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  • 11
    Electronic Resource
    Electronic Resource
    Batatasins: New dormancy-inducing substances of yam bulbils (1972)
    Springer
    Planta 108 (1972), S. 369-374 
    Details
    ISSN: 1432-2048
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Three growth inhibitors, for which the names batatasins I, II and III are proposed, occur in dormant yam bulbils. Application of these inhibitors suppresses the sprouting of bulbils, and the inhibition is reversible by low-temperature stratification. Batatasins I and III were isolated as crystals and partially characterized as phenotic compounds not identical with known inhibions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389315
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  • 12
    Electronic Resource
    Electronic Resource
    Transition from Compensated to Decompensated Cardiac Hypertrophy (1999)
    Springer
    Heart failure reviews 4 (1999), S. 379-388 
    Details
    ISSN: 1573-7322
    Keywords: myocardial oxygen consumption ; calcium transient ; beta-adrenergic receptors ; sarcoplasmic reticulum ; cytokines ; endothelin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009807804152
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  • 13
    Electronic Resource
    Electronic Resource
    Marked elevation of vascular endothelial growth factor and basic fibroblast growth factor in pericardial fluid of patients with angina pectoris (1998)
    Springer
    Angiogenesis 2 (1998), S. 105-108 
    Details
    ISSN: 1573-7209
    Keywords: Angiogenesis ; collateral circulation ; coronary artery bypass graft surgery ; stable angina ; unstable angina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although we reported that basic fibroblast growth factor (bFGF) levels in pericardial fluid of patients with unstable angina are apparently increased, it was unclear whether vascular endothelial growth factor (VEGF) is also increased in patients with myocardial ischemia. Using an enzyme-linked immunosorbent assay, we measured the concentrations of VEGF and bFGF in pericardial fluid of 51 patients with open heart surgery. Patients were divided into group A (n=10) with class III unstable angina (Braunwald's classification), group B (n=24) with class I or II unstable angina or stable angina and group C (n=17) with non-ischemic heart disease. The VEGF level in pericardial fluid in group A was 83±7 pg/ml, being significantly (p〈0.001) higher than the 27±3 pg/ml in group B and the 28±5 pg/ml in group C. The concentrations of bFGF in pericardial fluid in groups A and B were 1461±579 and 1224±161 pg/ml, respectively, significantly (p〈0.05) higher than the 292±97 pg/ml in group C. The level of VEGF in pericardial fluid was increased only in patients with severe rest angina within 2 days before emergency coronary artery bypass graft surgery (CABG), while bFGF was increased in all patients undergoing CABG for coronary artery disease. Thus VEGF and bFGF may play important roles in mediating collateral growth in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009062712441
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  • 14
    Electronic Resource
    Electronic Resource
    Allelopathy of oats. II. Allelochemical effect ofl-Tryptophan and its concentration in oat root exudates (1994)
    Springer
    Journal of chemical ecology 20 (1994), S. 315-319 
    Details
    ISSN: 1573-1561
    Keywords: Allelopathy ; Avena sativa ; oat ; l-tryptophan ; root exudates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract l-Tryptophan caused growth inhibition of roots and hypocotyls (or coleoptiles) of cockscomb (Amaranthus caudatus L.), lettuce (Lactuca sativa L.), cress (Lepidium sativum L.), timothy (Phleum pratense L.), rice (Oryza sativa L.), wheat (Triticum aestivum L.), and oat (Avena sativa L.), increasing the dose ofl-tryptophan increased the inhibition. The concentrations for 50% inhibition of the root growth were 0.14, 0.15, 0.21, 0.79, 0.95, 1.7, and 2.4 mM for cockscomb, cress, lettuce, timothy, rice, wheat, and oat, respectively; the concentrations for 40% inhibition of the hypocotyl (or coleoptile) growth were 0.28, 0.33, 0.43, 2.7, 4.5, 7.2, and 15 mM for cockscomb, cress, lettuce, timothy, rice, wheat and oat, respectively. The levels ofl-tryptophan in oat seedlings and in its root exudates were 29.3 mg/kg fresh wt and 0.25 mM under light conditions, and 21.1 mg/kg fresh wt and 0.18 mM under dark conditions, respectively. The presence ofl-tryptophan in the root exudates coupled with its effect on growth suggested thatl-tryptophan may play an important role in the growth inhibition of other plants in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064440
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  • 15
    Electronic Resource
    Electronic Resource
    Allelopathy of oats. I. Assessment of allelopathic potential of extract of oat shoots and identification of an allelochemical (1994)
    Springer
    Journal of chemical ecology 20 (1994), S. 309-314 
    Details
    ISSN: 1573-1561
    Keywords: Allelochemical ; phytotoxicity ; Avena sativa ; lettuce ; Lactuca sativa ; oat ; l-tryptophan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The allelopathic potential of oat (Avena sativa L.) extracts was investigated under laboratory conditions. The ethyl ether-, acetone-, and water-soluble fractions obtained from the extract of oat shoots inhibited the germination and growth of roots and hypocotyls of lettuce (Lactuca sativa L.). The inhibitory activity of the water-soluble fraction was maximum, followed by that of ethyl ether-soluble and acetone-soluble fraction. An active principle of the water-soluble fraction was isolated and its structure was determined by spectral data asl-tryptophan.l-Tryptophan inhibited the growth of hypocotyls and roots of lettuce seedlings at concentrations greater than 0.03 and 0.1 mM, respectively. These results suggested thatl-tryptophan may be an allelochemical which affects the growth or germination of different plant species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064439
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  • 16
    Electronic Resource
    Electronic Resource
    Exudation of an allelopathic substance lepidimoide from seeds during germination (1997)
    Springer
    Plant growth regulation 22 (1997), S. 189-192 
    Details
    ISSN: 1573-5087
    Keywords: allelopathic substance ; allelopathy ; buckwheat ; Fagopyrum esculentum ; growth-promoting substance ; Helianthus annuus ; kernel ; lepidimoide ; seed coat ; seed exudate ; seed germination ; sunflower
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Lepidimoide promotes growth of the cockscomb hypocotyl. It is exuded from germinating seeds of various plant species into their culture environment. The mode of exudation of lepidimoide from seeds into the culture solution, using sunflower and buckwheat seeds, was studied in relation to seed germination. In the dry seeds, about 75% of the lepidimoide was found in the seed coat and about 25% in the kernel. Upon water imbibition it was released into the culture solution. However, the quantity of lepidimoide detected in the seed exudate was more than three times the total amount in dry and imbibed seeds, suggesting that lepidimoide was also produced de novo in the seeds and subsequently released. When seed coats or kernels were imbibed separately, the quantity of lepidimoide released from the seed coats into the culture solution was much the same as that in the dry seeds, but the amount of lepidimoide detected in the exudate of kernels was about 16 times that in the dry kernels. These results suggest that lepidimoide, already present in dry seeds, as well as that newly produced in the kernels following imbibition, was released into the environment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005885218610
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  • 17
    Electronic Resource
    Electronic Resource
    An allelopathic substance exuded from germinating watermelon seeds (1998)
    Springer
    Plant growth regulation 25 (1998), S. 1-4 
    Details
    ISSN: 1573-5087
    Keywords: allelopathic substance ; allelopathy ; Citrullus vulgaris ; plant growth regulator ; plant-selective activity ; seed exudate ; vanillic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract When watermelon seeds were cultured in a Petri dish together with amaranth, barnyard grass, cockscomb, lettuce or tomato seeds, the shoot growth of amaranth and cockscomb was markedly promoted, whereas the shoot growth of lettuce and tomato was inhibited. The shoot growth of barnyard grass was not affected. These results suggest that plant-selective allelopathic substance(s) affecting the shoot growth of other plant seedlings were exuded from watermelon seeds. An allelopathic substance was isolated from the exudates of germinating watermelon seeds and identified as vanillic acid by its spectral analysis and Rf value on TLC. Vanillic acid promoted the shoot growth of cockscomb at the concentrations of 300 to 10 mg/l and that of amaranth at the concentrations of 30 to 3 mg/l, although the shoot growth of amaranth was inhibited by 300 mg/l of vanillic acid. The shoot growth of lettuce and tomato was inhibited at the concentrations higher than 30 mg/l by vanillic acid. However, the shoot growth of barnyard grass was not affected at the concentrations used. All these results suggest that vanillic acid may play as a major component of allelopathic substance(s), which shows plant-selective activity, in the exudates of germinating watermelon seeds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005907101778
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  • 18
    Electronic Resource
    Electronic Resource
    Myocardial ischemia enhances the expression of acidic fibroblast growth factor in human pericardial fluid (2000)
    Springer
    Heart and vessels 15 (2000), S. 112-116 
    Details
    ISSN: 1615-2573
    Keywords: Key words Collateral circulation ; Growth factor ; Ischemia ; Myocyte ; Reperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acidic fibroblast growth factor (FGF) is a potent mitogen that can induce angiogenesis in vivo. We have recently reported a marked increase of basic FGF in the pericardial fluid of patients with severe coronary stenosis and an increase in vascular endothelial growth factor (VEGF) in the pericardial fluid of patients with severe myocardial ischemia. The purpose of this study was to evaluate whether acidic FGF levels in the pericardial fluid are associated with severe myocardial ischemia. Immediately after incision of the pericardium in 48 patients during open-heart surgery, 3–5 ml of pericardial fluid was obtained. Concentrations of basic FGF and VEGF in the pericardial fluid were measured using an enzyme-linked immunosorbent assay (ELISA). The ELISA system for human acidic FGF was newly developed using a rabbit antibovine acidic FGF antibody. The patients were divided into three groups (group A: 13 patients undergoing emergency coronary artery bypass grafting (CABG) for unstable angina; group B: 17 patients undergoing elective CABG for stable angina; group C: 18 patients undergoing nonischemic open-heart surgery). The VEGF level in the pericardial fluid in group A was 68 ± 59 pg/ml, which was significantly higher than 33 ± 9 pg/ml in group B and 31 ± 20 pg/ml in group C (P 〈 0.05). The concentrations of basic FGF in the pericardial fluid in groups A and B were 722 ± 601 and 773 ± 763 pg/ml, respectively, significantly higher than 263 ± 349 pg/ml in group C. The pericardial acidic FGF level in group A was 4 291 ± 2 336 pg/ml, which was also significantly higher than 2 386 ± 1 048 pg/ml in group B and 2 589 ± 990 pg/ml in group C (P 〈 0.05). The acidic FGF level correlated well with the level of VEGF (r = 0.61, P 〈 0.0001). It is concluded that the level of acidic FGF in pericardial fluid is associated with severe myocardial ischemia. This result indicates that the release of acidic FGF from the myocardial tissue into pericardial fluid is closely related to severe myocardial ischemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007264
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  • 19
    Electronic Resource
    Electronic Resource
    Age-dependent impairment of coronary collateral development in humans (2000)
    Springer
    Heart and vessels 15 (2000), S. 176-180 
    Details
    ISSN: 1615-2573
    Keywords: Key words Age ; Angina pectoris ; Angiogenesis ; Collateral development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to evaluate whether age influences collateral development in patients with coronary artery disease. The extent of collateral development to the area perfused by the infarct-related artery was graded, depending on the degree of opacification of the occluded infarct-related artery. We evaluated the extent of collateral development using coronary cineangiography in 102 patients with an acutely occluded infarct-related coronary artery within 12 h after the onset of the first acute myocardial infarction, and who had a history of long-standing effort angina. Well-developed collateral circulation was observed in 54 (53%) of the patients. The patients were divided into two groups based on their age. The prevalence of well-developed collateral circulation in the younger group (≤64 years, n = 48) was 69% (33 of 48), being significantly (P = 0.003) higher than 39% (21 of 54) in the older group (≥65 years, n = 54). We conclude that in the presence of stimuli for collateral development i.e., long-standing effort angina accompanied by severe coronary stenosis, the age of patients is a key determinant of collateral development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007269
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  • 20
    Electronic Resource
    Electronic Resource
    A nuclear complex containing PPARα/RXRα is markedly downregulated in the hypertrophied rat left ventricular myocardium with normal systolic function (2000)
    Springer
    Heart and vessels 15 (2000), S. 191-196 
    Details
    ISSN: 1615-2573
    Keywords: Key words Cardiac hypertrophy ; Fatty acid metabolism ; Peroxisome proliferator-activated receptor ; Retinoid X receptor ; Acyl-coenzyme A synthetase ; Dahl salt-sensitive rat ; Dahl salt-resistant rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The expression of genes encoding fatty acid utilization enzymes is coordinately downregulated during the development of cardiac hypertrophy and failure. However, molecular mechanisms that mediate this downregulation are unknown. Peroxisome proliferator-activated receptor (PPAR) response elements (PPREs) have been identified in promoters of many genes involved in fatty acid utilization, where they function as positive regulatory elements. PPARs bind to PPREs as heterodimers with retinoid X receptors (RXRs). Primary cardiac myocytes from neonatal rats were transfected with a reporter construct driven by the C promoter of rat acyl-coenzyme A synthetase (ACS) gene. Stimulation with phenylephrine, a potent inducer of hypertrophy, markedly downregulated the activity of this promoter. By use of electrophoretic mobility-shift assays (EMSAs) using PPRE in the rat ACS promoter as a probe, we found a sequence-specific protein–DNA complex in the nuclear extract from adult rat left ventricular (LV) myocardium. Supershift experiments revealed that this complex was immunoreactive for PPARα and RXRα. We compared the activity of this complex in LV nuclear extracts from Dahl salt-sensitive rats (DSs) with hypertension and control age-matched Dahl salt-resistant rats (DRs). Even at the stage of concentric LV hypertrophy with normal systolic function, the activity of the band was markedly diminished in DSs compared with DRs. However, immunoblot analyses showed no difference in LV expression levels of PPARα or RXRα between DSs and DRs. These findings indicate that a nuclear complex of PPARα/RXRα is present in adult rat LV and is markedly downregulated in the hypertrophied LV from DS rats, which may account for the loss of transcriptional activation. The downregulation of this complex precedes LV systolic dysfunction and is mediated at the posttranslational levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003800070022
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