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  • 11
    Electronic Resource
    Electronic Resource
    Risikomanagement in der Geburtshilfe (1998)
    Springer
    Der Gynäkologe 31 (1998), S. 380-382 
    Details
    ISSN: 1433-0393
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: ¶•zu akzeptieren, ¶•zu reduzieren, ¶•zu eliminieren, ¶•zu versichern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001290050275
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  • 12
    Electronic Resource
    Electronic Resource
    Übermäßiges Wachstum und Entwicklungsverzögerung assoziiert mit chromosomaler Deletion 22q13 (1997)
    Springer
    Monatsschrift Kinderheilkunde 145 (1997), S. 892-896 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Chromosomale Deletion 22q ; Sotos-like-Syndrom ; Key words Chromosome deletion 22q ; Overgrowth syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Of the distinct syndromes and associations featuring overgrowth, some still await further characterization. Major distinguishing marks between these overgrowth disorders include craniofacial abnormalities, statomotoric and mental retardation, and muscular hypotonia. We describe a 3-year-old girl with tall stature, facial dysmorphy, severe mental retardation, and an interstitial deletion of the long arm of chromosome 22/del(22)(q13.1;q13.33). The chromosome 22q13 deletion syndrome was only recently reported by Nesslinger et al. [1] as a new nosologic entity. Discussion: It is assumed that there is a growth gene at the chromosome 22q deletion.
    Notes: Zusammenfassung Wir berichten über ein 3jähriges Mädchen, das wegen statomotorischer und mentaler Retardierung, generalisierter Muskelhypotonie und übermäßigem Wachstum zur klinisch-genetischen Diagnostik kam. Zytogenetisch wurde eine De-novo-Deletion 22q13 festgestellt. In der Literatur wurden 7 Patienten mit einem ähnlichen Phänotyp beschrieben. Diskussion: Es ist zu vermuten, daß im Deletionsintervall 22q ein Wachstumsgen liegt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050191
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  • 13
    Electronic Resource
    Electronic Resource
    Is local intra-arterial fibrinolysis contraindicated in elderly patients with cerebral artery occlusion? (1998)
    Springer
    Neuroradiology 40 (1998), S. 822-826 
    Details
    ISSN: 1432-1920
    Keywords: Key words Cerebral artery occlusion ; Local intra-arterial fibrinolysis ; Age
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Local intra-arterial fibrinolysis (LIF) is an effective treatment for selected patients in acute thromboembolic occlusion of the middle cerebral artery, vertebrobasilar system or ophthalmic artery. However, the risk/benefit ratio of thrombolysis in patient subgroups requires classification. Advanced age has been regarded as a prognostic factor for poor clinical outcome. We report our experience with LIF in seven patients with a mean age of 79 years (range 76–83 years) who represented thromboembolic occlusion of the basilar, middle cerebral or pericallosal arteries. We discuss why advanced age need not contraindicate LIF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050692
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  • 14
    Electronic Resource
    Electronic Resource
    Zum Wirkungsmechanismus photodynamischer Furocumarine (1965)
    Springer
    Radiation and environmental biophysics 2 (1965), S. 301-302 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01191680
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  • 15
    Electronic Resource
    Electronic Resource
    Studies on the reactivation of bacteria photodamaged by psoralen (1971)
    Springer
    Radiation and environmental biophysics 7 (1971), S. 251-258 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary In photoreaction with the pyrimidine bases (thymine, cytosine, uracil) as well as with nucleic acids (DNA, RNA) a C4-cycloaddition of furocoumarins to the 5.6-double bond of pyrimidine bases takes place. The simple photoadduct furocoumarin-pyrimidine base can be split by reirradiation at wavelengths shorter than 334 nm. Reactivation of bacterial cells photodamaged by psoralen (365 nm) was tried experimentally. However, reirradiation at shorter wavelengths and with visible light of the psoralen-inactivated bacterial cells was without any effect. The inability of the shorter wavelengths to repair this photodamage was probably due to a filter effect of DNA for such wavelengths, as shown by experiments on a DNA-psoralen combination. On the other hand the observed ability of psoralen to form inter-strand cross-linkages in the photoreaction with DNA may be significant for explaining the absence of photoreactivation when the inactivated bacterial cells are irradiated with visible light.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01190236
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  • 16
    Electronic Resource
    Electronic Resource
    Frontiers in inflammatory bowel disease (1975)
    Springer
    Digestive diseases and sciences 20 (1975), S. 540-571 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01074938
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  • 17
    Electronic Resource
    Electronic Resource
    Darstellung und Eigenschaften von Dibromotrachloro-u-methylen- diantimonaten(III) and Hexabromotetrachloro-u-methylen-diantimonaten(V) (1992)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 607 (1992), S. 157-160 
    Details
    ISSN: 0044-2313
    Keywords: Dibromotetrachloro-μ methylene- diantimonates(III) ; hexabromotetrachloro-μ-metylene-diantimonates(V) ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Preparation and Properties of Dibromotetrachloro-u-methylene-diantimonates(III) and Hexabromotetrachloro-u-methylene-diantimonates(V)The complex salts (R4E)2 [Br3Cl2Sb]2 CH2 (R4E = Et4N, Ph4P, Ph4As, Ph4Sb) are obtained by the reaction of [Cl2Sb]2 with R4 EBr in dichloromethane. The oxidation of the new compounds with Br2 at -78°C, in dichloromethane, leads to the corresponding complex salts of pentavalent antimony (R4E)2[Br3Cl2Sb]2CH2.
    Notes: Die Synthese der Komplexsalze (R4E)2 [BrCl2Sb]2CH2 (R4E = Et4N, Ph4As, Ph4Sb) erfolgt durch Reaktion con [Cl2Sb]CH2 mit R4EBr in Dichlormethan. Durch Oxidation dieser Verbindungen mit Br2 bei -78°C, ebenfalls in Dichlormethan, lassen sich diese in die entsprechenden Komplexsalze des fünfwertigen Antimon (R4E)2 [Br3Cl2Sb]2 CH2 überführen.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19926070127
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  • 18
    Electronic Resource
    Electronic Resource
    μ-Oxo-bis[trimethylantion(V)] - Derivate von Dithiocarbamin-, Xanthogen-und Dithiophorsäuren (1992)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 607 (1992), S. 153-156 
    Details
    ISSN: 0044-2313
    Keywords: u-Oxy-bis[trimethylantimony(V)] dithiocarbamates, -xanthogenates -dithiophosphates ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: μ-Oxy-bis[trimethylantiomony(V)] Derivatives of Dithiocarbaminic-, Xanthogenic-, and Dithiophoric Acidsu-Oxy-bis[trimethylantimony(V)] derivatives of the type [Me3SbL]2O (L = S2CNR2, S2COR, S2P(OR)2) are obtained by the reaction of [Me3SbBr]2O with sodium dithiocarbamtes, xanthogentates and dithiophosphates. The products are characterized by elementary analysis molecular weight determination, IR, 1H-NMR, and 13C-NMR spectroscopy.
    Notes: Durch Reaktion von [Me3SbBr]2O mit Natriumsalzen diverser Dithiocarbamin-, Xanthogen-und Dithiophorsäuren erhält man u-Oxo-bis[trimethlantimon(V)]-Derivate des Typs [Me3SbL]2O (L = S2CNR2, S2COR, S2P(OR)2). Die Charakterisierung der erhaltenen Produkte erfolgt mittels Elementaranalyse, Molekulargewichtsbestimmung, sowie IR-, 1H-NMR- und 13C-NMR-Spektroskopie.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19926070126
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  • 19
    Electronic Resource
    Electronic Resource
    Methylenverbrückte Antimon(III)-dithiocarbamate, -xanthogenate und -dithiophosphate: [SbL2]2CH2 (L = S2CNR2, S2COR, S2P(OR)2)Der deutschen Forschungsgemeinschaft und dem Fonds der Chemie danken wir für die Unterstützung der Arbeit. (1992)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 607 (1992), S. 164-168 
    Details
    ISSN: 0044-2313
    Keywords: Methylene-bridged organoantimony (III) compounds ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Methylene-bridged Antimony(III)-dithiocarbamates, -xanthogenates, and -dithiophosphates: [SbL2]2CH2(L = S2CNR2, S2COR, S2P(OR)2)1 :4-reaction of [Cl2Sb]2CH2 with sodium dithiocarbamates, -xanthogenates or -dithiophoshates lead to the replacement of the chlorine atoms by the respective 1,1-dithio ligands. The products of the type [SbL2]2CH2 (L = S2CNR2, S2COR, S2P(OR)2) are studied by IR, 1H-NMR- and 13C-NMR-spectroscopy. Both spectral data and thermal stability of the compounds are compared with those of the corresponding monomethylstibanes MeSbL2.
    Notes: 1 : 4-Umsetzungen von [Cl2Sb]2CH2 mit Natriumdithiocarbamaten, -xanthogenaten oder -dithiophosphaten führen zur Substitution der Chloratome durch die jeweiligen 1,1-Dithioliganden. Die resultierenden Verbindungen vom Typ [SbL2]2CH2 (L = S2CNR2, S2COR, S2P(OR)2) sind IR, 1H-NMR- und 13C-NMr-spektroskopisch, sowie auf ihre thermische Stabilität hin untersucht. Die erhaltenen Daten werden mit denen der entsprechenden Monomethylstibane MeSbL2 verglichen.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19926070129
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  • 20
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    The Tetraspanin CD63 Is Required for Efficient IgE-Mediated Mast Cell Degranulation and Anaphylaxis [ALLERGY AND OTHER HYPERSENSITIVITIES] (2013)
    The American Association of Immunologists (AAI)
    Details
    Publication Date: 2013-09-07
    Description: Mast cell (MC) activation through the high-affinity IgE receptor FcRI leads to the release of mediators involved in immediate-type allergic reactions. Although Abs against the tetraspanins CD63 and CD81 inhibit FcRI-induced MC degranulation, the intrinsic role of these molecules in FcRI-induced MC activation is unknown. In MCs, CD63 is expressed at the cell surface and in lysosomes (particularly secretory lysosomes that contain allergic mediators). In this study, we investigated the role of CD63 in MC using a CD63 knockout mouse model. CD63-deficiency did not affect in vivo MC numbers and tissue distribution. Bone marrow–derived MC developed normally in the absence of CD63 protein. However, CD63-deficient bone marrow–derived MC showed a significant decrease in FcRI-mediated degranulation, but not PMA/ionomycin-induced degranulation, as shown by β-hexosaminidase release assays. The secretion of TNF-α, which is both released from granules and synthesized de novo upon MC activation, was also decreased. IL-6 secretion and production of the lipid mediator leukotriene C 4 were unaffected. There were no ultrastructural differences in granule content and morphology, late endosomal/lysosomal marker expression, FcRI-induced global tyrosine phosphorylation, and Akt phosphorylation. Finally, local reconstitution in genetically MC-deficient Kit w/w-v mice was unaffected by the absence of CD63. However, the sites reconstituted with CD63-deficient MC developed significantly attenuated cutaneous anaphylactic reactions. These findings demonstrate that the absence of CD63 results in a significant decrease of MC degranulation, which translates into a reduction of acute allergic reactions in vivo, thus identifying CD63 as an important component of allergic inflammation.
    Print ISSN: 0022-1767
    Electronic ISSN: 1550-6606
    Topics: Medicine
    Published by The American Association of Immunologists (AAI)
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