Keywords:
Genetic regulation.
;
Electronic books.
Type of Medium:
Online Resource
Pages:
1 online resource (381 pages)
Edition:
1st ed.
ISBN:
9780080534145
Series Statement:
Issn Series ; v.Volume 1
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=312738
DDC:
571.74
Language:
English
Note:
Front Cover -- Hormones and Signaling -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Glucocorticoids and Oxysterols in Lymphoid Apoptosis -- I. Introduction -- II. Mechanisms of Action of the Glucocorticoid Receptor -- III. Actions of Oxysterols on Lymphoid Cells -- IV. Apoptosis -- V. Glucocorticoids and Oxysterols Cause Apoptosis of CEM Cells -- VI. Conclusions -- References -- Chapter 2. RAGE: A Receptor with a Taste for Multiple Ligands and Varied Pathophysiologic States -- I. Introduction -- II. Identification and Characterization of RAGE -- III. Expression and Functions of RAGE: Endothelial Cells and Mononuclear Phagocytes -- IV. RAGE and Diabetes -- V. RAGE and Amphoterin -- VI. RAGE and Alzheimer's Disease -- VII. Hypothesis -- References -- Chapter 3. The Function and Regulation of the G-Protein-Coupled Receptor Kinases -- I. Introduction -- II. The Regulation of Cellular Signaling -- III. The G-Protein-Coupled Receptor Kinases -- IV. The Regulation of the G-Protein-Coupled Receptor Kinases -- V. Kinase Enzymology -- VI. Receptor-Kinase Specificity -- VII. Animal Models -- VIII. Physiological Significance -- IX. Conclusions -- References -- Chapter 4. Characteristics and Function of the Novel Estrogen Receptor β -- I. Introduction -- II. Cloning of ERβ cDNA -- III. Ligand-Binding Characteristics of ERβ Protein -- IV. Transactivation Function of ERβ Protein -- V. Expression of ERβ mRNA -- VI. Physiological Role of ER/3 Protein -- VII. Concluding Remarks -- References -- Chapter 5. EGF Family Receptors and Their Ligands in Human Cancer -- I. Introduction -- II. EGF Family Receptors -- III. EGF-like Growth Factors -- IV. Activation of EGF Family Receptors -- V. Clinical Significance of EGF Family Receptors -- VI. Potential Clinical Application by Targeting of EGF Family Receptor Members and Ligands -- VII. Conclusion.
,
References -- Chapter 6. Fertilization: Common Molecular Signaling Pathways across the Species -- I. Introduction -- II. Oviductal Transport -- III. Motility Modulation -- IV. Gamete Adhesion -- V. Acrosome Reaction -- VI. Egg Plasma Membrane Interactions and Egg Activation -- References -- Chapter 7. The JNK Family of MAP Kinases: Regulation and Function -- I. Introduction -- II. Regulation of c-Jun Expression and Activity -- III. Phosphorylation of the c-Jun Amino-Terminal Sites by JNK -- IV. Signal Transduction Pathways Leading to Activation of JNK and Other MAP Kinases -- V. Other Substrates for the JNKs -- VI. Biological Functions of JNK and Other MAP Kinase Pathways -- VII. Conclusions and Future Considerations -- References -- Chapter 8. PPARα: Tempting Fate with Fat -- I. PPARα as a Ligand-Activated Transcription Factor -- II. Lipid Homeostasis: How Complex Can It Be? -- III. PPARα Expression during Development and Adulthood -- IV. PPARα and Its Activators: Open Relationships? -- V. PPARα Ligands -- VI. PPARα Functions -- VII. Conclusion -- References -- Chapter 9. Molecular Mechanisms of Neuronal Survival and Apoptosis -- I. The Neurotrophic Theory -- II. Apoptosis-A Means of Neuronal Death -- III. Activity, Intracellular Calcium, and Survival -- IV. The Calcium Set-Point Hypothesis -- V. Mechanisms of Survival: Neurotrophin Receptors and Second Messengers -- VI. The Ras-MAPK Pathway -- VII. The Phosphatidylinositide-3'-OH Kinase/Akt Pathway -- VIII. Protein Kinase C -- IX. Neurotrophin-Dependent Pathway Cross-Talk -- X. Calcium-Dependent Kinase Pathways -- XI. Interaction of Calcium and Neurotrophin Signaling in Survival -- XII. Mechanisms of Death -- XIII. Upstream Events in Neuronal Death and p75 -- XIV. Death and Second Messengers: Ceramide and JNK/p38 -- XV. Signal Integration: The Balance between Life and Death.
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XVI. Caspases and the Bcl-2 Family -- XVII. Cell-Extrinsic Signaling Meets Cell-Intrinsic Survival and Death Mechanisms -- XVIII. Frontiers in Neuronal Survival and Death -- References -- Chapter 10. Nuclear Orphan Receptors: The Search for Novel Ligands and Signaling Pathways -- I. Introduction -- II. Discovery of Orphan Receptor Ligands -- III. Orphan Receptors That Function as RXR Heterodimers -- IV. Orphan Receptors That Function Independently of Dimerization with RXR -- V. Summary and Perspective -- References -- Index.
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