In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 11 ( 2022-11-21), p. e0273745-
Abstract:
Sickle cell anemia (SCA) is caused by a single point variation in the β-globin gene ( HBB ): c.20A 〉 T (p.Glu7Val), in homozygous state. SCA is characterized by sickling of red blood cells in small blood vessels which leads to a range of multiorgan complications, including kidney dysfunction. This case-control study aims at identifying sickle cell nephropathy biomarkers in a group of patients living with SCA from Senegal. A total of 163 patients living with SCA and 177 ethnic matched controls were investigated. Biological phenotyping included evaluation of glycemia, glucosuria, albuminuria, proteinuria, tubular proteinuria, serum creatinine, urine creatinine, urine specific gravity and glomerular filtration rate. Descriptive statistics of biomarkers were performed using the χ2 –test, with the significance level set at p 〈 0.05. Patients living with SCA had a median age of 20 years (range 4 to 57) with a female sex frequency of 53.21%. The median age of the control participants was 29 years (range: 4–77) with a female sex frequency of 66.09%. The following proportions of abnormal biological indices were observed in SCA patients versus (vs.) controls, as follows: hyposthenuria: 35.3%vs.5.2% (p 〈 0.001); glomerular hyperfiltration: 47.66%vs.19.75% (p 〈 0.001), renal insufficiency: 5.47%vs.3.82% (p = 0.182); microalbuminuria: 42.38%vs.5.78% (p 〈 0.001); proteinuria: 39.33%vs.4.62% (p 〈 0.001); tubular proteinuria: 40.97%vs.4.73% (p 〈 0.001) and microglucosuria: 22.5%vs.5.1% (p 〈 0.001). This study shows a relatively high proportion of SCA nephropathy among patients living with SCA in Senegal. Microglucosuria, proteinuria, tubular proteinuria, microalbuminuria, hyposthenuria and glomerular hyperfiltration are the most prevalent biomarkers of nephropathy in this group of Senegalese patients with SCA.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0273745
DOI:
10.1371/journal.pone.0273745.t001
DOI:
10.1371/journal.pone.0273745.t002
DOI:
10.1371/journal.pone.0273745.t003
DOI:
10.1371/journal.pone.0273745.t004
DOI:
10.1371/journal.pone.0273745.t005
DOI:
10.1371/journal.pone.0273745.s001
DOI:
10.1371/journal.pone.0273745.s002
DOI:
10.1371/journal.pone.0273745.s003
DOI:
10.1371/journal.pone.0273745.s004
DOI:
10.1371/journal.pone.0273745.s005
DOI:
10.1371/journal.pone.0273745.s006
DOI:
10.1371/journal.pone.0273745.s007
DOI:
10.1371/journal.pone.0273745.s008
DOI:
10.1371/journal.pone.0273745.s009
DOI:
10.1371/journal.pone.0273745.s010
DOI:
10.1371/journal.pone.0273745.r001
DOI:
10.1371/journal.pone.0273745.r002
DOI:
10.1371/journal.pone.0273745.r003
DOI:
10.1371/journal.pone.0273745.r004
DOI:
10.1371/journal.pone.0273745.r005
DOI:
10.1371/journal.pone.0273745.r006
DOI:
10.1371/journal.pone.0273745.r007
DOI:
10.1371/journal.pone.0273745.r008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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