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  • 1
    Electronic Resource
    Electronic Resource
    Nutritional management of children with chronic renal failure (1987)
    Springer
    Pediatric nephrology 1 (1987), S. 195-211 
    Details
    ISSN: 1432-198X
    Keywords: Chronic renal failure ; Serum creatinine ; Nutrition ; Nutritional assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Current information on the adaptations to progressive loss of renal function is presented. The assessment of renal function in infants and children using serum creatinine concentration and its derivatives is considered as are various methods for assessment of growth. Children with creatinine clearances less than 50% of normal, who do not have uremic symptoms (and who are not on dialysis), should be ingesting diets providing close to 100% of the RDA for calories with 8% of the calories as protein. Recommendations for nutritional management of children on chronic peritoneal dialysis are also presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00849294
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  • 2
    Electronic Resource
    Electronic Resource
    Posterior urethral valves in patients with Down syndrome (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 143-146 
    Details
    ISSN: 1432-198X
    Keywords: Obstructive uropathy ; Renal failure ; Hydronephrosis ; Chromosomal ; Urethra
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Renal and urological anomalies in Down syndrome (DS) have received little attention compared with the nephrourological findings described in other chromosomal abnormalities. Renal hypoplasia, hydroureteronephrosis, ureterovesical and ureteropelvic junction obstruction, and vesicoureteral reflux, but not posterior urethral valves, have been associated with DS. We report the occurrence of posterior urethral valves in three male infants with DS at a single institution. All had multiple urological procedures for correction or palliation of obstruction. Children with DS may have an increased risk for developing posterior urethral valves and obstructive uropathy. Furthermore, they may also develop chronic renal failure secondary to posterior urethral valves. Therefore, we suggests that infants with DS be screened with ultrasonography for renal and urological abnormalities early in life and, if abnormal, a contrast voiding cystourethrogram be performed to rule out posterior urethral valves or other bladder or urethral abnormalities. A review of the renal and urological anomalies in DS reported in the literature since 1960 is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00862055
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  • 3
    Electronic Resource
    Electronic Resource
    Posterior urethral valves in patients with Down syndrome (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 143-146 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Obstructive uropathy ; Renal failure ; Hydronephrosis ; Chromosomal ; Urethra
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Renal and urological anomalies in Down syndrome (DS) have received little attention compared with the nephrourological findings described in other chromosomal abnormalities. Renal hypoplasia, hydroureteronephrosis, ureterovesical and ureteropelvic junction obstruction, and vesicoureteral reflux, but not posterior urethral valves, have been associated with DS. We report the occurrence of posterior urethral valves in three male infants with DS at a single institution. All had multiple urological procedures for correction or palliation of obstruction. Children with DS may have an increased risk for developing posterior urethral valves and obstructive uropathy. Furthermore, they may also develop chronic renal failure secondary to posterior urethral valves. Therefore, we suggests that infants with DS be screened with ultrasonography for renal and urological abnormalities early in life and, if abnormal, a contrast voiding cystourethrogram be performed to rule out posterior urethral valves or other bladder or urethral abnormalities. A review of the renal and urological anomalies in DS reported in the literature since 1960 is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00862055
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  • 4
    Electronic Resource
    Electronic Resource
    Growth hormone and insulin-like growth factor-I and mesangial matrix in uremic rats (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 299-303 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Growth hormone ; Insulin-like growth factor-1 ; Uremia ; Mesangial matrix ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Combined growth hormone (GH) and insulin-like growth factor-I (IGF-I) therapy has been advocated for clinical use to minimize the diabetogenic effect of GH and enhance their anabolic effects. However, GH has been shown to accelerate the development of glomerular sclerosis in experimental animals and IGF-I mediates the renal effects of GH. The purpose of this study was therefore to examine morphometrically the effects of GH (1 mg intraperitoneally three times a week), IGF-I (50 μg/kg body weight subcutaneously twice a day), and combined GH/IGF-I treatments in vivo on mesangial matrix at 3 – 20 days after 5/6 nephrectomy in 140- to 150-g rats. There were no significant changes in growth and renal function after GH and/or IGF-I treatment. The effects of GH and IGF-I on glomerular size were additive, which were more prominent in juxtamedullary glomeruli. GH induced proportional increases in mesangial area (MA) and glomerular area (GA), whereas IGF-I induced a similar increase in GA without a corresponding change in MA. When compared with GH treatment alone, combined GH/IGF-I treatment resulted in a lesser degree of mesangial expansion despite an enhanced glomerular size. While additional studies are needed to examine the long-term effects of these findings, our results suggest a potentially beneficial effect of combined GH/IGF-I therapy during uremia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00866765
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  • 5
    Electronic Resource
    Electronic Resource
    Growth preservation after brief growth hormone therapy in chronic renal insufficiency (1997)
    Springer
    Pediatric nephrology 11 (1997), S. 82-83 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Recombinant human growth hormone ; Growth ; Chronic renal insufficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A boy of 3 years 8 months with short stature due to chronic renal insufficiency was treated with recombinant human growth hormone (rhGH) for 20 months. Catch-up growth was achieved and the improvement of the height standard deviation score was sustained throughout an additional 4 years of follow-up without further rhGH therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050238
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  • 6
    Electronic Resource
    Electronic Resource
    Ask the expert (1989)
    Springer
    Pediatric nephrology 3 (1989), S. 316-316 
    Details
    ISSN: 1432-198X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00858541
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  • 7
    Electronic Resource
    Electronic Resource
    Recombinant human growth hormone treatment of children following renal transplantation (1991)
    Springer
    Pediatric nephrology 5 (1991), S. 147-151 
    Details
    ISSN: 1432-198X
    Keywords: Recombinant human growth hormone ; Growth retardation ; Renal allograft recipients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nine growth-retarded renal allograft recipients received either thrice weekly or daily subcutaneous recombinant human growth hormone (rhGH) for 6–30 months. The annualized growth velocity for the initial year of rhGH treatment was significantly greater than that of the preceding year (2.5±2.1 vs 5.7±2.7;P〈0.0001). There was no advancement in bone age greater than the increase in chronological age, no significant increase in the mean fasting serum glucose or insulin levels, nor significant decrease in the calculated creatinine clearance following rhGH treatment. However, two patients experienced rejection episodes following rhGH treatment indicating the potiental adverse consequences of the treatment on allograft function. This will require further delineation in prospective controlled studies. The serum insulin-like growth factor-1 levels significantly increased at 6 months (P〈0.009) and 12 months (P〈0.002) following rhGH treatment compared with baseline values. These preliminary data indicate that rhGH treatment may be effective in improving the growth velocity of growth-retarded renal allograft recipients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00852873
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  • 8
    Electronic Resource
    Electronic Resource
    Acquired cystic kidney disease in children undergoing long-term dialysis (1988)
    Springer
    Pediatric nephrology 2 (1988), S. 8-11 
    Details
    ISSN: 1432-198X
    Keywords: Acquired cystic kidney disease ; Magnetic resonance imaging ; Ultrasonography ; Children ; Peritoneal dialysis ; Hemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acquired cystic kidney disease (ACKD) occurs in adult patients undergoing long-term dialysis. Early detection is important because clinically significant hematuria and malignancies are associated with ACKD. We evaluated by magnetic resonance imaging (MRI) and ultrasonography (US) the incidence of ACKD in 15 patients aged 7.3–21.6 years (mean 15.9 years) with non-cystic primary renal disease. Nine patients had been treated with peritoneal dialysis only, and 6 with both hemodialysis and peritoneal dialysis for 24–73 months (mean 37 months). Three patients (20%) had no cysts. In 5 patients (33%) with bilateral multiple cysts, the diagnosis of ACKD was made by MRI and US. In another 5 patients, solitary cysts were localized to one kidney by MRI, and in 2 patients solitary cysts were seen in both kidneys. This study documents that ACKD is not limited to older patients with end-stage renal disease. Early detection of these cysts can be accomplished by MRI and is warranted since 1 patient developed neoplastic tubular changes which can precede tumor formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870371
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  • 9
    Electronic Resource
    Electronic Resource
    IgG and IgA classes of anti-neutrophil cytoplasmic autoantibodies in a 13-year-old girl with recurrent Henoch-Schonlein purpura (1993)
    Springer
    Pediatric nephrology 7 (1993), S. 143-146 
    Details
    ISSN: 1432-198X
    Keywords: Anti-neutrophil cytoplasmic autoantibodies ; Henoch-Schonlein purpura ; Vasculitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe a 13-year-old girl with recurrent Henoch-Schonlein purpura whose symptoms were precipitated by upper respiratory tract infections. Her serum was positive for both IgG and IgA classes of anti-neutrophil cytoplasmic autoantibodies by immunofluorescence. The titers of both autoantibodies correlated with disease activity. The immunopathology underlying these findings is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00864379
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  • 10
    Electronic Resource
    Electronic Resource
    Carbohydrate metabolism in children receiving growth hormone for 5 years (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 261-263 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Carbohydrate metabolism ; Chronic renal insufficiency ; Growth hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Carbohydrate metabolism was evaluated by fasting and postprandial glucose, insulin, and hemoglobin (Hb)A1c levels in children with chronic renal insufficiency and various other growth disorders treated with growth hormone. Mean fasting and postprandial glucose remained unchanged throughout the 5-year study period in all four study groups. Median fasting insulin levels rose from low-normal levels into the normal range after 5 years of growth hormone. Average fasting insulin level after 5 years was 10 mU/l. Median postprandial insulin values also rose, yet remained within the normal range at the 5-year mark. Mean Hb A1c levels remained within low to middle end of the normal range in the patients with growth hormone deficiency, Turner syndrome, and idiopathic short stature. Mean Hb A1c levels at the 5 years were slightly elevated to 6.3% for the patients with chronic renal insufficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00866753
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