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  • 11
    Electronic Resource
    Electronic Resource
    Time-course of Tyrosine Transaminase and p -Hydroxyphenylpyruvate Oxidase Activities during Thyroid Administration (1964)
    [s.l.] : Nature Publishing Group
    Nature 201 (1964), S. 1028-1029 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Male, Wistar strain rats were obtained from Huntingdon Farms, Inc., and weighed 150-200 g at the start of each experiment. Thyroid powder (U.S.P.) was incorporated in the diet at 2 per cent by weight. For in vivo investigations, the animals were divided into 2 groups (day zero) and animals were ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2011028a0
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    Massive sarcoidosis of the liver (1968)
    Springer
    Digestive diseases and sciences 13 (1968), S. 95-106 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sarcoidosis involves the liver in approximately 65% of all patients, but laboratory evidence of liver disease is usually minimal and clinical manifestations rare. In two patients with massive liver infiltration, both followed closely with serial liver function tests and percutaneous biopsies, one died after repeated hemorrhage from esophageal varices 3 years after diagnosis, while the other, still living, has developed no evidence of portal hypertension after 4 years, although her liver changes were fully as severe. Both were treated with steroids. The mechanisms of the portal hypertension is still in doubt, although there is some evidence that it is due to presinusoidal block, without the classic pathologic changes of cirrhosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02239214
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  • 13
    Electronic Resource
    Electronic Resource
    A prospective evaluation of chemohormonal therapy remission maintenance in advanced breast cancer (1981)
    Springer
    Breast cancer research and treatment 1 (1981), S. 111-119 
    Details
    ISSN: 1573-7217
    Keywords: breast cancer ; chemohormonal therapy ; fluoxymesterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From October 1973 to October 1977 the ECOG prospectively evaluated cyclophosphamide, methotrexate, and fluorouracil (CMF) versus CMF plus fluoxymesterone (CMFH) maintenance therapies in responders to 6 months of induction therapy which consisted of either CMF, CMF plus prednisone (CMFP), or adriamycin plus vincristine (AV). Following the maintenance randomization 12% of the patients converted from a PR to a CR status. The median time from randomization to treatment failure was 9.5 months for CMFH and 6.7 months for CMF (p = 0.03). This difference was observed only for partial responders (p = 0.01) and not for complete responders. Patients receiving CMFH tended to maintain higher hemoglobin, leukocyte, and platelet levels, and receive a higher dosage of each of the cytotoxic drugs. The results are taken as evidence that the addition of fluoxymesterone to a maintenance CMF regimen provides a therapeutic advantage. It is hypothesized that this effect is due at least in part to fluoxymesterone associated maintenance of improved marrow function resulting in greater myelosuppressive drug delivery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01805863
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