In:
Journal of Neurochemistry, Wiley, Vol. 90, No. 2 ( 2004-07), p. 332-339
Kurzfassung:
Synaptic scaffolding molecule (S‐SCAM) is a synaptic protein that consists of PDZ domains, a guanylate kinase domain, and WW domains. It interacts with N ‐methyl‐ d ‐aspartate receptor subunits, neuroligin, and β‐catenin. Here, we identified Axin as a novel binding partner of S‐SCAM. Axin was co‐immunoprecipitated with S‐SCAM from rat brain, detected in the post‐synaptic density fraction in rat brain subcellular fractionation, and partially co‐localized with S‐SCAM in neurons. The guanylate kinase domain of S‐SCAM directly bound to the GSK3β‐binding region of Axin. S‐SCAM formed a complex with β‐catenin and Axin, but competed with GSK3β for Axin‐binding. Thereby, S‐SCAM inhibited the Axin‐mediated phosphorylation of β‐catenin by GSK3β.
Materialart:
Online-Ressource
ISSN:
0022-3042
,
1471-4159
DOI:
10.1111/jnc.2004.90.issue-2
DOI:
10.1111/j.1471-4159.2004.02497.x
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2004
ZDB Id:
2020528-4
SSG:
12
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