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  • 11
    Electronic Resource
    Electronic Resource
    Starch-gel electrophoresis of rat-serum proteins
    Amsterdam : Elsevier
    BBA - Biochimica et Biophysica Acta 48 (1961), S. 445-451 
    Details
    ISSN: 0006-3002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0006-3002(61)90042-7
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  • 12
    Electronic Resource
    Electronic Resource
    Crystal and molecular structure of 2′,4′-dimethoxyflavone (1993)
    Springer
    Journal of chemical crystallography 23 (1993), S. 297-300 
    Details
    ISSN: 1572-8854
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract C17H14O4,M r =282.3, triclinic,P-1,a=8.469(3),b=8.516(2),c=20.425(8)Å,α=84.95(3),β=81.98(3), γ=70.47(2)°,V=1373(13)Å3,Z=4,D x =1.365 g cm−3, λ(MoK α)=0.71069 Å,μ=0.91 cm−1,F(000)=592,T=294K,R=0.038 for 3577 observed reflections (F〉3σ (F)). The asymmetric unit is composed of two molecules. These two molecules, which are in planar conformations, differ in 4′-methoxyl group orientation. Short intramolecular contacts are found between the γ-benzopyran portion and the dimethoxyphenyl ring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01263590
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  • 13
    Electronic Resource
    Electronic Resource
    p 53 gene rearrangements in chronic myelocytic leukemia (1993)
    Springer
    Annals of hematology 66 (1993), S. 81-83 
    Details
    ISSN: 1432-0584
    Keywords: p 53 Gene ; CML ; Rearrangements ; Deletions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We performed Southern-blot analysis of the p 53 gene in 41 consecutive patients with typical chronic myelocytic leukemia (CML). In two of them, we were able to study cells during both the chronic and the accelerated phases. Only one of the 29 chronic-phase samples had rearrangement of the p 53 gene, whereas three of the nine accelerated-phase samples and one of the five patients in blast crisis exhibited rearrangements. Gene deletion was observed in two patients, one in accelerated phase and the other in blast crisis. One patient with a nonrearranged p 53 gene in chronic phase showed rearrangement after progression to the accelerated phase. On the other hand, one patient in accelerated phase exhibited rearrangements which disappeared after reversion to chronic phase with successful treatment. Our findings support the opinion that alterations of the p 53 gene may play an important role in CML evolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695889
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  • 14
    Electronic Resource
    Electronic Resource
    Treatment of advanced gastric cancer with the combination fluorouracil, leucovorin, etoposide, and cisplatin: a phase II study of the ONCOPAZ cooperative group (1995)
    Springer
    Cancer chemotherapy and pharmacology 36 (1995), S. 255-258 
    Details
    ISSN: 1432-0843
    Keywords: Key words Gastric cancer ; Chemotherapy ; Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A phase II study was performed to assess the efficacy and toxicity of the combination of 5-fluorouracil (5-FU), leucovorin (LV), etoposide, and cisplatin (FLEP) in patients with advanced gastric carcinoma. A total of 46 consecutive, previously untreated patients with unresectable, measurable gastric carcinoma were treated with 300 mg/m2 LV, 100 mg/m2 etoposide, 500 mg/m2 5-FU, and 30 mg/m2 cisplatin on days 1–3 every 28 days. All courses were given on an outpatient basis. A total of 169 courses of treatment were given. In all, 18 of the 46 patients (39%) had an objective response [95% confidence interval (CI), 25%–54%] and 2 (4%) patients experienced a clinical complete response. The median duration of response was 5 months. The main side effects were hematological and gastrointestinal. Grade 3–4 toxicity was encountered as follows: leukopenia, in 9.5% of the courses; anemia, in 3%; thrombocytopenia, in 3%; nausea/ vomiting, in 4%; and diarrhea, in 5%. Hospitalization due to fever and granulocytopenia was required in 5 patients, 3 of whom died of sepsis. In conclusion, FLEP shows moderate activity in patients with advanced gastric carcinoma, albeit at the cost of a high degree of toxicity. For this reason we do not recommend its use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050318
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  • 15
    Electronic Resource
    Electronic Resource
    Treatment of advanced gastric cancer with the combination fluorouracil, leucovorin, etoposide, and cisplatin: a phase II study of the ONCOPAZ cooperative group (1995)
    Springer
    Cancer chemotherapy and pharmacology 36 (1995), S. 255-258 
    Details
    ISSN: 1432-0843
    Keywords: Gastric cancer ; Chemotherapy ; Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A phase II study was performed to assess the efficacy and toxicity of the combination of 5-fluorouracil (5-FU), leucovorin (LV), etoposide, and cisplatin (FLEP) in patients with advanced gastric carcinoma. A total of 46 consecutive, previously untreated patients with unresectable, measurable gastric carcinoma were treated with 300 mg/m2 LV, 100 mg/m2 etoposide, 500 mg/m2 5-FU, and 30 mg/m2 cisplatin on days 1–3 every 28 days. All courses were given on an outpatient basis. A total of 169 courses of treatment were given. In all, 18 of the 46 patients (39%) had an objective response [95% confidence interval (CI), 25%–54%] and 2 (4%) patients experienced a clinical complete response. The median duration of response was 5 months. The main side effects were hematological and gastrointestinal. Grade 3–4 toxicity was encountered as follows: leukopenia, in 9.5% of the courses; anemia, in 3%; thrombocytopenia, in 3%; nausea/vomiting, in 4%; and diarrhea, in 5%. Hospitalization due to fever and granulocytopenia was required in 5 patients, 3 of whom died of sepsis. In conclusion, FLEP shows moderate activity in patients with advanced gastric carcinoma, albeit at the cost of a high degree of toxicity. For this reason we do not recommend its use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685856
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  • 16
    Electronic Resource
    Electronic Resource
    Further evidence for the molecular heterogeneity of chronic myeloid leukemia (1991)
    Springer
    Annals of hematology 62 (1991), S. 217-220 
    Details
    ISSN: 1432-0584
    Keywords: Chronic myeloid leukemia ; Molecular analysis ; Cytogenetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cytogenetic and molecular techniques were performed on samples obtained from 29 patients with chronic myelocytic leukemia (CML); 27 were in the chronic phase and two were in blast crisis. A further five cases were also analyzed, two with atypical CML (aCML), one with chronic neutrophilic leukemia (CNL), and two with juvenile CML (JCML). Most of the cases with typical CML were Philadelphia chromosome (Ph) positive and had a rearrangement within the major breakpoint cluster region (M-bcr). One of these cases was shown to be Ph positive but showed no rearrangement within the M-bcr. Two cases with clinical features typical of CML were Ph negative. One of these showed a rearrangement within the M-bcr, but no rearrangement was demonstrated in the other. Both patients in blast crisis were Ph positive and M-bcr positive. One showed a second Ph. Patients with aCML were Ph negative and had no M-bcr rearrangement. A polymorphism within the M-bcr was found withBglII in one case. No Ph chromosome or M-bcr rearrangement was found in CNL or JCML. These data support the molecular heterogeneity reported in CML.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01729835
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  • 17
    Electronic Resource
    Electronic Resource
    All-trans retinoic acid in acute promyelocytic leukemia: Preliminary results in Cuba (1992)
    Springer
    Annals of hematology 65 (1992), S. 121-123 
    Details
    ISSN: 1432-0584
    Keywords: Retinoic acid ; Acute promyelocytic leukemia ; Disseminated intravascular coagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven patients with acute promyelocytic leukemia (APL) were treated with all-trans retinoic acid (ATRA). Five (71.4%) achieved complete remission (CR). Most side effects were transient and well tolerated. Hyperleukocytosis was the major adverse effect. These observations confirm the efficacy of ATRA for inducing CR in APL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695810
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  • 18
    Electronic Resource
    Electronic Resource
    Treatment of metastatic malignant melanoma with cisplatin plus tamoxifen (1996)
    Springer
    Cancer chemotherapy and pharmacology 38 (1996), S. 191-194 
    Details
    ISSN: 1432-0843
    Keywords: Key words Malignant melanoma ; Chemotherapy ; Cisplatin ; Tamoxifen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A phase II study was performed to assess the efficacy and toxicity of the combination of cisplatin (CDDP) and tamoxifen (TAM) in patients with metastatic malignant melanoma (MM). A total of 31 consecutive previously untreated patients with unresectable measurable MM were given 100 mg/m2 CDDP every 21 days and 60 mg TAM every 12 h daily. All courses were given on an outpatient basis. A total of 119 courses of treatment were given. In all, 5 of the 31 patients (16%) had an objective response (95% confidence interval 5.3 – 34%) and 2 (6%) achieved a clinical complete response. The median duration of response was 7 months. The main side effect was gastrointestinal: 13% of the patients experienced grade 3/4 nausea/vomiting. Hematological or neurological toxicities were mild and rare. In conclusion, the combination CDDP-TAM has limited activity in MM, although its toxicity is tolerable. Our results do not allow us to recommend its use for the treatment of MM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050469
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  • 19
    Electronic Resource
    Electronic Resource
    Doctors also suffer when giving bad news to cancer patients (1996)
    Springer
    Supportive care in cancer 4 (1996), S. 61-63 
    Details
    ISSN: 1433-7339
    Keywords: Truth disclosure ; Cancer communication ; Psychological stress in doctors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Giving bad news to patients with cancer may generate stress in doctors, who use distancing tactics. The causes of this anxiety come from social conventions and its consequences affect both doctors and their patients. There is no “gold standard” by which stress may be overcome during the interview but we offer some suggestions that may help.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01769878
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  • 20
    Electronic Resource
    Electronic Resource
    Bone metastases as the first manifestation of a tumour (1991)
    Springer
    International orthopaedics 15 (1991), S. 373-376 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Revue de 29 dossiers de malades chez qui le premier signe de néoplasie était une métastase osseuse. Deux des cancers primitifs ont pu être identifiés: l'un du poumon et l'autre de l'utérus, et dans deux cas on a posé le diagnostic présumé de tumeur du sein et de la prostate. Quand on découvre une métastase osseuse et que le cancer primitif n'est pas connu le bilan doit comporter une anamnèse, un examen clinique, les tests habituels de laboratoire et des radiographies pulmonaires. Une mammographie peut être demandée chez la femme, surtout s'il existe une adénopathie axillaire palpable. On ne pratiquera un examen tomodensitométrique de l'abdomen et une bronchoscopie que si des arguments cliniques les justifient.
    Notes: Summary We have reviewed 29 patients whose first sign of a tumour was a bone metastasis. Two primaries were identified, lung adenocarcinoma and uterine adenocarcinoma and in 2 cases a presumptive diagnosis of tumours of the breast and prostate was made. The mean survival time was 3 months. When bone metastases are found in the absence of a primary tumour, investigation must include a clinical history, physical examination, routine laboratory tests and chest radiographs. Mammography should be done in women, particularly when there are palpable axillary nodes. Abdominal CT scanning and bronchoscopy should only be undertaken when there is a clinical indication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186882
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