In:
Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-7-11), p. 1-19
Kurzfassung:
Abnormal function of suborganelles such as mitochondria and endoplasmic reticulum often leads to abnormal function of cardiomyocytes or vascular endothelial cells and cardiovascular disease (CVD). Mitochondria-associated membrane (MAM) is involved in several important cellular functions. Increasing evidence shows that MAM is involved in the pathogenesis of CVD. MAM mediates multiple cellular processes, including calcium homeostasis regulation, lipid metabolism, unfolded protein response, ROS, mitochondrial dynamics, autophagy, apoptosis, and inflammation, which are key risk factors for CVD. In this review, we discuss the structure of MAM and MAM-associated proteins, their role in CVD progression, and the potential use of MAM as the therapeutic targets for CVD treatment.
Materialart:
Online-Ressource
ISSN:
1942-0994
,
1942-0900
DOI:
10.1155/2021/4578809
Sprache:
Englisch
Verlag:
Hindawi Limited
Publikationsdatum:
2021
ZDB Id:
2455981-7
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