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  • 1
    Digitale Medien
    Digitale Medien
    Pregnancy in women with von Willebrand's disease or factor XI deficiency (1998)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 105 (1998), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objective To assess the obstetric outcome in women with von Willebrand's disease or factor XI deficiency.Setting Haemophilia Centre and Haemostasis Unit, The Royal Free Hospital.Population Women with von Willebrand's disease (n= 31) and with factor XI deficiency (n= 11) registered at the Royal Free Hospital Haemophilia Centre who had had a pregnancy within the previous 17 years (1980–1996), including 84 in women with von Willebrand's disease and 28 in women with factor XI deficiency.Methods Women were interviewed and details of the obstetric history were obtained. The records of the Haemophilia Centre and the women's maternity records were also reviewed.Results Threatened miscarriage occurred in 33% and 14% of pregnancies with von Willebrand's disease and factor XI deficiency, respectively. Excluding recurrent miscarriages, 14/68 (21%) of pregnancies with von Willebrand's disease and one pregnancy with factor XI deficiency miscarried spontaneously. There was an increased incidence of primary and secondary post-abortal bleeding complications. Factor VIJI and von Willebrand factor antigen and activity levels increased significantly in pregnancy in all women apart from those with severe von Willebrand's disease. Factor XI, however, did not show any significant change. No neonatal haemorrhagic complications in association with the birth process were reported, although ventouse and difficult forceps deliveries were avoided. Extensive perineal bruising and haematoma was reported in three women with von Willebrand's disease; two of these were associated with forceps delivery. The incidence of primary postpartum haemorrhage was 185% in von Willebrand's disease and 16% in factor XI deficiency. Blood transfusion was required in six cases of von Willebrand's disease and two cases of factor XI deficiency. Ten of fourteen instances of primary postpartum haemorrhage occurred when maternal factor levels were 〈 50 IU/dL with no prophylactic treatment for labour. The incidence of secondary postpartum haemorrhage was 20% in von Willebrand's disease and 24% in factor XI deficiency. None of the women who had prophylactic treatment during labour or the puerperium suffered any significant bleeding complications. There were three neonatal bleeding complications.Conclusion Pregnancy, labour and the puerperium are associated with significant bleeding problems in women with von Willebrand's disease or factor XI deficiency, but these are largely preventable. Specialist obstetric care in close liaison with the haemophilia centre is essential to minimise maternal deficiency. and neonatal complications.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1998.tb10093.x
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  • 2
    Digitale Medien
    Digitale Medien
    von Willebrand disease in women with menorrhagia: a systematic review (2004)
    Oxford, UK and Malden, USA : Blackwell Science Ltd
    BJOG 111 (2004), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objective  To determine the prevalence of von Willebrand disease in women presenting with menorrhagia.Design  Systematic review of studies evaluating the prevalence of von Willebrand disease in women with menorrhagia.Setting  Hospital outpatient clinics (mainly gynaecological) and population surveys.Population  Women presenting with menorrhagia.Methods  Relevant studies were extracted from MEDLINE search, bibliographies of identified articles and published proceedings of meetings and conferences.Main outcome measures  Number of women with von Willebrand disease.Results  Eleven studies were included, totalling 988 women with menorrhagia. One hundred and thirty-one women were diagnosed to have von Willebrand disease with prevalences in individual studies ranging from 5% to 24%. The overall prevalence was 13% (95% CI 11–15.6%). The prevalence was higher in the European studies—18% (95% CI 15–23%) compared with that in North American studies—10% (95% CI 7.5–13%). This difference (P= 0.007) is likely to be the result of differences in the studies, which include method of recruitment of study population, method of assessing menstrual blood loss ethnic composition of study population, criteria for diagnosis and use of race- and ABO blood group-specific values for von Willebrand factor.Conclusions  The prevalence of von Willebrand disease is increased in women with menorrhagia and is the underlying cause in a small but significant group of women with menorrhagia across the world. Testing for this disorder should be considered when investigating women with menorrhagia, especially those of Caucasian origin, those with no obvious pelvic pathology or with additional bleeding symptoms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.2004.00176.x
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  • 3
    Digitale Medien
    Digitale Medien
    Prophylaxis for Pneumocystis carinii pneumonia: its impact on the natural history of HIV infection in men with haemophilia (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Haemophilia 1 (1995), S. 0 
    Details
    ISSN: 1365-2516
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: It has been suggested that the range of AIDS-defining conditions witnessed in patients with HIV infection has changed since the early years of the HIV epidemic. In this paper we consider the range of AIDS-defining conditions in a cohort of 111 HIV-positive men with haemophilia registered at the Royal Free Hospital Haemophilia Centre. In particular we assess whether the incidence of Pneumocystis carinii pneumonia (PCP) has changed over time. The men were all infected between 1979 and 1985 after treatment with infected blood products and have now been followed prospectively for up to 13 years from HIV seroconversion. By the end of 1992, 44/111 patients had developed AIDS. Of the 44 men, 18 (41%) presented with PCP as their first AIDS-defining condition (ADC), mainly before the initiation of primary prophylaxis in 1989. The remaining 26 patients presented with a range of conditions as their first ADC, but there were no more than four cases in any one disease category. It is estimated that patients suffer from 0.7 further ADCs per year after being diagnosed with AIDS. After taking account of the increased levels of immuno-suppression in the cohort with time, it appears that the incidence of PCP, both as the first ADC or as any ADC, has declined since the introduction of primary prophylaxis for the disease in 1989. However, non-compliance with prophylaxis for PCP appears to have played a major role in the continuing occurrence of PCP since 1988. Improvements in compliance with therapy should result in a further reduction in the incidence of PCP both as a first ADC and as any ADC.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2516.1995.tb00038.x
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  • 4
    Digitale Medien
    Digitale Medien
    Antiviral therapy (1995)
    [s.l.] : Nature Publishing Group
    Nature 375 (1995), S. 195-195 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] SIR - Ho et all state that "patients with lower initial CD4 cell counts had more prominent rises" (in CD4 count during treatment). This conclusion was substantiated with an analysis showing a correlation coefficient of -0.57 (P〈0.01) for the association between ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/375195a0
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  • 5
    Digitale Medien
    Digitale Medien
    Targeting C-reactive protein for the treatment of cardiovascular disease (2006)
    [s.l.] : Nature Publishing Group
    Nature 440 (2006), S. 1217-1221 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivors of the acute event, larger non-functional ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/nature04672
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  • 6
    Digitale Medien
    Digitale Medien
    Viral burden in HIV infection (1994)
    [s.l.] : Nature Publishing Group
    Nature 367 (1994), S. 124-124 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] SIR - McLean and Michie1 and Garry and Fermin2 argue in Scientific Correspondence that the direct cytopathic effects of the virus could well be the main cause of Kaplan Meier estimates of the percent of haemophilic individuals having a CD4 lymphocyte count below 250 mrrr3 (a) or 100 mm"3 (b) ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/367124a0
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