In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 4 ( 2022-4-14), p. e0266974-
Kurzfassung:
Cerebral Small Vessel Disease (CSVD), a progressive degenerative disorder of small caliber cerebral vessels, represents a major contributor to stroke and vascular dementia incidence worldwide. We sought to conduct a systematic review of the role of retinal biomarkers in diagnosis and characterization of CSVD. Methods We conducted a systematic review of MEDLINE, PubMed, Scopus, the Cochrane Library Database, and Web of Science. We identified studies of sporadic CSVD (including CSVD not otherwise specified, Cerebral Amyloid Angiopathy, and Hypertensive Arteriopathy) and the most common familial CSVD disorders (including CADASIL, Fabry disease, and MELAS). Included studies used one or more of the following tools: visual fields assessment, fundus photography, Optical Coherence Tomography and OCT Angiography, Fluorescein Angiography, Electroretinography, and Visual Evoked Potentials. Results We identified 48 studies of retinal biomarkers in CSVD, including 9147 cases and 12276 controls. Abnormalities in retinal vessel diameter (11 reports, n = 11391 participants), increased retinal vessel tortuosity (11 reports, n = 617 participants), decreased vessel fractal dimension (5 reports, n = 1597 participants) and decreased retinal nerve fiber layer thickness (5 reports, n = 4509 participants) were the biomarkers most frequently associated with CSVD. We identified no reports conducting longitudinal retinal evaluations of CSVD, or systematically evaluating diagnostic performance. Conclusion Multiple retinal biomarkers were associated with CSVD or its validated neuroimaging biomarkers. However, existing evidence is limited by several shortcomings, chiefly small sample size and unstandardized approaches to both biomarkers’ capture and CSVD characterization. Additional larger studies will be required to definitively determine whether retinal biomarkers could be successfully incorporated in future research efforts and clinical practice.
Materialart:
Online-Ressource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0266974
DOI:
10.1371/journal.pone.0266974.g001
DOI:
10.1371/journal.pone.0266974.g002
DOI:
10.1371/journal.pone.0266974.g003
DOI:
10.1371/journal.pone.0266974.t001
DOI:
10.1371/journal.pone.0266974.t002
DOI:
10.1371/journal.pone.0266974.t003
DOI:
10.1371/journal.pone.0266974.t004
DOI:
10.1371/journal.pone.0266974.t005
DOI:
10.1371/journal.pone.0266974.t006
DOI:
10.1371/journal.pone.0266974.t007
DOI:
10.1371/journal.pone.0266974.s001
DOI:
10.1371/journal.pone.0266974.s002
DOI:
10.1371/journal.pone.0266974.s003
DOI:
10.1371/journal.pone.0266974.r001
DOI:
10.1371/journal.pone.0266974.r002
DOI:
10.1371/journal.pone.0266974.r003
DOI:
10.1371/journal.pone.0266974.r004
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2022
ZDB Id:
2267670-3
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