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  • 11
    Electronic Resource
    Electronic Resource
    In vivo estimation of renal volume using a rotating gamma camera for 99mTc-dimercaptosuccinic acid renal imaging (1984)
    Springer
    European journal of nuclear medicine 9 (1984), S. 168-172 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The in vivo renal volume was determined using SPECT for 99mTc-DMSA renal imaging. The total renal volume was derived by summing the DMSA distribution volumes of the transaxial slices in the whole kidney. In 20 healthy subjects the renal volume in the right kidney was 220 ml for men and 195.2 ml for women, while that in the left kidney was 213 ml for men and 193.7 ml for women. Differences in those values were not statistically significant. A good correlation was found between renal volumes in both kidneys and body surface area. In 106 kidneys including solitary and pathological kidneys, individual renal volume correlated well with individual DMSA renal uptake rate which demonstrates cortical functioning mass, depending on the cortical blood flow. Thus, SPECT enables an accurate noninvasive means of estimating in vivo functioning renal volume.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251465
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  • 12
    Electronic Resource
    Electronic Resource
    Technetium coordination state as a factor of stability in 99mTc-complexes used in hepatobiliary system: Comparative studies on 99mTc-complexes of pyridoxal with glutamate (Tc-PG) and isoleucine (Tc-PI) (1981)
    Springer
    European journal of nuclear medicine 6 (1981), S. 573-579 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Studies on 99mTc-Penicillamine (Tc-Pen) have given us some insight into the significance of the technetium coordination state in hepatobiliary clearance behavior. A 99mTc-complex of pyridoxal and glutamate (Tc-PG) prepared by Baker et al. (1975) using an autoclaving process or by a Sn-Resin kit method (Horiuchi 1981) was compared with a 99mTc-complex of pyridoxal and isoleucine (Tc-PI) prepared by the method of Kato and Hazue (1978) through an intermediate compound of stannous ion, at room temperature. Tc-PG and TcPI complexes analyzed by thin layer chromatography, sephadex column chromatography (G-15), octanol extraction, and ligand exchange reaction showed different chemical properties. Their biological evaluation also demonstrated great differences in biodistribution in mice, metabolic studies, protein binding, and rat bile excretion. Tc-PG was estimated as an hepatobiliary agent with strong metal-ligand binding, inert to ligand exchange reaction with Pen at physiological pH; the likely occurrence of technetium in a mononuclear or dinuclear state providing the great stability observed in its biological and in vivo behavior was compared with the relatively weaker binding observed in Tc-PI, a highly lipophilic complex of high liver partition but of low stability, denoting its different chemical characteristics. The technetium coordination state in radiopharmaceuticals is responsible for the integrity of the molecule while in the blood pool and its relevance in impaired liver uptake is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252672
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  • 13
    Electronic Resource
    Electronic Resource
    Visualization of skeletal muscle involvement of mycosis fungoides on 67Ga scintigraphy (1982)
    Springer
    European journal of nuclear medicine 7 (1982), S. 333-335 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intense accumulation of radioactivity during 67Ga-citrate scanning was observed in the leg of a patient with advanced mycosis fungoides after repeated radiotherapy and chemotherapy. Infiltration of the calf muscle by neoplastic lymphoid cells was confirmed at autopsy. Radionuclide visualization of an uncommon involvement of the skeletal muscle by the disease has not been previously reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253433
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  • 14
    Electronic Resource
    Electronic Resource
    Scintigraphic visualization of extraosseous xanthomatosis (1982)
    Springer
    European journal of nuclear medicine 7 (1982), S. 434-436 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A histologically proven case of extraosseous xanthomatosis is presented. Both Ga-67 citrate and Tc-99m-MDP imagings demonstrated tumor uptake of radiotracers. A second Ga-67 imaging taken after excisional biopsy of the left knee lesion revealed disappearance of the lesional uptake of the tracer seen on the preoperative Ga-67 scan. Radiotracer accumulation in extraosseous xanthomatosis has not been reported previously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256828
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  • 15
    Electronic Resource
    Electronic Resource
    Accumulation of 99mTc-methylene diphosphonate in a so-called conversion defect of the femoral neck (1981)
    Springer
    European journal of nuclear medicine 6 (1981), S. 421-423 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 99m-Tc-methylene diphosphonate (99mTc-MDP) was found to accumulate in one of the two radiolucent areas of the bilateral femoral neck, both of which were radiographically typical of the so-called conversion defects of the proximal femur, a type of normal roentgen variant. The mechanisms possibly involved in this previously unreported phenomenon are discussed in relation to the apparent discrepancy regarding radionuclide uptake by the two lesions of the same entity in one patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266434
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  • 16
    Electronic Resource
    Electronic Resource
    Segmental analysis of stress thallium myocardial emission tomography for localization of coronary artery disease (1984)
    Springer
    European journal of nuclear medicine 9 (1984), S. 99-105 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The value of stress thallium 201 myocardial emission computed tomography (ECT) in the assessment of coronary artery disease (CAD) was analyzed in 75 patients admitted for coronary arteriography. The ECT provided contiguous transaxial, short-axis, and long-axis sections of the myocardium and the myocardial images were divided into nine segments. The sensitivity and specificity in the diagnosis of CAD were 95% and 93%, respectively. Using selected segments, the ECT identified 97 of 111 (83%) major vessels involved: 89% for right coronary artery (RCA), 88% for left anterior descending (LAD), and 70% for left circumflex (LCx). Among the 75 cases, 35 underwent stress conventional planar imaging within 3 months. The planar imaging provided high sensitivity (90%) and specificity (100%) for the detection of CAD patients as well, but it showed lower sensitivity (57%, P〈0.001) in identifying individual vessels involved: 55% for RCA (P〈0.01), 70% for LAD, and 36% for LCx (P〈0.05). Stress ECT detected vessel involvement more in two-vessel disease (85%) and three-vessel disease (78%) than the planar imaging (50%: P〈0.05 and 44%: P〈0.01, respectively). Thus, segmental analysis of stress ECT yielded as high sensitivity and specificity in the diagnosis of CAD as the planar imaging. This can improve sensitivity in identifying individual vessels involved in deep myocardial regions, especially in those with multivessel disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253509
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  • 17
    Electronic Resource
    Electronic Resource
    Asynchronous filling in ischemic heart disease and hypertrophic cardiomyopathy (1986)
    Springer
    European journal of nuclear medicine 11 (1986), S. 421-427 
    Details
    ISSN: 1619-7089
    Keywords: Gated blood-pool study ; Higher-order harmonics ; Phase analysis ; Asynchronous filling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A multigated blood-pool study was performed to assess regional and global emptying and filling in 16 patients with hypertrophic cardiomyopathy (HCM), 43 patients with ischemic heart disease (IHD), and 14 controls. The regional volume curve was fitted using second-order harmonics in the Fourier series, while the global left-ventricular volume curve was fitted using third-order harmonics. As asynchronous indices, the standard deviations (SD) in distribution histograms of time to end-systole (TES), time to peak ejection (TPE), and time to peak filling (TPF) were obtained in the left ventricle. In patients with IHD, the TPF-SD was higher (14.4±11.3°) than the TES-SD (7.8±5.1°) and TPE-SD (8.1±5.9°), suggesting the presence of asynchronous filling. In patients with HCM, the TPF-SD was also higher (11.6±11.1°) than the TES-SD (3.5±2.4°) and TPE-SD (6.2±4.4°). The phase delay was localized in the anteroseptal or apical region in all 5 HCM patients with abnormal wall motion, while it corresponded with the region of abnormal wall motion in the patients with IHD. The TPF-SD was inversely correlated with the left-ventricular ejection fraction (r=-0.46), peak filling rate (r=-0.50), and the ratio of peak filling rate to peak ejection rate (r=-0.52), suggesting that asynchronous filling is related to global diastolic disturbance. We conclude that asynchronous filling is often present in patients with IHD and HCM, and that our technique can be used to obtain a quantitative assessment of regional asynchronous emptying and filling in these diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261003
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  • 18
    Electronic Resource
    Electronic Resource
    A new approach toward a pancreas-seeking zinc radiopharmaceutical (1986)
    Springer
    European journal of nuclear medicine 11 (1986), S. 488-493 
    Details
    ISSN: 1619-7089
    Keywords: Zinc 62 ; Zinc 65 ; Radiopharmaceutical ; 62Zn-EDDA ; Pancreas ; Positron CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The functionality of various zinc complexes of amino acid derivatives as a zinc radiopharmaceutical for pancreas PCT imaging was tested using 65Zn, which has a long half-life, and 62Zn, which has a short half-life. Because of the favorable results obtained in previous in vitro panceas section studies, the ability of those Zn complexes to retain their integrity in the presence of blood serum or in living organisms was screened using Sephadex column chromatography and mice biodistribution studies. A relationship between the structure and stability of Zn complexes played a determining role on the in vivo availability of Zn for the pancreas or liver. Among the Zn complexes tested, the tetra-coordinated structure of the Zn-EDDA complex at an equimolar ratio showed proper accumulation in the pancreas, inducing an appropriate pancreas PCT image in the dog with the positron emitter 62Zn-EDDA administered at 1 mg Zn/kg body weight.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252795
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  • 19
    Electronic Resource
    Electronic Resource
    Positive imaging of venous thrombi and thromboemboli with Ga-67 DFO-DAS-fibrinogen (1988)
    Springer
    European journal of nuclear medicine 14 (1988), S. 60-64 
    Details
    ISSN: 1619-7089
    Keywords: 67Ga-DFO-DAS-fibrinogen ; Venous thrombus ; Thrombus detection ; Pulmonary embolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A newly developed thrombus imaging agent, 67Ga-DFO-DAS-fibrinogen (67Ga-fibrinogen), was used for 22 studies in 20 cases of suspected deep venous thrombosis. Increased accumulation of 67Ga-fibrinogen in venous thrombi was depicted at 48 h after injection in 10 of the 15 cases (10 of 17 studies) who showed abnormal findings in radionuclide venography. A hot spot in the lung emboli was visualized in two cases. Seven of the eight cases having anticoagulant therapy showed increased 67Ga-fibrinogen uptake, while follow-up 67Ga-fibrinogen scintigraphy after the administration of heparin and urokinase did not reveal an abnormal hot spot in one case. 67Ga-fibrinogen can be made available simply by adding 67Ga solution to a vial containing fibrinogen-DAS-DFO conjugate. In conclusion, 67Ga-fibrinogen is considered to be a promising agent for detecting active venous thrombi and to assess the effect of anticoagulant therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253442
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  • 20
    Electronic Resource
    Electronic Resource
    Thallium-201 myocardial scintigraphy: Fractional uptake by the myocardium at rest and during exercise in patients with coronary artery disease and hypertrophic cardiomyopathy (1980)
    Springer
    European journal of nuclear medicine 5 (1980), S. 493-498 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fractional myocardial uptake of thallium-201 was estimated by routine scintigraphic evaluation at rest and during exercise in 10 control subjects, 15 patients with coronary artery disease (CAD) and 12 patients with hypertrophic cardiomyopathy (HCM). Fractional myocardial uptake of the total dose administered at rest was 3.59±0.98% in the controls, 4.43±1.17% in patients with CAD and 5.68±1.29% in patients with HCM, and uptake during exercise was 5.07±1.23% in the controls, 4.67±1.04% in the CAD group and 7.50±1.68% in the HCM group. The value in the HCM group was significantly higher than in the controls (P〈0.001 at rest) or in the CAD group (P〈0.02 at rest). A percentage increment of fractional uptake during exercise was significantly smaller in the CAD group than in the controls or the HCM group (P〈0.01). Thus, assessment of the fractional uptake appears to be a valuable adjunct to myocardial imaging when attempting a clinical assessment of CAD or HCM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252038
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