In:
Clinical and Experimental Pharmacology and Physiology, Wiley, Vol. 45, No. 12 ( 2018-12), p. 1265-1273
Abstract:
Endothelial cells ( EC s) mainly depend on aerobic glycolysis to generate angiogenesis. Deregulation of glycolysis is often observed in human endothelial cells during angiogenesis. In the present study, we first report that resveratrol ( RST ), which has been intensively studied in glucose metabolism of various cancer cells, has a profound inhibitory effect on tube formation and migration via suppression of glycolysis in human umbilical vein endothelial cells ( HUVEC s) induced by vascular endothelial growth factor ( VEGF ). Moreover, we further reveal that RST reduced the mRNA and protein level of glucose transporter‐1( GLUT 1), hexokinase II ( HK 2), phosphofructokinase‐1( PFK 1) and pyruvate kinase M2 ( PKM 2) through modulation of ERK ‐mediated PKM 2 nuclear translocation. Our results provide a novel mechanism to account for the inhibition of RST on VEGF ‐mediated angiogenesis and suggest that targeting aerobic glycolysis or nuclear PKM 2 may be a new approach for pathological angiogenesis prevention or treatment.
Type of Medium:
Online Resource
ISSN:
0305-1870
,
1440-1681
DOI:
10.1111/cep.2018.45.issue-12
DOI:
10.1111/1440-1681.13017
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
189277-0
detail.hit.zdb_id:
2020033-X
SSG:
15,3
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