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  • 1
    ISSN: 0378-4363
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 94 Kindern mit akuter Hepatitis im Alter von zwei bis 14 Jahren wurde bei Einweisung in das Embaba Fever Hospital in Kairo, Ägypten, im Zeitraum von Januar bis April 1983 eine ätiologische Abklärung mittels Seromarkern für Hepatitis A, B und D vorgenommen. Bei 4% der Kinder wurde eine Hepatitis A, bei 33% eine Hepatitis B, bei 10% eine akute Hepatitis bei HBsAg-Trägerstatus, bei 2% eine Doppelinfektion mit HAV und HBV und bei 50% eine Non-A, Non-B-Hepatitis diagnostiziert. 96% der Kinder hatten eine Hepatitis A durchgemacht. 17% (fünf der 29 getesteten) Kinder mit akuter Hepatitis B wiesen Anti-delta-Antikörper auf. 15% (sechs von 40) HBsAg-positive Kinder waren HBeAg positiv. Bei zwei Patienten fanden sich gleichzeitig HBsAg und anti-HBs. Klinische, epidemiologische und biochemische Befunde wurden differential-diagnostisch ausgewertet, sie trugen jedoch nicht zu einer Differenzierung zwischen Hepatitis B und NANB bei. Bei HBV-Infektionen waren Buben häufiger betroffen. 58% der Kinder mit HBV- und 70% der Kinder mit NANB-Virus-Infektionen wiesen keine Risikofaktoren auf. 42% der übrigen mit HBV und 30% der mit NANB-Viren infizierten Kinder hatten Injektionen oder einen chirurgischen Eingriff erhalten, in keinem Fall war eine Bluttransfusion erfolgt oder Kontakt mit einem Hepatitisfall bekannt.
    Notes: Summary Seromarkers for hepatitis A, B and D were used to determine the cause of acute hepatitis in 94 children (age 2 to 14 years) propsectively studied when they were admitted to Embaba Fever Hospital in Cairo, Egypt, between January and April 1983. The diagnoses were: hepatitis A (4%), hepatitis B (33%), acute hepatitis in HBsAg carriers (10%), dual infections with A and B (2%), and hepatitis non-A, non-B (NANB) (50%). Past hepatitis A was diagnosed in 96%. Among acute hepatitis B infections, 17% (5 of 29 tested) had anti-delta antibody; of HBsAg positive persons, 15% (6 of 40) were HBeAg positive. Two patients had simultaneous presence of HBsAg and anti-HBs. For differential diagnosis, clinical, epidemiological, and biochemical findings were evaluated but did not distinguish hepatitis B from NANB hepatitis. Males predominated for HBV infections. No risk factors were found for 58% of HBV and 70% of NANB infections; of the remaining patients, 42% percent of HBV and 30% of NANB infections were associated with injections or surgery but none with transfusion or known contact with hepatitis cases.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 29 (1991), S. 989-999 
    ISSN: 0887-6266
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Interaction of high-pressure CO2 gas with a silicone elastomer, and to a lesser extent, with a nitrile rubber and a PTFE have been investigated. Sorptive dilations of the polymers were measured with the help of custom-made piezoelectric ultrasonic transducers under gas pressures of up to ca. 22 MPa at 42°C. The gas mass sorption was determined by a vibrating reed probe. For the silicone elastomer system the dilation isotherm mimics the sorption isotherm. The partial molar volume (PMV) of the absorbed CO2 gas in the silicone elastomer has been computed. A significant drop in the PMV value is observed when the CO2 gas becomes supercritical. In the transition region, the transmission of ultrasonic signals through the specimen indicated the formation of discrete small (estimated as about 60 μm in diameter) high density zones of CO2 in the rubber matrix. The plasticization effects of the absorbed high pressure CO2 gas have been identified from the interpretation of the changes in the acoustic longitudinal modulus obtained from ultrasonic transmission measurements. The effects of rapid gas decompression on the structural integrity of the various polymers have also been determined. Significant inflation of certain specimens occur toward the latter stages of the decompression cycle. The initiation and development of internal cracks or bubbles was followed by monitoring the ultrasonic signal attenuation.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 30 (1992), S. 959-969 
    ISSN: 0887-6266
    Keywords: composites of silicone elastomer and glass blends, interfacial quality and sorption of gas in ; sorption of gas in glass bead filled silicone elastomer, interfacial quality and dilation ; interfacial quality and gas sorption in silicone elastomer composites ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: In elastomers the crosslink density, the presence of filler particles, and the volumetric confinement toward sorptive dilation can influence the extent of gas mass uptake. In this study the effects of filler particles on the high-pressure gas mass sorption and the volumetric dilation of a silicone elastomer matrix has been investigated. Glass beads, ca. 30 μm radii, with different surface treatments were incorporated as inclusions in various specimens at relatively low concentrations of ca. 10% by volume. The high-pressure gases used were N2 and CO2 up to a maximum ambient pressure of ca. 25 MPa at ca. 20°C and 42°C, respectively. The gas mass sorption was determined by a vibrating reed technique. The sorptive dilation was measured by an ultrasonic transducer operating as a displacement probe. In certain systems the absorbed CO2 gas was able to disrupt the internal interfaces. This led to an increased gas mass uptake in the corrupted specimen. The N2 gas did not affect the interfacial bonds. The amount of penetrant uptake was found generally to be reduced when the internal interfaces were not disrupted. The presence of various internal interfaces restrained the sorptive dilation of the elastomeric matrix. These hindrances to the natural sorptive dilation of the elastomer network suppressed the extent of the gas sorption process. This effect has also been investigated separately in detail using model ‘poker chip’ type of specimens of various aspect ratios. The sorptive dilational characteristics have been correlated with the mechanical properties of similar specimens. The influence of an almost complete volumetric confinement on the gas sorption capacity of the silicone elastomer specimen has also been studied. © 1992 John Wiley & Sons, Inc.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2012-10-16
    Print ISSN: 0003-4819
    Electronic ISSN: 1539-3704
    Topics: Medicine
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  • 6
    Publication Date: 2014-06-10
    Keywords: Other diagnostic testing
    Electronic ISSN: 1524-4539
    Topics: Medicine
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  • 7
    Publication Date: 2015-06-18
    Description: The Malaysian Cohort study was initiated in 2005 by the Malaysian government. The top-down approach to this population-based cohort study ensured the allocation of sufficient funding for the project which aimed to recruit 100 000 individuals aged 35–70 years. Participants were recruited from rural and urban areas as well as from various socioeconomic groups. The main objectives of the study were to identify risk factors, to study gene-environment interaction and to discover biomarkers for the early detection of cancers and other diseases. At recruitment, a questionnaire-based interview was conducted, biophysical measurements were performed and biospecimens were collected, processed and stored. Baseline investigations included fasting blood sugar, fasting lipid profile, renal profile and full blood count. From April 2006 to the end of September 2012 we recruited a total of 106 527participants. The baseline prevalence data showed 16.6% participants with diabetes, 46.5% with hypertension, 44.9% with hypercholesterolaemia and 17.7% with obesity. The follow-up phase commenced in June 2013. This is the most comprehensive and biggest cohort study in Malaysia, and has become a valuable resource for epidemiological and biological research. For information on collaboration and also data access, investigators can contact the project leader at ( rahmanj@ppukm.ukm.edu.my ).
    Print ISSN: 0300-5771
    Electronic ISSN: 1464-3685
    Topics: Medicine
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  • 8
    Publication Date: 2016-07-06
    Description: Anna Kuta, Yaopan Mao, Tina Martin, Catia Ferreira de Sousa, Danielle Whiting, Sana Zakaria, Ivan Crespo-Enriquez, Philippa Evans, Bartosz Balczerski, Baljinder Mankoo, Kenneth D. Irvine, and Philippa H. Francis-West The protocadherins Fat4 and Dchs1 act as a receptor-ligand pair to regulate many developmental processes in mice and humans, including development of the vertebrae. Based on conservation of function between Drosophila and mammals, Fat4-Dchs1 signalling has been proposed to regulate planar cell polarity (PCP) and activity of the Hippo effectors Yap and Taz, which regulate cell proliferation, survival and differentiation. There is strong evidence for Fat regulation of PCP in mammals but the link with the Hippo pathway is unclear. In Fat4 –/– and Dchs1 –/– mice, many vertebrae are split along the midline and fused across the anterior-posterior axis, suggesting that these defects might arise due to altered cell polarity and/or changes in cell proliferation/differentiation. We show that the somite and sclerotome are specified appropriately, the transcriptional network that drives early chondrogenesis is intact, and that cell polarity within the sclerotome is unperturbed. We find that the key defect in Fat4 and Dchs1 mutant mice is decreased proliferation in the early sclerotome. This results in fewer chondrogenic cells within the developing vertebral body, which fail to condense appropriately along the midline. Analysis of Fat4;Yap and Fat4;Taz double mutants, and expression of their transcriptional target Ctgf, indicates that Fat4-Dchs1 regulates vertebral development independently of Yap and Taz. Thus, we have identified a new pathway crucial for the development of the vertebrae and our data indicate that novel mechanisms of Fat4-Dchs1 signalling have evolved to control cell proliferation within the developing vertebrae.
    Print ISSN: 0950-1991
    Electronic ISSN: 1477-9129
    Topics: Biology
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