In:
European Journal of Organic Chemistry, Wiley, Vol. 2013, No. 11 ( 2013-04), p. 2091-2105
Kurzfassung:
The readily available and polyfunctionalized 3‐chloro‐6‐fluoroquinoxalin‐2(1 H )‐one 4‐oxide, derived from the efficient one‐step annulation reaction of 1,1,2‐trichloro‐2‐nitroethene with 4‐fluoroaniline, was selectively modified at the chloronitrone and the amide units, leading to more than 30 new quinoxaline derivatives with a unique substitution pattern in good to excellent yields. In addition, the electronic properties of the versatile starting compound were computed by means of density functional theory, which gave a reasonable explanation for its unique reactivity. The antimalarial activity of all hitherto unknown compounds has been investigated.
Materialart:
Online-Ressource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2013.11
DOI:
10.1002/ejoc.201201569
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2013
ZDB Id:
1410000-9
ZDB Id:
1475010-7
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