GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Material
Publisher
Person/Organisation
Language
Years
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    A spontaneous depressive pattern in adult female rhesus macaques
    Springer Science and Business Media LLC ; 2015
    In:  Scientific Reports Vol. 5, No. 1 ( 2015-06-10)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2015-06-10)
    Abstract: Non-human primates offer unique opportunities to study the development of depression rooted in behavioral and physiological abnormalities. This study observed adult female rhesus macaques within social hierarchies and aimed to characterize the physiological and brain abnormalities accompanying depressive-like behavior. The behaviors of 31 female rhesus macaques from 14 different breeding groups were video recorded and the footage was analyzed using the focal animal technique. There were 13 monkeys who never displayed huddling behavior (non-huddlers). The remaining 18 monkeys were divided into two groups according the mean time spent in the huddle posture. Four monkeys were designated as high huddlers, whereas the other 14 monkeys were low huddlers. An inverse relationship was discovered between social rank and depression. High huddlers spent more time engaging in physical contact and in close proximity to other monkeys, as well as less time spontaneously and reactively locomoting, than low huddlers and/or non-huddlers. Cortisol levels measured from the hair were elevated significantly in high huddlers compared with low huddlers and non-huddlers and the measured cortisol levels were specifically higher in high huddlers than subordinate or dominant control monkeys. Regional cerebral blood flow data revealed significant and widespread decreases in high huddlers compared with non-huddlers.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/srep11267
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2615211-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Mitigation of Reverse Short-Channel Effect With Multilayer TiN/Ti/TiN Metal Gates in Gate Last PMOSFETs
    Institute of Electrical and Electronics Engineers (IEEE) ; 2014
    In:  IEEE Electron Device Letters Vol. 35, No. 8 ( 2014-8), p. 811-813
    Details
    In: IEEE Electron Device Letters, Institute of Electrical and Electronics Engineers (IEEE), Vol. 35, No. 8 ( 2014-8), p. 811-813
    Type of Medium: Online Resource
    ISSN: 0741-3106 , 1558-0563
    URL: Article
    DOI: 10.1109/LED.2014.2331356
    RVK:
    ZG 1100
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2014
    detail.hit.zdb_id: 245158-X
    detail.hit.zdb_id: 2034325-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis
    XMLink ; 2020
    In:  Allergy, Asthma & Immunology Research Vol. 12, No. 2 ( 2020), p. 176-
    Details
    In: Allergy, Asthma & Immunology Research, XMLink, Vol. 12, No. 2 ( 2020), p. 176-
    Type of Medium: Online Resource
    ISSN: 2092-7355 , 2092-7363
    URL: Article
    DOI: 10.4168/aair.2020.12.2.176
    Language: English
    Publisher: XMLink
    Publication Date: 2020
    detail.hit.zdb_id: 2545725-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Solidified glomerulosclerosis, identified using single glomerular proteomics, predicts end-stage renal disease in Chinese patients with type 2 diabetes
    Springer Science and Business Media LLC ; 2021
    In:  Scientific Reports Vol. 11, No. 1 ( 2021-02-25)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-02-25)
    Abstract: Few histological prognostic indicators for end-stage renal disease (ESRD) have been validated in diabetic patients. This biopsy-based study aimed to identify nephropathological risk factors for ESRD in Chinese patients with type 2 diabetes. Histological features of 322 Chinese type 2 diabetic patients with biopsy-confirmed diabetic nephropathy (DN) were retrospectively analysed. Cox proportional hazards analysis was used to estimate the hazard ratio (HR) for ESRD. Single glomerular proteomics and immunohistochemistry were used to identify differentially expressed proteins and enriched pathways in glomeruli. During the median follow-up period of 24 months, 144 (45%) patients progressed to ESRD. In multivariable models, the Renal Pathology Society classification failed to predict ESRD, although the solidified glomerulosclerosis (score 1: HR 1.65, 95% confidence interval [CI] 1.04–2.60; score 2: HR 2.48, 95% CI 1.40–4.37) and extracapillary hypercellularity (HR 2.68, 95% C I 1.55–4.62) were identified as independent risk factors. Additionally, single glomerular proteomics, combined with immunohistochemistry, revealed that complement C9 and apolipoprotein E were highly expressed in solidified glomerulosclerosis. Therefore, solidified glomerulosclerosis and extracapillary hypercellularity predict diabetic ESRD in Chinese patients. Single glomerular proteomics identified solidified glomerulosclerosis as a unique pathological change that may be associated with complement overactivation and abnormal lipid metabolism.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-021-83856-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2615211-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Predictive Factors Upon Discontinuation of Renal Replacement Therapy for Long‐Term Chronic Dialysis and Death in Acute Kidney Injury Patients
    Wiley ; 2017
    In:  Artificial Organs Vol. 41, No. 12 ( 2017-12), p. 1127-1134
    Details
    In: Artificial Organs, Wiley, Vol. 41, No. 12 ( 2017-12), p. 1127-1134
    Abstract: The specific timing for discontinuing renal replacement therapy (RRT) in acute kidney injury (AKI) patients is debatable. The predictive abilities of variables at the time of discontinuation of RRT for the long‐term prognoses of patients have not been explored. This study aimed to explore the prognostic factors upon discontinuation of RRT for long‐term chronic dialysis and death of patients with acute RRT‐requiring AKI, thus improving decision making regarding the discontinuation of RRT and the follow‐up of patients thereafter. A cohort of 302 AKI patients who required acute RRT and remained alive and free of dialysis for at least 30 days after discharge from January 2009 to December 2012 were followed up. The predictive abilities of general characteristics, RRT details, and variables upon discontinuation of RRT for long‐term chronic dialysis and all‐cause death were evaluated using Cox proportional hazards models. Kaplan–Meier analysis with a log‐rank test was used to compare the survival curves between the strata of levels of good predictors upon discontinuation of RRT. After a median follow‐up time of 4.1 years, 20 (6.6%) patients initiated chronic dialysis and 56 (18.5%) patients died. A higher CysC level upon discontinuation of RRT (HR 1.520, 95% CI 1.082–2.135; P  = 0.016), comorbid chronic kidney disease, and a higher non‐renal Charlson comorbidity index (CCI) were independently predictive for chronic dialysis. The hemoglobin level upon discontinuation of RRT was inversely predictive of death (HR 0.986, 95% CI 0.973–0.999; P  = 0.035), and comorbid malignancy, the presence of multiple organ dysfunction syndrome, and a higher non‐renal CCI also predicted death. Urine output upon discontinuation of RRT was marginally inversely predictive of death (HR 0.997, 95% CI 0.994–1.000; P  = 0.056). Patients who discontinued RRT with CysC levels 〈 2.97 mg/L, hemoglobin levels 〉 85 g/L, and urine output 〉 1130 mL/24 h showed significantly higher non‐chronic dialysis and survival rates according to a log‐rank test. Our study suggested that upon discontinuation of RRT, higher serum CysC levels had the most promising predictive value for long‐term chronic dialysis, and lower hemoglobin levels predicted long‐term death; lower urine output also marginally predicted long‐term death. Based on the remission of the comprehensive condition, lower CysC levels and higher hemoglobin levels and urine output should be considered in the decision to stop RRT. Patients showing worse levels of these indices upon discontinuation of RRT should undergo stricter follow‐up and treatment to improve long‐term outcomes.
    Type of Medium: Online Resource
    ISSN: 0160-564X , 1525-1594
    URL: Issue
    URL: Article
    DOI: 10.1111/aor.2017.41.issue-12
    DOI: 10.1111/aor.12927
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2003825-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    P0592RISK FACTORS FOR SEPSIS ASSCOCIATED-ACUTE KIDNEY INJURY IN INTENSIVE CARE UNIT PATIENTS
    Oxford University Press (OUP) ; 2020
    In:  Nephrology Dialysis Transplantation Vol. 35, No. Supplement_3 ( 2020-06-01)
    Details
    In: Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 35, No. Supplement_3 ( 2020-06-01)
    Abstract: To explore the risk factors of acute kidney injury in patients with sepsis in intensive care unit (ICU). Method The medical records of patients diagnosed with sepsis in ICU of west China hospital of Sichuan university from March 2009 to June 2016 were retrospectively analyzed. Differences between AKI group and Non-AKI group in general data, background disease, ICU entry and exit dates, complications, laboratory data and other related data were analyzed through univariate and multivariate statistical methods. Results A total of 2331 patients with sepsis were included in the study, including 626 patients in the AKI group and 1695 patients in the Non-AKI group. The multivariate logistic regression analysis confirmed that age & gt;40 yr. [odds ratio (OR) =2.811], diabetes (OR=2.818), hypertension/coronary heart disease (OR=1.781), CKD (OR=13.221), the length of ICU stay ≥14 days (OR=3.327), heart failure (OR=2.316), ARDS (OR=2.105), SAP (OR=2.566), hypotension (OR=2.048), hypoproteinemia (OR=1.607), lactic acidosis (OR=2.380), hypoproteinemia (OR=1.607), organ failure & gt;1 (OR=4.604),WBC & gt; 10 ×109/L (OR=4.197), serum creatinine (OR=4.535), PCT (OR=1.808), Cys-C (OR=7.066), mild anemia (OR=2.321), moderate anemia (OR=4.047), and severe anemia (OR=6.100) were all independent risk factors of SA-AKI. Conclusion A variety of risk factors are related to the occurrence of SA-AKI. Early identification and monitoring of risk factors for SA-AKI and early prevention of AKI can improve the prognosis of sepsis patients.
    Type of Medium: Online Resource
    ISSN: 0931-0509 , 1460-2385
    URL: Article
    DOI: 10.1093/ndt/gfaa142.P0592
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1465709-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Redox‐Mediated Single‐Molecule Transistor with A Subthreshold Swing Down To 120 mV Decade −1
    Wiley ; 2023
    In:  Advanced Functional Materials
    Details
    In: Advanced Functional Materials, Wiley
    Abstract: The single‐molecule electronic devices offer the ultimate solution to miniaturize integrated circuits, and subthreshold swing (SS) is the key indicator of the power consumption for single‐molecule transistors but is still quite restricted. In this study, the redox‐mediated single‐molecule transistor with a SS down to 120 mV decade −1 in the faradaic potential region via the electrochemical‐STM break junction (EC‐STM‐BJ) technique is fabricated. With an off‐state leakage current of less than 10 p A and an on/off ratio of 100, the balance between low static power consumption and a high switching ratio is achieved. The theoretical investigations reveal that the conductance tuning is from the difference of transmission in the redox process. The study provides a new strategy for the design of single‐molecule transistors with promising SS, which is essential for the potential application of single‐molecule devices.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Article
    DOI: 10.1002/adfm.202302985
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Effect of in Situ Formed Emulsions on Enhanced Extra-Heavy Oil Recovery by Surfactant Flooding
    IOP Publishing ; 2021
    In:  IOP Conference Series: Earth and Environmental Science Vol. 702, No. 1 ( 2021-03-01), p. 012046-
    Details
    In: IOP Conference Series: Earth and Environmental Science, IOP Publishing, Vol. 702, No. 1 ( 2021-03-01), p. 012046-
    Abstract: Thermochemical flooding is becoming more popular nowadays as a subsequent EOR method after thermal recovery in extra-heavy oil reservoirs. During this process, in-situ emulsions could happen due to interfacial active components existing in heavy crude oil. The enhanced oil recovery is inevitably related with the formation of emulsions, which is one of the main mechanisms and deserves a thorough study. Also, the features of relative permeability curves during thermochemical flooding should be investigated further, because they are very important but usually are difficult to obtain since physical reactions could happen. Based on core-flooding experiments, combined with careful observation of produced crude oil emulsion morphology, this paper compared and analyzed the features of relative permeability curves and displacement efficiency at different conditions, and the mechanisms of extra-heavy oil production by surfactant displacement is then investigated. The surfactant used are provided by the oilfield at a varied mass fraction of 0.1%, 0.2% and 0.3% and under temperature of 100, 150 and 180 °C. The relative permeability data were processed with JBN method. The experimental results show that both the oil and water relative permeability increase as the temperature increases. As surfactant concentration increases, the relative permeability of the aqueous phase decreases as opposite to oil. The ultimate recovery increased with the increase of temperature and surfactant concentration. Except for the oil viscosity reduction by surfactant, it is interesting to note that the formation of crude oil emulsions (mainly O/W emulsions) are observed to be positively impacting the oil recovery factor. As surfactant concentration increases, larger size of dispersed phase in the emulsions were observed in the effluent corresponding to a higher oil recovery factor. This work is of great significance for heavy oil research and field development.
    Type of Medium: Online Resource
    ISSN: 1755-1307 , 1755-1315
    URL: Article
    DOI: 10.1088/1755-1315/702/1/012046
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2021
    detail.hit.zdb_id: 2434538-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Data_Sheet_1.ZIP
    Frontiers Media SA ; 2021
    In:  Frontiers in Medicine Vol. 8 ( 2021-4-13)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 8 ( 2021-4-13)
    Abstract: The aim of the present study was to investigate the effect of erythropoietin (EPO) on contrast-induced nephrology (CIN) in vivo and in vitro . Male C57BL/6J mice were divided into four groups: control, CIN (iohexol 6.0 g/kg), EPO (3,000 IU/kg), and CIN+EPO. Hematoxylin and eosin (H & amp;E) staining and biochemical index analyses were performed to evaluate renal injury. The cellular proliferation rate was detected using the Cell Counting Kit-8 (CCK-8) assay. In addition, a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay and flow cytometric assay were used to assess the apoptosis of tissue and cells, respectively. Renal protein expression associated with apoptosis, pyroptosis, and signaling pathways was determined by Western blot (WB) assays for tissues and cells. The results showed that EPO significantly decreased serum creatinine, blood urea nitrogen, and cystatin C levels and alleviated renal histological changes in vivo . The protein levels of Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway components were overexpressed in the EPO treatment group. Furthermore, EPO suppressed the cell apoptosis and pyroptosis; decreased the protein levels of cleaved caspase-3, Bax, gasdermin D (GSDMD), and caspase-1; and enhanced the expression of Bcl-2. In summary, EPO could exert renoprotective effect by activating the JAK2/STAT3 signaling pathway, which may be a novel potential therapy for the treatment of CIN in the clinic.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    URL: Article
    DOI: 10.3389/fmed.2021.634882
    DOI: 10.3389/fmed.2021.634882.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2775999-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Procalcitonin, Interleukin-6 and C-reactive Protein Levels Predict Renal Adverse Outcomes and Mortality in Patients with Acute Type A Aortic Dissection
    Frontiers Media SA ; 2022
    In:  Frontiers in Surgery Vol. 9 ( 2022-4-28)
    Details
    In: Frontiers in Surgery, Frontiers Media SA, Vol. 9 ( 2022-4-28)
    Abstract: Acute type A aortic coarctation (AAAD) is a highly deadly and serious life-threatening disease. The purpose of this study was to estimate the predictive value of peak procalcitonin, interleukin-6, and C-reactive protein levels on adverse renal outcomes and mortality in patients undergoing surgery for AAAD. Methods Perioperative peak PCT, CRP, and IL-6 levels were retrospectively collected in 331 patients hospitalized with AAAD from 2009 to 2021. The primary endpoints were AKI stage 2–3 and mortality. The receiver operating characteristic (ROC) curves were used to compare the predictive values of peak PCT, CRP, and IL-6 for different clinical outcomes. Multivariable logistic regression analysis was used to find risk factors for AKI and 30-day mortality. Results The incidence of AKI stage 2–3 following AAAD was 50.8% (168/331). The 30-day and overall mortality were significantly greater in the AKI 2–3 group than in the AKI 0–1 group ( P  = 0.000). ROC curve analysis showed that peak PCT, with an area under the ROC curve (AUC) of 0.712, was a more accurate predictor of adverse renal outcomes than peak IL-6 and CRP. Multivariable logistic regression analysis revealed that PCT  & gt; 0.39 ng/mL was an independent risk factor for AKI stage 2–3. Peak IL-6  & gt; 259 pg/mL was found to be an independent risk factor for 30-day mortality. Conclusion In patients with surgery for AAAD, peak PCT provides a well-predictive indicator of AKI stage 2–3 and peak IL-6 indicates a favorable predictor of 30-day mortality.
    Type of Medium: Online Resource
    ISSN: 2296-875X
    URL: Article
    DOI: 10.3389/fsurg.2022.902108
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2773823-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...