Keywords:
Cellular signal transduction.
;
Electronic books.
Type of Medium:
Online Resource
Pages:
1 online resource (357 pages)
Edition:
1st ed.
ISBN:
9780080541075
Series Statement:
Issn Series
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=300663
DDC:
571
Language:
English
Note:
Cover -- Preface -- List of Contributors -- Contents -- Chapter 1. Ischemic Tolerance in the Brain: Models and Mechanisms -- 1. Introduction -- 2. Myocardial preconditioning -- 3. Brain preconditioning -- 4. Hibernation and hypoxia tolerance -- 5. Conclusions -- References -- Chapter 2. Regulation of Gene Expression by Hypoxia in Lung Alveolar Epithelial Cells -- 1. Introduction -- 2. Effect of hypoxia on Na transport proteins -- 3. Effect of hypoxia on proteins involved in glucose metabolism -- 4. Effect of hypoxia on vascular growth factor expression -- 5. Effect of hypoxia on adhesion molecules expression -- 6. Role of hypoxia-inducible factors in regulation of gene expression -- 7. Conclusion -- References -- Chapter 3. A Profile of the Metabolic Responses to Anoxia in Marine Invertebrates -- 1. Introduction -- 2. Metabolic response to anoxia -- 3. Macromolecular synthesis -- 4. Gene expression -- 5. Triggering the anoxic response -- 6. Transcription factors -- 7. Perspectives -- References -- Chapter 4. The Role of Adenosine in Tissue Protection During Ischemia-Reperfusion -- 1. Introduction -- 2. Endogenous adenosine is protective in ischemia-reperfusion injury -- 3. Adenosine receptors -- 4. Adenosine-stimulated cell pathways and effector activities -- 5. Conclusions and clinical implications -- References -- Chapter 5. NF-kB Function in Inflammation, Cellular Stress and Disease -- 1. Introduction -- 2. Activation of NF-kB -- 3. Attenuation of the NF-kB response -- 4. The inflammatory stress response -- 5. Rheumatoid arthritis -- 6. NF-kB and the airway -- 7. NF-kB and gastro-intestinal disease -- 8. NF-kB and reproductive function -- 9. Other NF-kB associated diseases -- 10. Conclusions -- Acknowledgements -- References -- Chapter 6. MAPping Stress Survival in Yeasts: From the Cell Surface to the Nucleus -- 1. Introduction.
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2. The Hog1 MAPK cascade in budding yeast -- 3. The Spc1 MAPK cascade in fission yeast -- 4. Concluding remarks -- Acknowledgements -- References -- Chapter 7. Calcium Signaling Mediated by Cyclic ADP-Ribose and NAADP: Roles in Cellular Response to Stress -- 1. Introduction -- 2. Calcium signaling mediated by cyclic ADP-ribose and NAADP -- 3. cADPR and plant response to environmental stress -- 4. cADPR and sponge response to heat stress -- 5. cADPR in bacterial infection and immune responses -- 6. Conclusion -- References -- Chapter 8. The Cellular and Molecular Basis of the Detection of Pain -- 1. Introduction -- 2. Ion channels involved in nociception -- 3. Sensitisation of nociceptors -- 4. Pain detection in the viscera -- Acknowledgements -- References -- Chapter 9. Acquired Freezing Tolerance in Higher Plants: The Sensing and Molecular Responses to Low Nonfreezing Temperatures -- 1. Introduction -- 2. Freezing injury in plants -- 3. Biochemical changes associated with cold acclimation -- 4. Alteration of gene expression associated with cold acclimation -- 5. CBF transcription factors define a major cold response pathway in flowering plants -- 6. Mutational analysis of freezing tolerance -- 7. Emerging signaling processes regulating cold acclimation -- 8. Molecular and genetic analysis of signaling transduction of stress responses -- 9. Multiple signal pathways mediate cold acclimation -- 10. Hunting for the temperature sensors -- 11. Conclusions and perspectives -- Acknowledgements -- Disclaimer -- References -- Chapter 10. Sensing and Responses to Low Temperature in Cyanobacteria -- 1. Introduction -- 2. Cellular responses to low-temperature stress -- 3. Cold-inducible genes and their regulation -- 4. Membrane fluidity as a link between low temperatures and the induction of gene expression.
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5. Sensors and transducers of low-temperature signals -- 6. Conclusions and perspectives -- References -- Chapter 11. Dehydrins -- 1. Introduction -- 2. Dehydrins -- 3. Dehydrin gene expression -- 4. Association with abiotic stresses and anticipated functions -- 5. Seed dehydrins -- 6. Localization of dehydrins -- 7. Functional studies of dehydrins -- 8. Conclusions -- References -- Chapter 12. Dual Role of Membranes in Heat Stress: As Thermosensors They Modulate the Expression of Stress Genes and, by Interacting with Stress Proteins, Re-organize Their Own Lipid Order and Functionality -- 1. Introduction -- 2. Membranes as "cellular thermometers -- 3. Pre-existing membrane lipid composition and physical state determines the heat induced membrane damage and has a primary and major effect on cell viability -- 4. HSPs are actively involved in the repair of the damaged membranes in heat-stressed cells by association with the membranes -- Acknowledgements -- References -- Chapter 13. Cellular Adaptation to Amino Acid Availability: Mechanisms Involved in the Regulation of Gene Expression and Protein Metabolism -- 1. Introduction -- 2. Regulation of amino acid metabolism and homeostasis in the whole animal -- 3. Amino acid control of gene expression -- 4. Amino acid control of protein metabolism -- 5. Conclusion -- References -- Chapter 14. Amino Acid-dependent Signal Transduction -- 1. Introduction: amino acid stimulation of S6 phosphorylation -- 2. Amino acids and p70S6 kinase activation -- 3. Amino acid stimulation of 4E-BP1 phosphorylation -- 4. Amino acid stimulation of eEF2kinase -- 5. Amino acid stimulation of elF2a -- 6. Involvement of PI 3-kinase and protein kinase B in amino acid-dependent signaling? Amino acid/insulin synergy -- 7. Amino acids and mTOR activation -- 8. Amino acids and protein phosphatases.
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9. Negative feedback by amino acid signaling on insulin signaling -- 10. mTOR as an ATP sensor. Involvement of AMP-dependent protein kinase? -- 11. Amino acid signaling in B-cells -- 12. Amino acid signaling in vivo -- 13. Amino acid signaling as a function of age -- 14. Mechanisms -- 15. Conclusions -- Acknowledgement -- References -- Chapter 15. Signal Transduction Pathways Involved in the Regulation of Drug Metabolizing Enzymes -- 1. Introduction -- 2. Drug Metabolizing Enzymes (DMEs) -- 3. The antioxidant response element (ARE) -- 4. Transacting factors regulating the expression of Phase II enzymes -- 5. Mitogen-activated protein kinases (MAPKs) -- 6. MAPK activation by phenolic compounds and isothiocyanates: induction of Phase II enzymes -- 7. MAPK activation and ARE-mediated gene expression via Nrf2-dependent mechanism -- 8. Concluding remarks -- Acknowledgements -- References -- Chapter 16. Biological Actions of lnfrared Radiation -- 1. Introduction -- 2. Electromagnetic radiation and human health -- 3. Cellular interactions with IR radiation -- 4. Gene and protein induction -- 5. Perspectives -- Acknowledgements -- References -- Chapter 17. Energy Sensing and Photostasis in Photoautotrophs -- 1. Introduction -- 2. Energy sensing and redox status -- 3. Photosynthetic electron transport -- 4. Excitation pressure and redox sensing -- 5. Photostasis -- 6. Excitation pressure, photoprotection and photostasis -- 7. Summary -- Acknowledgements -- References -- Chapter 18. The Uncoupling Proteins Family: From Thermogenesis to the Regulation of ROS -- 1. Introduction -- 2. UCP1 belongs to the mitochondrial anion carriers family -- 3. The discovery of the uncoupling proteins homologues -- 4. Lessons from the UCP knockout mice -- 5. UCP family, from thermogenesis to the regulation of ROS -- Acknowledgements -- References.
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Chapter 19. Regulation of Proliferation, Differentiation and Apoptosis of Brown Adipocytes: Signal Transduction Pathways Involved -- 1. Introduction -- 2. Development, differentiation and involution of brown adipose tissue -- 3. Transcriptional control of brown adipose tissue differentiation -- 4. Regulation of proliferation of brown adipocytes: signals and signal transduction pathways involved -- 5. Regulation of differentiation of brown adipocytes: signals and signal transduction pathways involved -- 6. Apoptosis of brown adipocytes: signals and signal transduction pathways involved in its regulation -- 7. Conclusions -- Acknowledgements -- References -- Chapter 20. Control Analysis of Metabolic Depression -- 1. Introduction -- 2. What is control analysis? -- 3. Applications of control analysis -- 4. Theory -- 5. Examples -- 6. Regulation analysis of cell signalling in pathways that initiate metabolic depression -- 7. Summary -- References -- Chapter 21. Evolution of Physiological Adaptation -- 1. Introduction -- 2. Evolutionary physiology: appropriate comparisons -- 3. Variation in physiological and biochemical traits -- 4. Evolution of thermal acclimation -- 5. Conclusions -- Acknowledgement -- References -- Chapter 22. Dynamic Use of cDNA Arrays: Heterologous Probing for Gene Discovery and Exploration of Organismal Adaptation to Environmental Stress -- 1. Introduction -- 2. Differential gene expression: the early years -- 3. DNA arrays: a brief history -- 4. Evaluation of mammalian hibernation via cDNA array screening -- 5. Reproducibility and reliability -- 6. Outlook -- References -- Index.
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