In:
Clinical Science, Portland Press Ltd., Vol. 86, No. 6 ( 1994-06-01), p. 703-707
Abstract:
1. Urinary excretion of endothelin-1-like immunoreactivity and urinary excretion of other parameters (β2-microglobulin, N-acetyl-β-d-glucosaminidase and microalbumin) were measured before, within 1 week after and 2 weeks after the administration of cis-platinum in five young male patients with testicular cancer (mean age 33.0 years) and were compared. 2. Urinary endothelin-1-like immunoreactivity/creatinine during, 1 week after, and 2 weeks after cis-platinum treatment was significantly higher than before cis-platinum. There was no difference in urinary endothelin-1-like immunoreactivity/creatinine during, 1 week after and 2 weeks after cis-platinum. 3. Among the four parameters, urinary endothelin-1-like immunoreactivity/creatinine showed the highest level after cis-platinum treatment. Urinary β2-microglobulin/creatinine most rapidly returned to normal levels after cis-platinum. 4. Although urinary endothelin-1-like immunoreactivity/creatinine did not show any significant correlations with urinary N-acetyl-β-d-glucosaminidase (r = 0.291, not significant) or urinary microalbumin/creatinine (r = 0.076, not significant), it showed a significant correlation with urinary β2-microglobulin/creatinine (r = 0.475, P & lt; 0.05). 5. These results suggest that endothelin-1 may be a sensitive urinary parameter in detecting cis-platinum-induced renal tubular injury.
Type of Medium:
Online Resource
ISSN:
0143-5221
,
1470-8736
Language:
English
Publisher:
Portland Press Ltd.
Publication Date:
1994
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