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  • 1
    Electronic Resource
    Electronic Resource
    Locomotor activity in theTyr-1 mutant ofDrosophila melanogaster (1987)
    Springer
    Behavior genetics 17 (1987), S. 503-512 
    Details
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; locomotor activity ; stimulated activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract The genetics and neurochemistry of locomotor activity inDrosophila have received increasing attention, although no precise relationship has been formulated, and researchers have not always distinguished the various forms of activity. In the present research, using the dopamine-deficientTyr-1 mutant, we demonstrate that it is possible to operationally define and provide separate measures of spontaneous activity and reactivity and have also isolated a third, distinct, category of locomotor activity which we term “stimulated” activity. Our data indicate thatTyr-1 mutants do not differ from isogenic wild-type flies with respect to spontaneous activity or reactivity but that they do display significantly higher stimulated activity levels. It is suggested that low levels of dopamine inTyr-1 may result in increased stimulated activity rather than spontaneous activity as previous research has suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01073117
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    Paper (German National Licenses)
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    Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking (2016)
    Nature Research
    In:  Nature Biotechnology, 34 (8). pp. 828-837.
    Details
    Publication Date: 2019-02-01
    Description: The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data other than in published papers. Although mass spectrometry (MS) techniques are well-suited to high-throughput characterization of NP, there is a pressing need for an infrastructure to enable sharing and curation of data. We present Global Natural Products Social Molecular Networking (GNPS; http://gnps.ucsd.edu), an open-access knowledge base for community-wide organization and sharing of raw, processed or identified tandem mass (MS/MS) spectrometry data. In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations. Data-driven social-networking should facilitate identification of spectra and foster collaborations. We also introduce the concept of 'living data' through continuous reanalysis of deposited data.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1038/nbt.3597
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    OceanRep: Article in a Scientific Journal - peer-reviewed
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