In:
Canadian Journal of Chemistry, Canadian Science Publishing, Vol. 80, No. 8 ( 2002-08-01), p. 875-884
Kurzfassung:
Transannular DielsAlder (TADA) adducts constitute a collection of rigid structures, whose conformational diversity is rich. It is possible to design such specifically functionalized molecules capable of binding to known biological targets by molecular modelling MCSSHOOK (multiple copy simultaneous search). Here we show that such carefully designed compounds can be easily built from small synthons. TADA adducts are very interesting due to their huge conformational diversity, their rigidity (biological interest), and their ease of synthesis (chemical interest).Key words: tricycles, synthesis, transannular DielsAlder, macrocyclization, conformation, diversity.
Materialart:
Online-Ressource
ISSN:
0008-4042
,
1480-3291
Sprache:
Englisch
Verlag:
Canadian Science Publishing
Publikationsdatum:
2002
ZDB Id:
1482256-8
Permalink