. 29, No. 1 ( 2023-04-25)
    Details
    In: Molecular Medicine, Springer Science and Business Media LLC, Vol. 29, No. 1 ( 2023-04-25)
    Kurzfassung: Myofibroblasts (MFB), one of the major effectors of pathologic fibrosis, mainly derived from the activation of fibroblast to myofibroblast transition (FMT). Although MFBs were historically considered terminally differentiated cells, their potential for de-differentiation was recently recognized and implied with therapeutic value in treating fibrotic diseases, for instance, idiopathic pulmonary fibrosis (IPF) and post allogeneic hematopoietic stem cell transplantation bronchiolitis obliterans (BO). During the past decade, several methods were reported to block or reverse MFB differentiation, among which mesenchymal stem cells (MSC) have demonstrated potential but undetermined therapeutic values. However, the MSC-mediated regulation of FMT and underlying mechanisms remained largely undefined. Method By identifying TGF-β1 hypertension as the pivotal landmark during the pro-fibrotic FMT, TGF-β1-induced MFB and MSC co-culture models were established and utilized to investigate regulations by MSC on FMT in vitro. Methods including RNA sequencing (RNA-seq), Western blot, qPCR and flow cytometry were used. Result Our data revealed that TGF-β1 readily induced invasive signatures identified in fibrotic tissues and initiated MFB differentiation in normal FB. MSC reversibly de-differentiated MFB into a group of FB-like cells by selectively inhibiting the TGF-β-SMAD2/3 signaling. Importantly, these proliferation-boosted FB-like cells remained sensitive to TGF-β1 and could be re-induced into MFB. Conclusion Our findings highlighted the reversibility of MSC-mediated de-differentiation of MFB through TGF-β-SMAD2/3 signaling, which may explain MSC's inconsistent clinical efficacies in treating BO and other fibrotic diseases. These de-differentiated FB-like cells are still sensitive to TGF-β1 and may further deteriorate MFB phenotypes unless the pro-fibrotic microenvironment is corrected.
    Materialart: Online-Ressource
    ISSN: 1528-3658
    URL: Article
    DOI: 10.1186/s10020-023-00630-9
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2023
    ZDB Id: 1475577-4
    ZDB Id: 1283676-X
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 6
    Online-Ressource
    Online-Ressource
    Senescent Mesenchymal Stem Cells in Myelodysplastic Syndrome: Functional Alterations, Molecular Mechanisms, and Therapeutic Strategies
    Frontiers Media SA ; 2021
    In:  Frontiers in Cell and Developmental Biology Vol. 8 ( 2021-2-11)
    Details
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 8 ( 2021-2-11)
    Kurzfassung: Myelodysplastic syndrome (MDS) is a group of clonal hematopoietic disorders related to hematopoietic stem and progenitor cell dysfunction. However, therapies that are currently used to target hematopoietic stem cells are not effective. These therapies are able to slow the evolution toward acute myeloid leukemia but cannot eradicate the disease. Mesenchymal stem cells (MSCs) have been identified as one of the main cellular components of the bone marrow microenvironment, which plays an indispensable role in normal hematopoiesis. When functional and regenerative capacities of aging MSCs are diminished, some enter replicative senescence, which promotes inflammation and disease progression. Recent studies that investigated the contribution of bone marrow microenvironment and MSCs to the initiation and progression of the disease have offered new insights into the MDS. This review presents the latest updates on the role of MSCs in the MDS and discusses potential targets for the treatment of MDS.
    Materialart: Online-Ressource
    ISSN: 2296-634X
    URL: Article
    DOI: 10.3389/fcell.2020.617466
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2021
    ZDB Id: 2737824-X
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 7
    Online-Ressource
    Online-Ressource
    Selinexor plus low-dose dexamethasone in Chinese patients with relapsed/refractory multiple myeloma previously treated with an immunomodulatory agent and a proteasome inhibitor (MARCH): a phase II, single-arm study
    Springer Science and Business Media LLC ; 2022
    In:  BMC Medicine Vol. 20, No. 1 ( 2022-12)
    Details
    In: BMC Medicine, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2022-12)
    Kurzfassung: Selinexor 80 mg combined with low-dose dexamethasone (Sd) demonstrated significant clinical benefit in patients with relapsed/refractory multiple myeloma (RRMM) who had disease refractory to a proteasome inhibitor (PI), an immunomodulator (IMiD), and an anti-CD38 monoclonal antibody based on a global phase II STORM study. The present study, MARCH, addresses China regulatory needs to further validate the data from STORM in Chinese patients with RRMM. Methods The MARCH study was conducted at 17 sites in China, where eligible Chinese RRMM patients who had disease refractory to PI and IMiD were enrolled. Selinexor 80 mg combined with dexamethasone 20 mg was administered orally on day 1 and day 3 of each week in 4-week cycles. The primary endpoint was the overall response rate (ORR) per an independent review committee, with the null hypothesis of ≤15%. Patients who received at least 1 dose of study treatment were included in the safety population. The pharmacokinetic (PK) profile was characterized by parameter and ethnicity sensitivity analyses. Results A total of 82 patients with RRMM were enrolled in the study, with a median age of 60 years. Of the 82 patients, 55 patients (67.1%) had high-risk cytogenetic abnormalities, defined as one or more of del 17p13, t(4;14), t(14;16), or 1q amplification identified by fluorescence in situ hybridization (FISH); 18 patients (22.0%) had abnormal renal function. Enrolled patients were heavily pre-treated with a median prior regimen number of 5. All 82 patients (100%) were refractory to both PI and IMiD, including 20 patients (24.4%) categorized as triple-class refractory population (refractory to PI, IMiD, and daratumumab). Ten patients (12.2%) had undergone CAR-T therapy. ORR was 29.3% (95% CI 19.7, 40.4) with a median DOR of 4.7 months. The median PFS and OS were 3.7 and 13.2 months, respectively. ORR was 25.0% (95% CI 8.7, 49.1) in the triple-class refractory population. Efficacy was consistent across various subgroups. The most frequent grade 3/4 adverse events (AEs) included anemia (57.3%), thrombocytopenia (51.2%), lymphopenia (42.7%), neutropenia (40.2%), hyponatremia (29.3%), and lung infection (26.8%). Serious AEs were reported in 54.9% of patients. No significant drug accumulation was shown following multiple administrations. No human PK ethnicity difference was identified between Chinese and western patients. Conclusions With an encouraging ORR, the MARCH study has demonstrated that selinexor combined with low-dose dexamethasone (Sd) delivers meaningful clinical benefit to Chinese patients with RRMM, including triple-class refractory patients. AEs were expected and manageable with supportive care and dose modification. Trial registration ClinicalTrials.gov, NCT03944057 (May 09, 2019); Chinadrugtrials.org.cn , CTR20190858 (June 05, 2019)
    Materialart: Online-Ressource
    ISSN: 1741-7015
    URL: Article
    DOI: 10.1186/s12916-022-02305-4
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2022
    ZDB Id: 2131669-7
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 8
    Online-Ressource
    Online-Ressource
    The Synergistic Effects of Decitabine Combined with Arsenic Trioxide (ATO) in the Human Myelodysplastic Syndrome Cell Line SKM-1
    Springer Science and Business Media LLC ; 2016
    In:  Indian Journal of Hematology and Blood Transfusion Vol. 32, No. 4 ( 2016-12), p. 412-417
    Details
    In: Indian Journal of Hematology and Blood Transfusion, Springer Science and Business Media LLC, Vol. 32, No. 4 ( 2016-12), p. 412-417
    Materialart: Online-Ressource
    ISSN: 0971-4502 , 0974-0449
    URL: Article
    DOI: 10.1007/s12288-015-0632-0
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2016
    ZDB Id: 2422370-0
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 9
    Online-Ressource
    Online-Ressource
    Correction to: A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia
    Springer Science and Business Media LLC ; 2019
    In:  Journal of Hematology & Oncology Vol. 12, No. 1 ( 2019-12)
    Details
    In: Journal of Hematology & Oncology, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2019-12)
    Kurzfassung: The original article [1] contains an error in authorship whereby author, Robert Weinkove’s name is mistakenly inverted. The configuration noted in this Correction article should be considered instead along with author’s updated affiliation.
    Materialart: Online-Ressource
    ISSN: 1756-8722
    URL: Article
    DOI: 10.1186/s13045-019-0816-4
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2019
    ZDB Id: 2429631-4
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 10
    Online-Ressource
    Online-Ressource
    Gene regulatory network of carpel number variation in cucumber
    The Company of Biologists ; 2020
    In:  Development
    Details
    In: Development, The Company of Biologists
    Kurzfassung: The WUSCHEL-CLAVATA3 pathway genes play essential role in shoot apical meristem maintenance and floral organ development, and under intense selection during crop domestication. The carpel number is an important fruit trait affecting fruit shape, size, and internal quality in cucumber, but the molecular mechanism remains elusive. Here, we found that CsCLV3 expression was negatively correlated with carpel number in cucumber cultivars. CsCLV3-RNAi led to increased number of petals and carpels, whereas overexpression of CsWUS resulted in more sepals, petals and carpels, suggesting that CsCLV3 and CsWUS function as a negative and a positive regulator for carpel number variation, respectively. Biochemical analyses indicated that CsWUS directly binds to the promoter of CsCLV3 and activates its expression. Overexpression of CsFUL1A, a FRUITFULL-like MADS-box gene, resulted in more petals and carpels. CsFUL1A can directly bind to CsWUS promoter to stimulate its expression. Further, we found that auxin participates in carpel number variation in cucumber through interaction of CsARF14 with CsWUS. Therefore, we identified a gene regulatory pathway involving CsCLV3, CsWUS, CsFUL1A and CsARF14 in determining carpel number variation in an important vegetable crop-cucumber.
    Materialart: Online-Ressource
    ISSN: 1477-9129 , 0950-1991
    URL: Article
    DOI: 10.1242/dev.184788
    Sprache: Englisch
    Verlag: The Company of Biologists
    Publikationsdatum: 2020
    ZDB Id: 2007916-3
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...