In:
Physiological Research, Institute of Physiology of the Czech Academy of Sciences
Kurzfassung:
Bupivacaine is a widely used long-acting local anaesthetic. In
clinical practice, a mixture of bupivacaine and lidocaine is often used in order to combine the faster onset of sensory blockade of
lidocaine with more profound and longer duration of blockade by bupivacaine. The aim of this study was to compare the
cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocaine in the isolated rat heart and to
estimate whether or not the addition of lidocaine in clinically relevant concentration increases bupivacaine-induced toxicity.
Experiments were performed on 21 adult male rats divided into three groups: B (6 µg/ml bupivacaine), BL (6 µg/ml bupivacaine
and 12 µg/ml lidocaine) and L (12 µg/ml lidocaine). The experiment consisted of three 30 min periods: stabilisation,
perfusion and washout. The isolated hearts were perfused according to Langendorff with Krebs-Henseleit solution at
constant pressure (80 mmHg) and 37 °C (CaCl2 1.25 mM) and the heart rate (based on RR interval assessment), PQ and QRS
intervals were measured. The present study shows that the mixture of tested anaesthetics – bupivacaine and lidocaine –
impairs the intraventricular conduction parameters (QRS interval prolongation) to a lesser extent than bupivacaine itself, and that
this effect is marked mainly at the beginning of perfusion.
Materialart:
Online-Ressource
ISSN:
1802-9973
,
0862-8408
DOI:
10.33549/physiolres.932014
Sprache:
Englisch
Verlag:
Institute of Physiology of the Czech Academy of Sciences
Publikationsdatum:
2010
ZDB Id:
2100162-5
SSG:
12
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