In:
Combinatorial Chemistry & High Throughput Screening, Bentham Science Publishers Ltd., Vol. 25, No. 12 ( 2022-10), p. 2112-2125
Abstract:
HuanglianShangqing pill (HLSQ), a well-known traditional
Chinese medicine (TCM), has been used to treat fever in China for a long time. Our previous study had demonstrated that a total of 45 prototype components of HLSQ could be absorbed into the
plasma of rats after intragastric administration. However, the detailed mechanisms related to the antipyretic effects of HLSQ were still unclear. Materials and Methods: In the present work, urinary metabolomics coupled with network pharmacology
were employed to evaluate the mechanisms of HLSQ in the treatment of fever compared with ibuprofen (IBU) and paracetamol (APAP). Results: In pyrexia rats, a total of 11 potential metabolites and a disturbed TCA cycle were found.
The metabolic regulation effects of HLSQ on fever rats were similar to APAP and could make the TCA cycle disorder return to normal by reducing citrate, β-hydroxybutyrate, succinate. In addition,
HLSQ could adjust the intestinal microbial disorder and inhibit inflammatory factors, including IL6, TNF, VEGFA, TP53, STAT3, etc. There were 40 components acting on fever targets in
HLSQ; among them, luteolin, apigenin, ursolic acid, kaempferol, wogonin, daidzein, baicalein, emodin, berberine, and oroxylin A were the main active compounds of HLSQ in the treatment of
fever. Conclusion: The antipyretic mechanisms of HLSQ are inhibition of inflammatory factors, action
on the TCA cycle, and regulation of gut microbiota.
Type of Medium:
Online Resource
ISSN:
1386-2073
DOI:
10.2174/1386207325666220215144847
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2022
SSG:
15,3
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