In:
Journal of Cellular and Molecular Medicine, Wiley, Vol. 14, No. 11 ( 2010-11), p. 2561-2569
Kurzfassung:
Clinical background Bone physiology – molecular cues and cellular responses Standard treatment of segmental bone defects Tissue engineering The challenge of angiogenesis Conclusions Several conditions in clinical orthopaedic practice can lead to the development of a diaphyseal segmental bone defect, which cannot heal without intervention. Segmental bone defects have been traditionally treated with bone grafting and/or distraction osteogenesis, methods that have many advantages, but also major drawbacks, such as limited availability, risk of disease transmission and prolonged treatment. In order to overcome such limitations, biological treatments have been developed based on specific pathways of bone physiology and healing. Bone tissue engineering is a dynamic field of research, combining osteogenic cells, osteoinductive factors, such as bone morphogenetic proteins, and scaffolds with osteoconductive and osteoinductive attributes, to produce constructs that could be used as bone graft substitutes for the treatment of segmental bone defects. Scaffolds are usually made of ceramic or polymeric biomaterials, or combinations of both in composite materials. The purpose of the present review is to discuss in detail the molecular and cellular basis for the development of bone tissue engineering constructs.
Materialart:
Online-Ressource
ISSN:
1582-1838
,
1582-4934
DOI:
10.1111/jcmm.2010.14.issue-11
DOI:
10.1111/j.1582-4934.2010.01062.x
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2010
ZDB Id:
2076114-4
ZDB Id:
2074559-X
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