In:
The Journal of Immunology, The American Association of Immunologists, Vol. 122, No. 6 ( 1979-06-01), p. 2630-2632
Abstract:
Serologic, structural and immunogenic data accumulated in animal model systems suggest that some tumor-specific antigens are newly expressed or modified histocompatibility antigens (see for review 1). This evidence raises the possibility that in man some tumor-associated antigens may derive from histocompatibility (HLA) antigens. We tested this hypothesis in the human melanoma system by investigating whether human chromosome 6, which carries the major histocompatibility complex region (2, 3), controls the expression of serologically detectable melanoma-associated antigens (sd-MAA). An absence of genetic linkage between sd-MAA and HLA antigens would cast serious doubts on the proposition that sd-MAA are modified HLA antigens. In our studies, we prepared hybrid clones by fusing cultured human melanoma cells with murine fibroblasts. We tested these hybrids for expression of sd-MAA and HLA-A and B antigens after a number of passages in vitro, during which a preferential loss of human chromosomes resulted in cells with a few human chromosomes superimposed on essentially complete murine genomes.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.122.6.2630
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
1979
detail.hit.zdb_id:
1475085-5
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