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  • 1
    Electronic Resource
    Electronic Resource
    Epstein–Barr virus in gastric carcinomas with lymphoid stroma (2000)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 37 (2000), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: AimsTo clarify the relationship between the Epstein–Barr virus (EBV) and gastric carcinoma with lymphoid stroma (GCLS) in Koreans, and to characterize the EBV-positive GCLS.Methods and resultsEBV infection was examined using EBER in-situ hybridization and polymerase chain reaction in 45 cases of GCLS among Koreans, and in 292 consecutive cases of gastric carcinomas without lymphoid stroma (non-GCLS) as controls. EBV infection was found in 30 tumours (67%) of GCLS and 10 tumours (3.4%) of non-GCLS (P 〈 0.05). EBV-positive GCLS was more prevalent in males, poorly differentiated histological type and diffuse type in Lauren's classification, and tended to be located more in the middle third of the stomach than EBV-negative GCLS (P 〈 0.05). p53 overexpression was observed in 22% of GCLS (17% of EBV-positive GCLS and 33% of EBV-negative GCLS), and 34% of non-GCLS (EBV-positive GCLS vs. non-GCLS: P = 0.056). The survival of the patient with GCLS was not correlated with EBV infection or p53 immunoexpression (follow-up period: 11–97 months).ConclusionsGCLS in Koreans is strongly associated with EBV infection. The prognosis in GCLS is not dependent upon either the status of EBV infection or the status of p53 immunoexpression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2000.01014.x
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  • 2
    Electronic Resource
    Electronic Resource
    Alteration of E-cadherin-mediated adhesion protein is common, but microsatellite instability is uncommon in young age gastric cancers (2003)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 42 (2003), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  Gastric adenocarcinoma in young patients has been considered to differ in many ways from gastric carcinoma in older patients. This study was designed to determine the clinicopathological features and molecular mechanisms.Methods and results:  Based on 4123 patients of gastric cancer in Seoul National University Hospital, 135 patients (3.3%) were chosen by the age of 30 years or younger. Expression of E-cadherin, β-catenin, p53 and Epstein–Barr virus (EBV) was analysed using the tissue array method in formalin-fixed paraffin-embedded specimens and microsatellite instability (MSI) was determined. As a control, 320 cases of older patients were compared. Gastric adenocarcinoma of young patients revealed significant female predominance, type IV gross type, proximal location, diffuse type and frequent lymph node metastasis. In-situ hybridization for EBV showed higher positivity in young patients (9/78, 11.5%) than in older ones, but not statistically significant. In EBV+ cases, p53 over-expression was significantly higher in young patients than older patients (P 〈 0.05). Alteration of E-cadherin or β-catenin was significantly higher in younger patients than in older patients (P 〈 0.05). Overall survival was significantly poorer in younger patients than older ones. The frequency of MSI was rare (1.3%, P 〈 0.05) in young patients compared with older patients (9.3%).Conclusions:  These data indicate that gastric adenocarcinoma of young patients has a poor prognosis, possesses aggressive histopathological features, exhibits reduced expression of E-cadherin and β-catenin, and demonstrates lower MSI than tumours in older patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2003.01546.x
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  • 3
    Electronic Resource
    Electronic Resource
    Neutron powder diffraction study of phase separation in La"2CuO"4"+"δ
    Amsterdam : Elsevier
    Physica C: Superconductivity and its applications 235-240 (1994), S. 841-842 
    Details
    ISSN: 0921-4534
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-4534(94)91645-4
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  • 4
    Electronic Resource
    Electronic Resource
    Transformation robust experimental design with application to some problems in chemistry
    Amsterdam : Elsevier
    Chemometrics and Intelligent Laboratory Systems 10 (1991), S. 261-270 
    Details
    ISSN: 0169-7439
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0169-7439(91)80057-W
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  • 5
    Electronic Resource
    Electronic Resource
    α-Fetoprotein-producing gastric carcinoma presenting focal hepatoid differentiation in metastatic lymph nodes (1998)
    Springer
    Virchows Archiv 432 (1998), S. 85-87 
    Details
    ISSN: 1432-2307
    Keywords: Key words Hepatoid adenocarcinoma ; AFP-producing gastric carcinoma ; Stomach ; Alpha-fetoprotein ; Metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Hepatoid adenocarcinoma (HA) is a rare variant of adenocarcinoma of the stomach, which is clinically characterized by increased level of serum α-fetoprotein(AFP) and poor prognosis. Microscopic findings include both adenocarcinomatous and hepatoid elements. A case of gastric adenocarcinoma with focal hepatoid differentiation confined within the metastatic lymph nodes occurred in a 55-year-old woman, who developed an advanced gastric carcinoma composed entirely of a typical papillo-tubular adenocarcinoma. Metastatic tumors were present in 8 of 13 perigastric lymph nodes, and 3 of these showed medullary and trabecular tumour growth reminiscent of hepatocellular carcinoma with immunohistochemical positivity for AFP. Preoperative serum AFP was 630 ng/ml and dropped to 76 ng/ml 2 weeks after the operation. Microscopic and immunohistochemical studies on the entire primary tumour tissue failed to demonstrate a focus of hepatoid or an AFP-positive area. This suggests that elevation of serum AFP may be reflected by focal hepatoid differentiation only in the metastatic lymph nodes, requiring extensive evaluation of the metastatic tumour in regional lymph nodes in the case of AFP-producing gastric carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050138
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  • 6
    Electronic Resource
    Electronic Resource
    p53 Mutation and overexpression in hepatocellular carcinoma and dysplastic nodules in the liver (1998)
    Springer
    Virchows Archiv 432 (1998), S. 27-32 
    Details
    ISSN: 1432-2307
    Keywords: Key words p53 Mutation ; Overexpression ; Dysplastic nodule ; Hepatocellular carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In hepatocarcinogenesis, both de novo and multistep pathways have been suggested and in the latter a dysplastic nodule is the proposed precancerous lesion. In this study, we tried to ascertain whether or not the p53 gene is altered in low-grade/high-grade dysplastic nodules (LDN/HDN) and to determine the role of p53 alteration in multistep hepatocarcinogenesis. Eight hepatocellular carcinomas (HCCs), 9 HDNs, 17 LDNs and 25 cirrhotic nodules (LCs) were examined by polymerase chain reaction-single strand conformation polymorphism/direct sequencing and immunohistochemical staining for p53. Four of the 8 HCCs (50%) revealed p53 overexpression and 2 (25%) had missense mutations. Four of the 9 HDNs (44%) showed weak and/or focal p53 overexpression but none had mutation in the exons examined. Neither p53 overexpression nor mutation was found in 17 LDNs and 25 LCs. These results suggest that p53 mutation might be an unusual event in precancerous lesions of multistep hepatocarcinogenesis (DN-HCC sequence) and may play a less crucial part than in colorectal carcinogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050130
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  • 7
    Electronic Resource
    Electronic Resource
    Cystic peripheral cholangiocarcinoma: sonography and CT (1995)
    Springer
    Abdominal imaging 20 (1995), S. 131-132 
    Details
    ISSN: 1432-0509
    Keywords: Liver, cholangiocarcinoama ; Liver, US studies ; Liver, CT studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of cystic peripheral cholangiocarcinoma is presented. Both sonography and computed tomography (CT) demonstrated a large intrahepatic cystic neoplasm containing an enhancing solid portion. Despite the very rare incidence of this tumor, we believe that cystic degeneration of peripheral cholangiocarcinoma should be considered with these radiologic findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201520
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  • 8
    Electronic Resource
    Electronic Resource
    Heterotopic pancreas of the stomach: CT findings correlated with pathologic findings in six patients (2000)
    Springer
    Abdominal imaging 25 (2000), S. 119-123 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Pancreas, ectopic—Stomach, diseases—Stomach, cysts—Stomach, CT.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The purpose of this study was to characterize the computed tomographic (CT) findings of heterotopic pancreas of the stomach. Methods: CT scans of six surgically proven cases of heterotopic pancreas of the stomach were reviewed. Three were dynamic spiral CT scans, with both arterial dominant and late phase scans. In other three, both unenhanced and contrast-enhanced scans were obtained by using conventional techniques. Particular attention was given to the enhancement of the heterotopic pancreas. Pathologic and surgical findings were correlated with CT findings. Results: The locations were in the gastric antrum in five cases and in the mid-body in one. Size ranged from 1 cm to 3 cm (mean = 2.1 cm). Three cases showed homogeneous, strong enhancement similar to the pancreas and consisted mainly of pancreatic acini with the same histologic features as the normal pancreas. Two cases showed poor enhancement and consisted mainly of ducts and hypertrophied muscle; pancreatic acini were a minor component. In one case appearing as a cystic lesion on CT, a pseudocyst was found with many ducts and some nests of pancreatic acini. Conclusions: Heterotopic pancreas of the stomach showed a diverse spectrum of CT findings. Good understanding of these CT findings may be helpful in making a correct diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619910028
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  • 9
    Electronic Resource
    Electronic Resource
    Intraductal mucosal-spreading mucin-producing peripheral cholangiocarcinoma of the liver (2000)
    Springer
    Abdominal imaging 25 (2000), S. 89-92 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Liver CT—Bile duct neoplasm—Peripheral cholangiocarcinoma—Cystic tumor of liver—Bile duct neoplasm, ERCP.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The computed tomographic (CT) appearance of a case of intraductal mucosal-spreading mucin-producing peripheral cholangiocarcinoma of the liver is described in a patient presenting with acute pericardial tamponade due to rupture of the cystically dilated left intrahepatic ducts by mucin hypersecretion. CT showed cystic and tubular dilatation of the intrahepatic ducts of the left and caudate lobes, but there was no grossly visible tumor mass. Pathology showed a single layer of tall columnar tumor cells with short intraluminal papillary projections lining each bile duct; the ducts were markedly dilated because of excessive mucin secretion. There was no gross tumor mass in the bile ducts. The tumor spread diffusely and contiguously along the intrahepatic bile ducts, with minimal invasion to the bile duct wall. To our knowledge, there has been no report about mucosal-spreading peripheral cholangiocarcinoma of the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/s002619910018
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  • 10
    Electronic Resource
    Electronic Resource
    Combined hepatocellular and cholangiocarcinoma of the liver: Sonography, CT, Angiography, and Iodized-Oil CT with pathologic correlation (1994)
    Springer
    Abdominal imaging 19 (1994), S. 43-46 
    Details
    ISSN: 1432-0509
    Keywords: Liver, neoplasms ; Sonography ; Angiography ; Computed tomography ; Oily contrast media
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the characteristics of combined hepatocellular and cholangiocarcinoma of the liver by imaging techniques, six patients (five male and one female), aged 46–60 years, with proved combined tumors were selected for this study from the review of 500 resected specimens of liver tumors. Images obtained from sonography, computed tomography (CT), angiography, and CT after intraarterial injection of iodized oil (iodized-oil CT) were retrospectively reviewed and correlated with the appearance of pathologic specimens. Sonographic findings were round or ovoid hypoechoic masses with central hyperechoic area (target appearance) in all patients. On CT scans, tumors were relatively well-defined low- and/or iso-attenuation masses in all patients. Angiography showed hypovascular masses in five patients. In one patient, the tumor appeared as a hypovascular mass with a central hypervascular area. On iodized-oil CT scans, all patients showed partial retention of iodized oil in tumors. Echogenicity in tumors at sonography or attenuation in tumors at CT could not be correlated with histologic difference in tumors at pathologic specimens. However, the hypervascular area at angiography and the compact retention areas of iodized oil at iodized-oil CT corresponded to portions of hepatocellular carcinoma within the combined tumor. On the basis of our results, imaging features, including target appearance at sonography, hypovascular mass with central hypervascular portions at angiography, and partial retention of iodized oil in tumors at iodized-oil CT, might be helpful in making accurate diagnosis of these rare tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02165860
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