In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-06-05)
Kurzfassung:
The gut microbiota in chicken has long been studied, mostly from the perspective of growth performance. However, there are some immunological studies regarding gut homeostasis in chicken. Although CD4 + CD25 + T cells are reported to act as regulatory T cells (Tregs) in chicken, there have been no studies showing the relationship between gut microbiota and Tregs. Therefore, we established a model for ‘antibiotics (ABX)-treated chickens’ through administration of an antibiotic cocktail consisting of ampicillin, gentamycin, neomycin, metronidazole, and vancomycin in water for 7 days. CD4 + CD8 − CD25 + and CD4 + CD8 + CD25 + T cells in cecal tonsils were significantly decreased in this model. Gram-positive bacteria, especially Clostridia, was responsible for the changes in CD4 + CD8 − CD25 + or CD4 + CD8 + CD25 + T cells in cecal tonsils. Feeding ABX-treated chickens with acetate recovered CD4 + CD8 − CD25 + and CD4 + CD8 + CD25 + T cells in cecal tonsils. GPR43, a receptor for acetate, was highly expressed in CD4 + CD8 − CD25 + T cells. In conclusion, our study demonstrated that the gut microbiota can regulate the population of CD4 + CD8 − CD25 + and CD4 + CD8 + CD25 + T cells, and that acetate is responsible for the induction of CD4 + CD8 − CD25 + T cells in cecal tonsils via GPR43.
Materialart:
Online-Ressource
ISSN:
2045-2322
DOI:
10.1038/s41598-018-26763-0
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2018
ZDB Id:
2615211-3
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